Bereta - instructions for use, reviews, analogs and forms of release (10 mg and 20 mg tablets) drugs for the treatment of stomach ulcers, duodenal ulcers and Helicobacter control in adults, children and pregnancy

In this article, you can read the instructions for using the drug Bereta. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Beret in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Beret Analogues in the presence of existing structural analogs. Use to treat stomach ulcers, duodenal ulcers and the fight against Helicobacter in adults, children,as well as during pregnancy and lactation.

Bereta - antiulcer, inhibitor of H-K-ATPase (proton pump). The mechanism of action is associated with inhibition of the enzyme H-K-ATPase in the parietal cells of the stomach, which leads to blocking the final stage of the formation of hydrochloric acid. This action is dose-dependent and leads to inhibition of both basal and stimulated secretion of hydrochloric acid regardless of the nature of the stimulus.

Composition

Rabeprazole sodium + excipients.

Pharmacokinetics

After oral intake absorbed from the digestive tract. Absolute bioavailability is about 52% due to the effect of "first passage" through the liver. Bioavailability of Rabeprazole does not increase with multiple admission. The intake of food and time of reception during the day does not affect the absorption of rabeprazole. Binding to plasma proteins is 97%. Rabeprazole sodium is exposed to the effect of "first passage". Metabolized in the liver with the participation of isoenzymes of the CYP system. The main metabolites (thioester and carboxylic acid) and minor metabolites (sulfone, dimethyl thioester and mercaptopuric acid conjugate) are present in low concentrations.Approximately 90% is excreted in the urine mainly in the form of two metabolites: a conjugate of mercaptopuric acid and a carboxylic acid. In toxicological studies, 2 unidentified metabolites were found in laboratory animals. The rest is excreted with feces. In elderly patients the excretion of rabeprazole is somewhat slowed down.

Indications

• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• peptic ulcer of the stomach and duodenum, associated with Helicobacter pylori (Helicobacter) (in combination with antibiotics);
• gastroesophageal reflux.

Forms of release

Tablets covered with enteric-coated shell 10 mg and 20 mg (sometimes mistakenly called capsules).

Instructions for use and dosing regimen

Is taken internally. Single dose - 10-20 mg. Frequency and duration of use depend on the indications and treatment regimen.

Side effect

• diarrhea, constipation;
• nausea, vomiting;
• stomach ache;
• flatulence;
• dry mouth;
• dyspepsia;
• eructation;
• anorexia;
• gastritis;
• stomatitis;
• increased activity of hepatic transaminases;
• headache;
• asthenia;
• dizziness;
• insomnia;
• nervousness;
• drowsiness;
• depression;
• impaired vision and taste;
• rhinitis;
• pharyngitis;
• cough;
• sinusitis;
• bronchitis;
• skin rash;
• itching;
• back pain;
• influenza-like syndrome;
• myalgia;
• chest pain;
• chills;
• cramps of the calf muscles;
• urinary tract infection;
• arthralgia;
• fever;
• increase in body weight;
• increased sweating;
• leukocytosis.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• increased sensitivity to rabeprazole sodium or substituted benzimidazoles.

Application in pregnancy and lactation

Beret's drug is contraindicated in pregnancy and lactation.

In experimental studies it was found that rabeprazole penetrates insignificantly through the placental barrier, but there were no violations of fertility or fetal development defects; is excreted with the milk of lactating rats.

Use in children

Clinical experience of using rabeprazole in children is not available, therefore, the use is not recommended.

special instructions

Before the beginning of therapy it is necessary to exclude malignant neoplasms of the stomach, tk. The use of rabeprazole can mask symptoms and delay proper diagnosis.

Patients with hepatic or renal dysfunction are not required to adjust the dose, however, in patients with severe impairment of liver function, it is recommended that rabeprazole be used with caution.

When used simultaneously with Beret's drug, dosages of Ketoconazole and Digoxin should be adjusted.

In experimental studies, carcinogenic effects of rabeprazole have not been established, however, in the study of mutagenicity, ambiguous results were obtained. Tests on lymphoma cells in mice were positive, while the micronucleus test and the DNA repair test were negative.

Drug Interactions

With simultaneous use with digoxin, an increase (from small to moderate) of digoxin concentration in the blood plasma is possible.

With simultaneous application with ketoconazole, its bioavailability decreases.

Analogues of Beret's drug

Structural analogs for the active substance:

• Vero-rabeprazole;
• Zolispan;
• Zulbeks;
• Нофлюкс;
• Ontime;
• Parries;
• Rabelock;
• Rabeprazole sodium;
• Hyrabezole.

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