Excedrine - instructions for use, analogs, reviews and release forms (tablets) of the drug for the treatment of neuralgia, migraine and other pain in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Excedrine. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Exsedrine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Excedrine with available structural analogues. Use for the treatment of neuralgia, migraine and other pain in adults, children, as well as during pregnancy and lactation.

Excedrine - combined preparation containing paracetamol, Acetylsalicylic acid and caffeine.

Paracetamol has an analgesic, antipyretic and extremely weak anti-inflammatory effect, which is associated with its influence on the thermoregulatory center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues.

Acetylsalicylic acid (aspirin) has an analgesic, antipyretic and anti-inflammatory effect. Rapidly relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and slows the process of thrombosis, improving microcirculation in the focus of inflammation.

Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation. Reduces drowsiness, fatigue, increases mental and physical performance. In this combination, Caffeine in a small dose has practically no stimulating effect on the central nervous system, but it contributes to the normalization of the vascular tone of the brain and the acceleration of blood flow in it.

Composition

Paracetamol + Acetylsalicylic acid + Caffeine + excipients.

Pharmacokinetics

Paracetamol is easily absorbed in the gastrointestinal tract. Paracetamol is metabolized in the liver and excreted by the kidneys, mainly in the form of glucuronides and sulfate conjugates. Less than 5% of paracetamol is excreted unchanged. The association with plasma proteins is negligible at usual therapeutic doses, however, it increases with increasing dose. Hydroxylated metabolite, formed in small amounts in the liver under the influence of mixed oxidases and usually rendered harmless by binding to glutathione, can accumulate in case of an overdose of paracetamol and cause liver damage.

Acetylsalicylic acid is rapidly and completely absorbed, undergoes rapid hydrolysis in the gastrointestinal tract, liver and blood to the formation of salicylates, which undergo further metabolism, mainly in the liver.

Caffeine is absorbed completely and quickly. The maximum concentrations are observed in the interval from 5 to 90 minutes after administration on an empty stomach. In adults, excretion occurs almost entirely through hepatic metabolism.There is a pronounced variability in the individual values ​​of elimination in adults. Caffeine is distributed in all body fluids. Communication of caffeine with plasma proteins is 35%. Caffeine is almost completely metabolized by oxidation, demethylation and acetylation and excreted by the kidneys.

Indications

Pain syndrome of medium and light intensity of different origin:

• headache;
• migraine;
• toothache;
• neuralgia;
• arthralgia and myalgia (pain in muscles and joints);
• Algodismenorea (pain in menstruation).

Forms of release

The tablets covered with a cover.

Instructions for use and dosing regimen

The drug is taken orally during or after a meal.

Adults and adolescents with 15 years of age: 1 tablet every 4-6 hours.

At the first signs of migraine, 2 tablets are taken.

The average daily dose is 3-4 tablets a day, the maximum daily dose is 6 tablets per day.

After taking 2 tablets, relief of headache and other types of pain usually comes quickly - after 15 minutes, with migraine, relief usually comes after 30 minutes.

With pain syndrome, the drug should not be taken for more than 5 days without consulting a doctor.When migraine, the drug should not be taken more than 3 days without consulting a doctor.

Side effect

• gastralgia;
• nausea, vomiting;
• hepatotoxicity;
• nephrotoxicity;
• erosive ulcerative lesions of the gastrointestinal tract;
• allergic reactions;
• tachycardia;
• increased blood pressure;
• bronchospasm;
• dizziness;
• headache;
• visual impairment;
• noise in ears;
• reduction of platelet aggregation;
• hemorrhagic syndrome (nasal bleeding, gum bleeding, purpura and other symptoms);
• kidney damage with papillary necrosis;
• deafness;
• malignant exudative erythema (Stevens-Johnson syndrome);
• toxic epidermal necrolysis (Lyell's syndrome);
• Reye syndrome (Raynaud) in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver dysfunction).

Contraindications

• hypersensitivity to any of the components in the formulation;
• erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
• gastrointestinal bleeding;
• complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or others.non-steroidal anti-inflammatory drugs (including in history);
• surgical interventions accompanied by bleeding;
• hemophilia;
• hemorrhagic diathesis;
• hypoprothrombinemia;
• severe arterial hypertension;
• portal hypertension;
• severe course of ischemic heart disease;
• glaucoma;
• avitaminosis K;
• kidney failure;
• simultaneous use of other drugs containing paracetamol, acetylsalicylic acid or other non-steroidal anti-inflammatory drug;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• lactation;
• increased excitability;
• sleep disorders;
• Children under 15 years of age (the risk of developing Reye's syndrome in children with hyperthermia in the presence of viral diseases).

Application in pregnancy and lactation

Despite the fact that acetylsalicylic acid can be used in the 2nd trimester of pregnancy, the safety of this combination in pregnant and breast-feeding has not been studied, and the drug is contraindicated in pregnant women (in all trimesters) and breastfeeding.

Use in children

Excedrine is contraindicated in children and adolescents under the age of 15 (the risk of developing Reye's syndrome in children with hyperthermia in the presence of viral diseases).

special instructions

If symptoms persist after taking the drug, worsening or new symptoms occur, immediately consult a doctor.

When taking the drug at the recommended dose, the same amount of caffeine is fed into the body as it is contained in one cup of coffee, so you should reduce the consumption of caffeine-containing products when treated with this drug in order to avoid the development of nervous excitement, irritability, insomnia and rapid heartbeat against caffeine overdose. If you suspect an overdose, you should immediately seek medical help, even if you have no symptoms.

It should be refrained from drinking alcohol while taking the drug Excedrine due to increased risk of liver damage and gastrointestinal bleeding.

Since acetylsalicylic acid slows blood clotting, the patient, who is to undergo surgery, must warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid, so in patients with a predisposition, the drug can trigger a gout attack.

With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary.

Influence on ability to drive vehicles and work with mechanisms

It was not reported on the effect of the drug on the ability to drive and work with machinery.

Drug Interactions

The drug can enhance the action of heparin, indirect coagulants, reserpine, steroid hormones and hypoglycemic) drugs.

Simultaneous use with other non-steroidal anti-inflammatory drugs, Methotrexate increases the risk of side effects. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-gouty drugs that promote the excretion of uric acid. Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other inducers of microsomal liver enzymes contribute to the formation of toxic metabolites of paracetamol that affect liver function. Metoclopramide accelerates the absorption of paracetamol. Under the influence of paracetamol, the half-life of chloramphenicol increases five-fold.With repeated admission, paracetamol can enhance the effect of anticoagulants (coumarin derivatives).

Simultaneous reception of paracetamol, acetylsalicylic acid and alcoholic beverages increases the risk of hepatotoxic effects. Caffeine accelerates the absorption of ergotamine.

Analogues of the drug Excedrine

Structural analogs for the active substance:

• Aquacitramone;
• Ascofen;
• Acifein;
• Co-plus;
• Migrenol Extra;
• Citramarin;
• Citramon;
• Citramon Ultra;
• Citrapar.

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