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Pariet - instructions for use, analogs, reviews and release forms (10 mg and 20 mg tablets) of the drug for the treatment of gastritis and ulcers, including Helicobacter in adults, children and during pregnancy. Composition

Pariet - instructions for use, analogs, reviews and release forms (10 mg and 20 mg tablets) of the drug for the treatment of gastritis and ulcers, including Helicobacter in adults, children and during pregnancy. Composition

In this article, you can read the instructions for using the drug Parries. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Pariet in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Pariet in the presence of existing structural analogues. Use to treat gastritis and ulcers of the stomach and duodenum, including Helicobacter in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Parries - antiulcer drug. Proton pump inhibitor.

 

Rabeprazole sodium (active ingredient Pariet) belongs to the class of antisecretory compounds, which are chemically substituted benzimidazoles. The drug inhibits the activity of the enzyme H-K-ATPase, thus blocking the final stage of the synthesis of hydrochloric acid. This effect is dose-dependent and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. As a weak base, Rabeprazole at any dose is rapidly absorbed and concentrated in the acidic environment of parietal cells.

 

Antisecretory activity. After ingestion Pariet 20 mg antisecretory effect occurs within 1 h and reaching a maximum after 2-4 h. Inhibition of basal and stimulated acid secretion food after 23 hours after the first dose of rabeprazole sodium was 62 and 82%, respectively, and the duration of this the action reached 48 hours. The inhibitory effect of rabeprazole sodium on acid secretion is somewhat enhanced during the daily intake of 1 tablet, stable oppression of secretion is achieved 3 days after the start of the drug.After the end of reception of rabeprazole secretory activity is restored after 2-3 days.

 

The role of Helicobacter pylori in the development of peptic ulcer, including gastric ulcer and duodenal ulcer, is noted. Helicobacter pylori is the main factor in the development of gastritis and ulcers in these patients. The results of recent studies suggest a causal relationship between Helicobacter pylori and gastric carcinoma.

 

It was found that rabeprazole has a bactericidal effect on Helicobacter pylori. Eradication of Helicobacter pylori with Pariet and antimicrobial medications leads to a high degree of healing of mucosal lesions. According to the results of controlled randomized clinical trials, the use of rabeprazole 20 mg twice a day in combination with two antibiotics, for example, Clarithromycin and Amoxicillin or clarithromycin and Metronidazole for 1 week allows to achieve a level of eradication of Helicobacter pylori of more than 80% in patients with gastroduodenal ulcers. As expected, a trend toward low eradication was noted in patients with baseline resistance to metronidazole. When choosing the appropriate combination for the eradication of Helicobacter pylori should be guided by approved standards of treatment.Patients with persistent infection (in the presence of initially sensitive strains of microorganisms) should consider the possibility of developing secondary resistance to antibacterial drugs when choosing a treatment regimen.

 

Other effects. At present, there is no evidence that rabeprazole causes systemic effects from the central nervous system, cardiovascular and respiratory systems. Steaming at the dose of 20 mg per day for 2 weeks did not affect the function of the thyroid gland, the metabolism of carbohydrates, as well as the concentration in the blood of parathyroid hormone, cortisol, estrogen, testosterone, prolactin, cholecystokinin, secretin, glucagon, FSH, LH, renin, aldosterone and STH.

 

Composition

 

Rabeprazole sodium + excipients.

 

Pharmacokinetics

 

Rabeprazole is rapidly absorbed from the intestine. Bioavailability does not change with multiple administration of rabeprazole. The intake of food and the time of taking the drug within a day have no effect on the absorption of rabeprazole. In humans, the binding of rabeprazole to plasma proteins is about 97%. About 90% is excreted in urine mainly in the form of two metabolites: M5 and M6. About 10% is excreted with feces.

 

Indications

  • duodenal ulcer in the phase of exacerbation;
  • stomach ulcer in the phase of exacerbation;
  • gastroesophageal reflux disease (GERD): erosive reflux-esophagitis (treatment), symptomatic treatment of GERD (ie NERB - non-erosive reflux disease);
  • Zollinger-Ellison syndrome or other conditions characterized by pathological hypersecretion.

 

In combination with antibacterial agents:

  • for eradication Helicobacter pylori (Helicobacter pylori) in patients with peptic ulcer or chronic gastritis;
  • for the treatment and prevention of recurrences of ulcers in patients with peptic ulcer associated with Helicobacter pylori.

 

Forms of release

 

Tablets coated with enteric coating 10 mg and 20 mg.

 

Instructions for use and dosing regimen

 

With peptic ulcer and duodenal ulcer in the phase of exacerbation, it is recommended to take 1 tablet (20 mg) once a day in the morning for 4-6 weeks.

 

In some patients with exacerbation of duodenal ulcer, a good effect is the reception once a day 1 tablet of 10 mg.

 

In most patients with duodenal ulcer, ulcer healing occurs within 4 weeks,but some patients may need an additional 4-week course of treatment with Pariet for healing ulcers.

 

In most patients with peptic ulcer disease, healing occurs within 6 weeks, but some patients may need an additional 6-week course of treatment with Pariet for healing ulcers.

 

In the treatment of gastroesophageal reflux disease (GERD), it is recommended to take Pariet 1 tablet (20 mg) once a day for 4-8 weeks.

 

For maintenance therapy GERB Pariet is prescribed in a dose of 10 mg or 20 mg 1 time per day, depending on the response to treatment.

 

For symptomatic treatment of GERD in patients without esophagitis, Pariet is prescribed at a dose of 10 mg once a day for 4 weeks. If after 4 weeks of treatment the symptoms do not disappear, you should conduct an additional examination of the patient.

 

For the treatment of Zollinger-Ellison syndrome and other conditions characterized by pathological hypersecretion, the dose is selected individually. The initial dose is 60 mg per day, then the dose is increased and the drug is prescribed in a dose of up to 100 mg per day for a single dose or 60 mg twice a day.For some patients, fractional dosing of the drug is preferred. Treatment should continue as clinical need arises. In some patients with Zollinger-Ellison syndrome, the duration of treatment with rabeprazole was up to 1 year.

 

For the treatment of duodenal ulcer or chronic gastritis associated with Helicobacter pylori infection, several eradication options using appropriate combinations of antibiotics are used. A course of treatment of 7 days with one of the following combinations of drugs is recommended:

  1. Pariet 20 mg twice a day + clarithromycin 500 mg 2 times a day and amoxicillin 1 g 2 times a day.
  2. Pariet 20 mg twice a day + clarithromycin 500 mg twice a day and metronidazole 400 mg 2 times a day.

 

The best results of eradication, exceeding 90%, are observed when using the combination of the drug Pariet with clarithromycin and amoxicillin.

 

According to the indications, requiring the drug once a day, Pariet should be taken in the morning before meals. It is established that neither the time of day nor the intake of food does not affect the activity of the drug. But the recommended time of taking the Pariet tablets promotes better adherence to the patient's treatment regimen.

 

Tablets should be swallowed whole, without chewing or grinding.

 

Side effect

  • diarrhea;
  • abdominal pain;
  • flatulence;
  • dry mouth;
  • nausea, vomiting;
  • constipation;
  • anorexia;
  • headache;
  • asthenia;
  • insomnia;
  • drowsiness;
  • dizziness;
  • thrombocytopenia, neutropenia, leukopenia;
  • skin rash;
  • swelling of the face;
  • dyspnea;
  • erythema;
  • bullous eruptions (reactions disappear after drug withdrawal);
  • backache;
  • influenza-like syndrome;
  • decreased appetite;
  • increase in body weight;
  • depression;
  • impaired vision or taste;
  • stomatitis;
  • increased sweating.

 

Contraindications

  • pregnancy;
  • lactation (breastfeeding);
  • hypersensitivity to the components of the drug;
  • hypersensitivity to substituted benzimidazoles.

 

Application in pregnancy and lactation

 

Pariet is contraindicated in pregnancy and lactation (breastfeeding).

 

Data on the safety of the drug Pariet during pregnancy is not.

 

In experimental studies of reproductive performance in rats and rabbits, there were no signs of impaired fertility or fetal developmental defects caused by rabeprazole; However, in rats in small quantities, the drug penetrates the placental barrier.

 

It is not known whether rabeprazole is excreted in human breastmilk. Appropriate studies in lactating women were not conducted. At the same time, rabeprazole is found in the milk of lactating rats, therefore, if it is necessary to use the drug during lactation, breastfeeding should be discontinued.

 

Use in children

 

Pariet is not recommended for children, since there is currently no experience of its use in pediatric practice.

 

special instructions

 

Before the beginning of therapy with Pariet, the presence of a malignant neoplasm of the stomach must be excluded. The drug may mask symptoms and delay the correct diagnosis.

 

In a special study in patients with mild or moderate liver function abnormalities, there was no significant difference in the frequency of the adverse effects of Pariet from the selected in the sex and age of healthy individuals, but nevertheless it is advisable to use caution at the first prescription of the drug. It paralyzes patients with severe impaired liver function.

 

Patients with impaired renal or hepatic function correction of the dose of Pariet is not required.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Based on the peculiarities of pharmacodynamics of rabeprazole and its profile of side effects, it is unlikely that Pariet has an effect on the ability to drive vehicles and control mechanisms. However, in case of drowsiness, these activities should be avoided.

 

Drug Interactions

 

Pariet is metabolized by microsomal hepatic isoenzymes of the cytochrome P450 system. Studies have shown that in healthy volunteers, rabeprazole does not enter a clinically significant drug interaction with amoxicillin and other drugs that are metabolized by this enzyme system (warfarin, phenytoin, theophylline, diazepam).

 

Pariet causes a pronounced and prolonged decline in the production of hydrochloric acid. Therefore, with simultaneous use with drugs, the absorption of which depends on the pH of the contents of the stomach, there was a drug interaction.

 

In healthy volunteers, the use of rabeprazole sodium caused a decrease in the concentration of Ketoconazole in the blood plasma by 33% and an increase in the minimum Digoxin concentration by 22%.Therefore, with the simultaneous use of the drug Pariet with ketoconazole or digoxin, it is necessary to adjust the doses of the latter.

 

The concentrations of rabeprazole and the active metabolite of clarithromycin, when used simultaneously, are increased by 24% and 50%, respectively. This increases the effectiveness of this combination in the eradication of Helicobacter pylori.

 

The study found no interaction between the drug Pariet and liquid antacids. In addition, no clinically significant interaction of the drug pariet with food was detected.

 

Analogues of the drug pariet

 

Structural analogs for the active substance:

  • Zolispan;
  • Zulbeks;
  • Ontime;
  • Rabelock;
  • Rabeprazole;
  • Hyrabezole.

 

Analogues for the pharmacological group (proton pump inhibitors):

  • Acrylase;
  • Vero Omeprazole;
  • Gastrozole;
  • Demeprazole;
  • Zhelezolic;
  • A zerocide;
  • Zipantola;
  • Zolispan;
  • Zolser;
  • Zulbeks;
  • Controllers;
  • Chrismel;
  • Crosatide;
  • Lanzabel;
  • Lanzap;
  • Lansoptol;
  • Lansoprazole;
  • Lansofed;
  • Lancid;
  • Losek;
  • Loenzar sanovel;
  • Nexium;
  • Nolpaz;
  • Omez;
  • Omez Insta;
  • Omesol;
  • Omekaps;
  • Omeprazole;
  • Omepros;
  • Omeface;
  • Omizak;
  • OmiPix;
  • Omitox;
  • Ontime;
  • Ortanol;
  • Ozid;
  • Pantaz;
  • Panum;
  • Pepazol;
  • Pepticum;
  • Пиженума сановель;
  • Plem;
  • Pomez;
  • Puloreph;
  • Rabelock;
  • Rabeprazole;
  • Romesque;
  • Sunpras;
  • Ulzol;
  • Ulcozol;
  • Ulter;
  • Ultop;
  • Hirabesol;
  • Helicid;
  • Helol;
  • Cisagast;
  • Esomeprazole;
  • Epicurus.

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Reviews (5):
Guests
Galkina Olga
The drug can and good, but in the last days of the reception there were severe back pain, diarrhea, insomnia. And most importantly the temperature is 37.8. Why do not all instructions contain a complete list of side effects? And I wonder where my temperature is, but there is a problem with this medicine. There is one day left, but I still will not accept it. Yes, he has plenty of side effects, that's the medicine. Before you take anything, you need to study all the instructions on the Internet.
Administrators
admin
Galkina Olga, In defense of Pariet, I want to note that the temperature sometimes rises and without taking the drug, for example during colds, ARVI and other infections.This is called coincidence and occurs quite often, in this case, the abolition of the drug does not immediately lead to a decrease in temperature (which is logical if it is a side effect), but only after the patient recovers from a cold. And yes, individual reactions in the form of fever and heat are sometimes found during the intake of any medications, but very rarely.
Administrators
admin
Site visitor feedback slavagames moved to the required section:
In special clinical studies, it has been shown that the use of rabeprazole for 36 months does not lead to histological changes in enterochromafin-like cells of biopsy specimens of the bottom and antrum of the stomach, does not affect the incidence of atrophic gastritis, intestinal metaplasia, and limits the prevalence of Helicobacter pylori infection.
Guests
Lyudmila
Lyudmila, Moved your question to the drug Rabeprazole, where it is more appropriate.
admin
Guests
Alla
I know the drug for a long time and take it in case of an exacerbation of gastritis with high acidity. There has never been a temperature increase. It is good to drink with amoxiclav.Pain in the back, too, was not, although there is an osteochondrosis. It is better to feel compared to receiving control, nolpazy and nexium. After them, there is always pain in the ileum.

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