Ambene - instructions for use, reviews, analogs and forms of release (injections in syringes and ampoules for injections) drugs for the treatment of arthritis, arthrosis, gout and osteochondrosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ambien. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of medical specialists on the use of Ambene in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ambien in the presence of existing structural analogues. Use for the treatment of arthritis, arthrosis, gout and osteochondrosis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Ambien - Combined drug, the effect of which is due to the properties of the components that make up its composition. Has anti-inflammatory, analgesic and antipyretic effect, causes uricosuric effect.

Dexamethasone - glucocorticoid, has a pronounced anti-inflammatory effect; the index of its relative anti-inflammatory activity is 30 at almost complete absence of mineralocorticoid activity.

Phenylbutazone - a non-steroidal anti-inflammatory drug (NSAID), a derivative of pyrazolone, has an anti-inflammatory, analgesic and antipyretic effect, causes a uricosuric effect.

Sodium salicylamide-o-acetate, has analgesic effect, and also promotes better solubility of the drug.

Cyanocobalamin involved in the synthesis of nucleic acids, activating the exchange of lipids and therefore important in the regeneration of cells and the formation of the myelin layer of nerve fibers, is part of the drug in a sufficiently high dose to enhance the analgesic effect.

Due to the presence of Lidocaine hydrochloride, injections of the drug are virtually painless.

The active substances that make up Amben potentiate the action of each other, which makes it possible to reduce the dose of dexamethasone.

The drug is maintained for a long time (36 months) by separating solutions A and B from each other.

Composition

Dexamethasone + Lidocaine hydrochloride + Sodium salicylamide-o-acetate + Phenylbutazone + auxiliary substances (solution A).

Cyanocobalamin + Lidocaine hydrochloride + excipients (solution B).

Pharmacokinetics

After intramuscular injection, Dexamethasone is rapidly absorbed into the systemic circulation. Phenylbutazone has a high degree of binding to plasma proteins. Dexamethasone and phenylbutazone penetrate the placenta, are excreted in breast milk. Due to the high binding to plasma proteins, the metabolism of phenylbutazone is slow (prolonged action of the drug).

Indications

Short-term treatment of acute conditions with:

• articular syndrome with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout;
• neuritis, neuralgia, radiculitis (including with degenerative diseases of the spine);
• sports injuries.

Forms of release

Solution for intramuscular administration (consists of ready syringes and ampoules of solution A and B for injection).

Other dosage forms, be it pills or ointment, do not exist.

Instructions for use and how to use them

The drug is prescribed for 1 injection daily or every other day. Produce no more than 3 injections per week. If it is necessary to conduct repeated courses of treatment, the interval between them should be at least several weeks. The drug is injected deeply intramuscularly, slowly; the patient should be in a horizontal position.

Rules for the preparation of injection solution

When using Ambene in the form of a set of 2 ampoules, first, a solution of A is added to the syringe, then solution B.

When using the drug in the form of a finished syringe, remove the rubber cap from the conical part of the syringe; the attached sterile needle, having removed the protective element, is placed on the cone; slowly move the piston rod with the plug forward until the first drop of solution appears. With the correct technique for preparing for injection, solution B enters through the connecting bridge into the anterior chamber of the syringe and mixes with solution A.The preparation is administered immediately after mixing the solutions. The temperature of the finished solution should be close to the patient's body temperature.

Side effect

• ulcerogenic effect;
• anorexia;
• gastralgia;
• nausea, vomiting;
• diarrhea;
• bleeding and perforation of the gastrointestinal tract;
• hemorrhagic pancreatitis;
• leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, aplastic anemia;
• exanthema;
• itching;
• fever;
• Stevens-Johnson syndrome;
• Lyell's syndrome;
• lupus-like syndrome;
• bronchospasm;
• dizziness;
• headache;
• sleep disorders;
• excitation;
• a disorder of vision and hearing;
• mental disorders;
• arterial hypotension;
• orthostatic collapse;
• pain in the area of ​​injection;
• the development of abscesses and tissue necrosis;
• the Itenko-Cushing syndrome;
• mycosis;
• impaired renal function;
• manifestation of immunosuppressive action (lowering resistance to infections, slowing healing of wounds);
• lymphadenopathy;
• sialadenitis.

Contraindications

• acute gastritis;
• peptic ulcer of the stomach and duodenum (including in the anamnesis);
• diseases of the cardiovascular system (incl.acute myocardial infarction, chronic heart failure in the phase of decompensation, myocardial diseases with conduction disruption, ventricular arrhythmias);
• severe renal dysfunction;
• severe liver dysfunction;
• severe thyroid dysfunction;
• viral infection (including herpetic infection, chicken pox, parotitis, poliomyelitis, with the exception of bulbar disease);
• systemic mycosis;
• glaucoma;
• myelosuppression;
• pronounced myopathy, myasthenia gravis;
• Sjogren's syndrome;
• systemic lupus erythematosus;
• hemorrhagic diathesis;
• giant-cell (temporal) arteritis, rheumatic polymyalgia;
• pancreatitis;
• stomatitis;
• period 8 weeks before and 2 weeks after routine vaccination;
• lymphadenitis after administration of BCG vaccine;
• surgical operations;
• pregnancy;
• lactation (breastfeeding);
• children's age till 14 years;
• old age;
• information in the history of the occurrence of urticaria, acute rhinitis, bronchospasm on the intake of acetylsalicylic acid or other NSAIDs;
• hypersensitivity to the drug components, derivatives of pyrazolone, salicylates.

Application in pregnancy and lactation

Ambien is contraindicated in pregnancy.

If you need Ambene during lactation, you should decide whether to stop breastfeeding.

Use in children

The drug is contraindicated for children under 14 years.

special instructions

Caution should be given to the drug for renal dysfunction, diabetic patients, patients with tuberculosis, epilepsy, mental illnesses, bronchial asthma, hay fever, chronic nonspecific lung diseases, acute and chronic bacterial infections, amoebiasis, hypertension or hypotension, thromboembolism, marked osteoporosis. In the above cases Ambene is used only with appropriate treatment of the underlying disease or syndrome.

Because of the long half-life of phenylbutazone, prolonged use of Ambene in high doses should take into account the possibility of cumulation of the drug; this is especially true for patients with impaired liver function.

Before the beginning of the Ambien treatment course, a thorough examination of the patient should be carried out, in particular with the aim of excluding peptic ulcer of the stomach and duodenum.

To reduce the risk of side effects, it is necessary to prescribe the drug as little as possible; this is especially true for weakened and elderly patients.

To prevent irritation at the site of intramuscular injection, which is possible with the introduction of highly concentrated solutions of the drug, it is necessary to inject deeply, into different areas. Manipulation is carried out under absolutely sterile conditions.

During the period of drug therapy, the food of the patients should contain a sufficient amount of potassium, protein, Vitamins and low fats, carbohydrates and table salt.

When a fever, headache, changes in the skin and mucous membranes, with the development of leukopenia, agranulocytosis, when staining the stool in a dark color, the drug is canceled.

Phenylbutazone has an impact on the results of studies of thyroid function, therefore, appropriate tests should be conducted no earlier than 2 weeks after the cessation of Ambien treatment.

Drugs containing cyanocobalamin may contribute to the distortion of clinico-laboratory indicators in patients with funicular myelosis and / or pernicious anemia.

Control of laboratory indicators

With prolonged Ambene therapy, systematic monitoring of the pattern of peripheral blood and the function of the kidneys and liver is necessary.

In patients receiving concurrently with Ambien diuretic medicines, regular monitoring of serum potassium levels is necessary.

In patients receiving anticoagulants simultaneously with Ambien, a systematic analysis of the parameters of the blood coagulation system (prothrombin time) should be performed systematically.

Drug Interactions

With the simultaneous use of Ambien and other anti-inflammatory drugs and preparations containing ethanol (alcohol), the risk of bleeding from the gastrointestinal tract increases.

With the simultaneous use of Ambien with oral hypoglycemic agents (sulfonylurea derivatives) or insulin, hyper- or hypoglycemia is possible.

The simultaneous use of Ambien and anticoagulants of indirect action, heparin, Dipyridamole or sulfinpyrazone may require correction of the doses of the drugs in connection with the risk of bleeding.

With simultaneous application from Ambien it is possible to increase the concentrations in the plasma of sulfonamides and lithium preparations.

With the simultaneous use of Ambene and methotrexate, it is possible to increase the toxicity of the latter.

With the simultaneous use of Ambene with phenytoin, the development of symptoms of intoxication is possible.

With the simultaneous use of Ambene with barbiturates, it is possible to intensify their hypnotic activity.

With the simultaneous use of Ambene with cardiac glycosides, it is possible to slow or accelerate the digitalization of patients.

With the simultaneous use of Ambene and antihypertensive drugs, the effect of the latter is reduced.

With the simultaneous use of Ambien and diuretics, a decrease in diuresis and natriuresis, as well as the development of hypo- or hyperkalemia may occur.

With the simultaneous use of Ambien and hormonal contraceptives, the effectiveness of the latter may be reduced.

With simultaneous application of Ambienum with sulfinpyrazone or probenecid, their uricosuric effect may be reduced.

Application before the start of Ambene therapy of drugs - inducers of microsomal liver enzymes (eg, barbiturates, promethazine, rifampicin, hydantoin) reduces the effect of Ambien.

With the simultaneous use of anabolic steroids and methylphenidate enhance the action of Ambien.

Analogues of Ambene

Ambene does not have structural analogs for the active substance.

Analogues on the curative effect (agents for the treatment of arthrosis):

• Actasulide;
• Alflutop;
• Arthra;
• Arthrovit;
• Arthrotheca;
• Aulin;
• Bethanicomylon;
• Brufen;
• Butadione;
• Voltaren Emulgel;
• Glucosamine sulfate;
• Humisol;
• Dexazone;
• Dexamethasone phosphate;
• Diklobene;
• Dicluberl;
• Dicloran;
• Diclofenac;
• Dimexide;
• Diprospan;
• Diphene;
• Don;
• Donalgin;
• Ibuprofen;
• Indomethacin;
• Kalmopyrene;
• Kenalog;
• Coxib;
• Coenzyme compositum;
• Miolastane;
• Movasin;
• Nalfon;
• Naproxen;
• Nikofleks;
• Nimesulide;
• Nifluryl;
• Orthophene;
• Pirabutol;
• Piroxicam;
• Polcortolone;
• Profenide;
• Revmadore;
• Revmon gel;
• Ronidase;
• Rumalon;
• Sanaprox;
• Triamsinolone;
• Fastum gel;
• Feloran;
• Feloran retard;
• Floiled;
• Chondramine;
• Chondrolon;
• Hotemin;
• Cefecon H;
• Cigapan;
• Elderin;
• The Unium.

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