Colchicine - instructions for use, reviews, analogs and formulations (tablets of 0.5 mg and 1 mg) drugs for the treatment of gout, Behcet's disease in adults, children and pregnancy. Composition and action

In this article, you can read the instructions for using the drug Colchicine. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of colchicine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Colchicine in the presence of existing structural analogues. Use for the treatment of gout, Behcet's disease in adults, children, as well as in pregnancy and lactation. Composition and effect of the drug.

Colchicine - a tool that affects the exchange of uric acid. Alkaloid, isolated from corms colchicum Speciosum Stev. Has a pronounced analgesic and anti-inflammatory effect in case of acute gout. Suppresses mitotic activity of granulocytes. Oppresses the formation of leukotriene B4. Reduces migration of leukocytes to the focus of inflammation, inhibits the phagocytosis of microcrystals of uric acid and delays their deposition in tissues.

It has antimitotic action, suppresses (in whole or in part) cellular division in the anaphase and metaphase stage, prevents degranulation of neutrophils. Reducing the formation of amyloid fibrils, prevents the development of amyloidosis.

Composition

Colchicine + excipients.

Pharmacokinetics

After oral administration, it is well absorbed from the digestive tract. It is excreted as metabolites by the kidneys and through the intestine.

Indications

• gout (relief and prevention of seizures);
• gouty arthritis;
• periodic illness (familial Mediterranean fever);
• Behcet's disease;
• chondrocalcinosis;
• scleroderma;
• phlebitis (some forms);
• inflammatory diseases in dentistry and ENT-practice.

Forms of release

Tablets 0.5 mg and 1 mg.

Instructions for use and dosing regimen

Inside. On the first day of treatment - 3 mg per day (1 tablet in the morning and 2 tablets in the evening), on the second and third days - 2 mg per day (1 tablet in the morning and evening), on the 4th and subsequent days - 1 tablet a day (in the evening). For the prevention of acute gouty arthritis - 1 mg per day (evening).

The maximum daily dose is 8 mg.

Side effect

• nausea, vomiting;
• abdominal pain;
• diarrhea;
• impaired renal function;
• leukopenia, agranulocytosis;
• korepobodnaya rash;
• hives;
• alopecia.

Contraindications

• pregnancy;
• severe renal and / or hepatic insufficiency;
• increased sensitivity to colchicine.

Application in pregnancy and lactation

Contraindicated in pregnancy.

Data on the safety of colchicine during lactation are not available.

special instructions

They are used with caution in elderly patients, with diseases of the kidneys, gastrointestinal tract, and heart. When treating colchicine, monitoring of the peripheral blood pattern is necessary.

Drug Interactions

With the simultaneous use of macrolides with antibiotics, the possibility of developing toxic effects of colchicine can not be ruled out, especially in patients with a previous impairment of kidney function.

With simultaneous application with cyanocobalamin it decreases its absorption from the gastrointestinal tract.

Analogues of the drug Colchicine

Structural analogs for the active substance:

• Colchicum Dyspert.

Analogues on the curative effect (remedies for gout):

• Allomaron;
• Allopurinol;
• Allpol;
• Alopron;
• Ambien;
• Apranaks;
• Arthrosylen;
• Arthromax;
• Beliefed;
• Voltaren;
• The dezurik;
• Dexamethasone phosphate;
• Diklobene;
• Dicluberl;
• Diqlovit;
• Diclomelan;
• Diclonac;
• Dicloran;
• Diclofen;
• Diclofenac;
• Diphene;
• Donalgin;
• Ibuprofen;
• Ibusan;
• Ilaris;
• Indowis EU;
• Indomethacin;
• Kalmopyrene;
• Kenalog;
• Ketonal;
• Clynoril;
• Clofezon;
• Lemodus;
• Metindol retard;
• Metindole;
• Nalfon;
• Naprios;
• Naproxen;
• Niflugel;
• Novolide;
• Oxycamox;
• Piroxicam;
• Piroximeter;
• Polcortolone 40;
• Revmavek;
• Revmadore;
• Remetan;
• Remoxicam;
• Reopyrin;
• Sanaprox;
• Sanfinak;
• Sanfipourol;
• Solpaflex;
• Tenikam;
• Tenoktil;
• Tilcotyl;
• Tobitil;
• Triamsinolone;
• Feloran;
• Fleksen;
• Hotemin;
• Celeston;
• Cyston.

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