Folacin - instructions for use, analogs, reviews and release forms (5 mg tablets) for the treatment and prevention of folic acid deficiency in adults, children, pregnancy and planning. Composition of vitamins

In this article, you can read the instructions for using the drug Folacin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Folacin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Folacin in the presence of existing structural analogues. Use for the treatment and prevention of folate deficiency in adults, children, as well as in planning, pregnancy and lactation. The composition of vitamins.

Folacin - a vitamin preparation.Folic acid (the active substance of the preparation Folacin) in the body is converted into tetrahydrofolic acid, as a coenzyme, involved in various metabolic processes, and necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. The drug stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the exchange of choline, histidine. When pregnancy performs a protective function in relation to the action of teratogenic and damaging factors. Promotes normal maturation and functioning of the placenta.

Composition

Folic acid + auxiliary substances.

Pharmacokinetics

After ingestion, folic acid, connecting in the stomach with the internal Factor factor (specific glycoprotein), is well and completely absorbed into the digestive tract. Almost completely binds to plasma proteins. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of Ascorbic acid under the action of the enzyme dihydrofolate reductase).Penetrates through the blood-brain barrier (GEB) and the placenta, excreted in breast milk. It is excreted by the kidneys as if unchanged (if the dose taken is much higher than the daily requirement), and in the form of metabolites. It is excreted by hemodialysis. 5 mg of ingested folic acid is excreted from the body after 5 hours.

Indications

• treatment and prevention of folic acid deficiency in the background of unbalanced or malnutrition;
• treatment and prevention of anemia on the background of a deficiency of folic acid (macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, post-resection anemia, sideroblastic anemia in elderly patients, anemia associated with small bowel disease, sprue and malabsorption syndrome );
• treatment and prevention of anemia in pregnancy and lactation (breastfeeding);
• during pregnancy to prevent the development of neural tube defects in the fetus;
• long-term treatment with folic acid antagonists (methotrexate, sulfamethoxazole / trimethoprim combination), anticonvulsant drugs (phenytoin, primidone, phenobarbital).

Forms of release

Tablets 5 mg.

Instructions for use and dosage

The drug is prescribed inside.

For treatment of megaloblastic anemia, caused by a deficiency of folic acid, appoint 5 mg per day for 4 months, for prophylaxis - 2.5 mg per day.

For the prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel diseases and unbalanced or malnutrition - 15 mg per day, patients with spruce disease - 5-15 mg per day.

To prevent the development of neural tube defects in the fetus - 2.5 mg per day for 4 weeks before the expected pregnancy. Admission is continued for 1 trimester of pregnancy.

Higher maintenance doses may be given to patients with alcoholism, as well as to patients with chronic infections and taking anticonvulsants.

Side effect

• anorexia;
• nausea;
• bloating;
• bitter taste in the mouth;
• skin rashes;
• itching;
• erythema;
• bronchospasm.

Contraindications

• pernicious anemia;
• malignant neoplasms;
• deficiency of cobalamin;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug Folacin is used for indications during pregnancy and lactation (breastfeeding).

Use in children

It is possible to use the drug in children after consulting a specialist and prescribing the necessary dosages of the drug

special instructions

Patients on hemodialysis need elevated amounts of folic acid.

With long-term use of folacin, especially in high doses, it is possible to reduce the concentration in the blood of vitamin B12 (cyanocobalamin).

Long-term use of the drug is recommended to combine with the intake of vitamin B12 (cyanocobalamin).

Use of folic acid (active ingredient of the preparation Folacin) in planning pregnancy, including in men, see extended analytical article.

Drug Interactions

At simultaneous application with chloramphenicol, neomycin, polymyxins, tetracyclines, absorption of folic acid decreases.

With the simultaneous use of folacin reduces the effects of oral contraceptives, ethanol (alcohol), sulfasalazine, cycloserine, glutetimide, methotrexate, phenytoin, primidin, chloramphenicol.

The use of folic acid can reduce the plasma level of phenobarbital, phenytoin or primidon and cause an epileptic fit.

Reduction or change in absorption may occur with the simultaneous use of colestyramine and folic acid, therefore, folic acid should be taken 1 hour before or 4-6 hours after the administration of colestyramine.

Analogues of the drug Folacin

Structural analogs for the active substance:

• 9 months Folic acid;
• Mamifol;
• Folic acid;
• Folic acid forte.

Analogues on the curative effect (means for the treatment of folic deficiency anemia):

• Ascofol;
• Gino Tardiferon;
• Calcium-phosphinate Ebevé;
• Record B12 Sigma Tau;
• Ferro Folgamma;
• Folic acid;
• Calcium folinate;
• Cyanocobalamin.

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