Ortanol - instructions for use, analogs, reviews and release forms (capsules or tablets 10 mg, 20 mg and 40 mg) drugs for the treatment of ulcers, esophagitis and heartburn in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ortanol. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Ortanol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ortanol in the presence of existing structural analogues. Use to treat stomach and duodenal ulcers, esophagitis and heartburn in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Ortanol proton pump inhibitor.Reduces acid production - inhibits the activity of H-K-ATP-ase in parietal cells of the stomach and blocks, thus, the final stage of secretion of hydrochloric acid.

The drug is a prodrug and is activated in the acidic environment of the secretory tubules of parietal cells.

Reduces basal and stimulated secretion irrespective of the nature of the stimulus.

Antisecretory effect occurs within the first hour, a maximum after 2 hours. Inhibition of 50% of maximum secretion lasts 24 hours.

A single dose per day provides fast and effective suppression of day and night gastric secretion, reaching its maximum after 4 days of treatment and disappearing by the end of 3-4 days after the end of the admission.

Composition

Omeprazole + auxiliary substances.

Pharmacokinetics

After taking the drug inside - the absorption is high. Absolute bioavailability is about 30-40%. Binding to blood plasma proteins - 95%. Omeprazole is metabolized in the liver with the formation of 6 pharmacologically inactive metabolites. It is excreted as metabolites by the kidneys (70-77%) and with bile (18-23%).

Indications

• peptic ulcer of the stomach and duodenum (including the prevention of relapses);
• eradication of Helicobacter pylori (Helicobacter pylori) infected patients with gastric ulcer and duodenal ulcer (in combination therapy);
• reflux esophagitis;
• hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis);
• prevention and treatment of lesions of the gastric mucosa and duodenal ulcers due to NSAID (dyspepsia, mucosal erosion, peptic ulcer);
• symptoms of gastroesophageal reflux, such as heartburn, acidic eructation.

Forms of release

Capsules 10 mg, 20 mg and 40 mg (sometimes mistakenly called tablets).

Lyophilizate for the preparation of a solution for infusions (injections in ampoules for injection) 40 mg.

Instructions for use and dosing regimen

Assign inside. Ortanol is taken before meals (usually in the morning before breakfast). The capsule should be swallowed whole, with enough liquid. If the patient can not swallow the capsule Ortanol whole, it is possible to dissolve its contents in a little water or fruit juice (eg, apple or orange).

Peptic ulcer of duodenum: 20 mg once a day for 2 weeks. If after the first course of taking the drug does not complete cicatrization, appoint a second two-week course of therapy. With duodenal ulcer resistant to therapy, the drug is prescribed at a dose of 40 mg once a day, the course of treatment can be extended to 4 weeks.

Stomach ulcer: 20 mg once a day for 4 weeks. If after the first course of taking the drug does not come full cicatrization, then appoint a second four-week course of therapy. With gastric ulcer resistant to therapy, the drug is prescribed in a dose of 40 mg once a day, the course of treatment can be extended to 8 weeks.

Eradication of Helicobacter pylori in combination therapy: Ortanol is prescribed 20 mg twice daily before meals for 2 weeks in combination with antibacterial drugs.

Reflux-esophagitis: 20 mg once a day for 4 weeks. If after the first course of taking the drug does not come a complete cure, a second four-week course of therapy is prescribed. In severe forms of reflux esophagitis treatment course can be extended to 8 weeks.

Hypersecretory conditions: the dose of Ortanol and the duration of treatment of Zollinger-Ellison syndrome are selected individually. The recommended initial dose for adults is 60 mg once a day, the maximum dose is 120 mg per day. When appointing a dose exceeding 80 mg per day, it is divided into several receptions.

When the gastric mucosa and duodenal damage caused by nonsteroidal antiinflammatory drugs (NSAIDs) for the prevention Ortanol administered in a dose of 20 mg daily before breakfast for the entire course of treatment of NSAID; with the purpose of treatment - at a dose of 20 mg per day for 4-8 weeks.

For elderly patients and patients with severe liver disease, the maximum daily dose is 20 mg.

For patients with impaired renal function, dose adjustment is not required.

Side effect

• nausea, vomiting;
• abdominal pain;
• diarrhea or constipation;
• flatulence;
• dry mouth;
• stomatitis;
• hepatitis;
• abnormal liver function;
• the formation of gastric glandular cysts (a consequence of inhibiting the secretion of hydrochloric acid, is benign, reversible);
• headache;
• dizziness;
• a violation of taste sensations;
• drowsiness;
• insomnia;
• excitation;
• depression;
• reversible confusion;
• encephalopathy;
• photosensitization;
• exudative erythema multiforme;
• alopecia;
• increased sweating;
• myalgia;
• arthralgia;
• in some cases, muscle weakness;
• leukopenia, agranulocytosis, thrombocytopenia, pancytopenia;
• hives;
• itching;
• eosinophilia;
• fever;
• angioedema;
• bronchospasm;
• anaphylactoid reactions;
• interstitial nephritis;
• peripheral edema;
• impaired vision;
• gynecomastia.

Contraindications

• childhood;
• lactation period;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The use of Ortanol during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

When taking the drug during lactation, it is necessary to resolve the issue of stopping breastfeeding.

Use in children

Contraindicated in childhood.

special instructions

Before beginning therapy with Ortanol, it is necessary to exclude the presence of malignant process.treatment, masking symptoms, can delay the establishment of the correct diagnosis.

Impact on the ability to drive vehicles and manage mechanisms

There is no evidence of the effect of the drug on the ability to drive vehicles and control mechanisms.

Drug Interactions

With simultaneous application with omeprazole, it is possible to increase T1 / 2 and increase the concentration of warfarin, diazepam, phenytoin, as well as other drugs metabolized in the liver with the participation of the isoenzyme CYP2C19 (lower doses of these drugs may be required).

There may be a violation of absorption of drugs, the bioavailability of which is largely determined by the acidity of the gastric juice (eg, ketoconazole, itraconazole, ampicillin esters, iron salts and cyanocobalamin).

Bioavailability of Digoxin with simultaneous application with Ortanol increases by 10%.

Increases the inhibitory effect on the hemopoietic system of other drugs.

There is no clinically significant interaction with antacids, theophylline, caffeine, quinidine, lidocaine, propranolol, metoprolol, ethanol (alcohol).

Analogues of the medicinal product Ortanol

Structural analogs for the active substance:

• Gastrozole;
• Demeprazole;
• Zhelezolic;
• A zerocide;
• Zolser;
• Chrismel;
• Losek;
• Omez;
• Omeprazole;
• Omizak;
• OmiPix;
• Omitox;
• Ozid;
• Pepticum;
• Pleom 20;
• Pomez;
• Romesque;
• Ulzol;
• Ulcozol;
• Ultop;
• Helicid;
• Helol;
• Cisagast.

Analogues on the curative effect (means for treating heartburn):

• Additive of calcium;
• Aktal;
• Almagel Neo;
• Almol;
• Alfogel;
• Anacid forte;
• Bactistatin;
• Ganaton;
• Gastal;
• Gasterin;
• Gastric;
• Gastricumel;
• Gaviscon;
• Gelusil lacquer;
• Gelusil;
• Gestid;
• Daijin;
• Digestal;
• Domperidone;
• Itomed;
• Maalox;
• Metamol;
• Metovit;
• Motilac;
• Motion;
• Passion;
• Primamet;
• Ranital;
• Ranitidine;
• Rennie;
• Rutatsid;
• Smecta;
• Sukrat;
• Tams;
• Topalcan;
• Cerucal;
• Andrews antacid.

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