Amosin - instructions for use, reviews, analogs and forms of release (tablets and capsules 250 mg and 500 mg, powder for the preparation of 125 mg suspension, 250 mg and 500 mg) antibiotic for treatment of sore throat, cystitis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Amosin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of antibiotic Amosin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Amosin in the presence of existing structural analogs. Use for the treatment of sore throat, pneumonia, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Amosin - an antibiotic of a broad spectrum of action of a group of semisynthetic penicillins. It is bactericidal. Inhibits transpeptidase, breaks the synthesis of peptidoglycan (supporting polymer of the cell wall) in the period of division and growth, causes bacterial lysis. Acid-resistant.

It is active against aerobic gram-positive bacteria: Staphylococcus spp. (staphylococcus) (with the exception of strains producing penicillinase), Streptococcus spp. (streptococcus); aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes (Listeria), Helicobacter pylori (Helicobacter), Klebsiella spp. (Klebsiella).

The microorganisms producing penicillinase are resistant to the action of amoxicillin.

The action develops 15-30 minutes after administration and lasts 8 hours.

Composition

Amoxicillin (in the form of trihydrate) + auxiliary substances.

Pharmacokinetics

After ingestion Amosin quickly and almost completely (93%) is absorbed from the digestive tract. Eating does not affect the absorption of the drug, it does not break down in the acidic environment of the stomach. In high concentrations it is found in plasma, sputum, bronchial secretion (in the purulent bronchial secretion the distribution is weak), pleural and peritoneal fluid, urine,the contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone, adipose tissue, gall bladder (with normal liver function), fetal tissues. When the dose is doubled, the concentration also doubles. Concentration in bile exceeds the concentration in plasma by 2-4 times. In amniotic fluid and vessels of the umbilical cord, the concentration of Amoxicillin is 25-30% of the plasma level in a pregnant woman. Poor penetration of the blood-brain barrier (BBB), with inflammation of the meninges (meningitis) concentration in the cerebrospinal fluid - about 20%. Binding to plasma proteins - 17%. In small amounts excreted in breast milk. Amoxicillin is partially metabolized with the formation of inactive metabolites. Amoxicillin is excreted 50-70% in urine unchanged through tubular excretion (80%) and glomerular filtration (20%), with bile 10-20%.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:

• infections of the respiratory system (including bronchitis, pneumonia);
• infection of the ENT organs (incl.sinusitis, pharyngitis, tonsillitis, acute otitis media);
• infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the digestive tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including erysipelas, impetigo, secondarily infected dermatoses);
• leptospirosis;
• listeriosis;
• Lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmonella;
• meningitis;
• endocarditis (prophylaxis);
• sepsis.

Forms of release

Capsules 250 mg.

Tablets 250 mg and 500 mg.

Powder for the preparation of a suspension for ingestion 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years of age (with a body weight of more than 40 kg) are prescribed 500 mg 3 times a day, in severe cases - 0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, at the age of 2 to 5 years - 125 mg 3 times a day, at the age of 2 years - 20 mg / kg per day in 3 divided doses. The course of treatment is 5-12 days.

For children younger than 5 years, the drug is administered in the form of a suspension (the ideal pediatric form of the drug).

For treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; in the treatment of women, repeated intake of this dose is recommended.

In acute infectious diseases of the digestive tract (paratyphoid, typhoid) and biliary tract, with gynecological infectious diseases adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

With salmonella carrying adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis in small surgical interventions, adults are prescribed a dose of 3-4 g for 1 h before the procedure. If necessary, appoint a second dose after 8-9 hours. In children, the dose is reduced by half.

Rules for the preparation of a suspension from a single dose package

Pour the boiled and cooled water into a clean beaker in the amount indicated in the table, then pour the contents of one packet and mix until a homogeneous suspension is obtained.

• The dose in the package is 125 mg - the required amount of water is 2.5 ml;
• dose in a package of 250 mg - the required amount of water 5 ml;
• dose in the package 500 mg - the required amount of water 10 ml.

After taking the glass, rinse with water, dry and store in a dry, clean place.

Side effect

• hives;
• hyperemia of the skin;
• erythema;
• angioedema;
• rhinitis;
• conjunctivitis;
• fever;
• pain in the joints;
• eosinophilia;
• exfoliative dermatitis;
• exudative erythema multiforme;
• Stevens-Johnson syndrome;
• reactions similar to serum sickness;
• anaphylactic shock;
• dysbiosis;
• change in taste;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomembranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion of consciousness;
• behavior change;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• candidiasis of the vagina;
• superinfection (especially in patients with chronic diseases or reduced resistance of the body).

Contraindications

• allergic diathesis;
• bronchial asthma, pollinosis;
• Infectious mononucleosis;
• lymphocytic leukemia;
• liver failure;
• Gastrointestinal disease in history (especially colitis, associated with the use of antibiotics);
• lactation period (breastfeeding);
• hypersensitivity to the components of the drug;
• increased sensitivity to other penicillins, cephalosporins, carbapenems;
• children under 3 years (for tablets and capsules).

Application in pregnancy and lactation

The use of the drug in pregnancy is possible only in cases where the intended use of therapy for the mother exceeds the potential risk to the fetus.

Application in the period of lactation is contraindicated. If necessary, use during lactation should stop breastfeeding.

Use in children

Contraindicated in children under 3 years (for the form of release in the form of tablets and capsules). Children under the age of 5 years, the drug is administered in the form of a suspension.

special instructions

During the course of treatment with Amosin, it is necessary to monitor the status of the functions of the blood, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.

In the treatment of patients with bacteremia, the bacteriolysis reaction rarely develops (the Yarisch-Gerxheimer reaction).

In patients who are hypersensitive to penicillins, there may be cross-allergic reactions with cephalosporin antibiotics.

In the treatment of mild diarrhea, Amosin should avoid prescribing antidiarrheal drugs that reduce intestinal peristalsis; it is possible to use kaolin- or attapulgite-containing antidiarrhoeic agents. In severe diarrhea it is necessary to conduct differential diagnosis and prescribe appropriate therapy.

Treatment should continue for another 48-72 hours after the disappearance of clinical signs of the disease.

With simultaneous use of estrogen-containing oral contraceptives and amoxicillin, additional methods of contraception should be used, if possible.

Drug Interactions

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group with simultaneous application slow down and reduce the absorption of Amosin; Ascorbic acid - increases its absorption.

Bactericidal antibiotics (incl.aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; bacteriostatic drugs (macrolides, chloramphenicol, lincosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin with simultaneous application increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermenstrual bleeding), as well as drugs, in the process of metabolism of which forms para-aminobenzoic acid.

It is prohibited to share Amosin with alcohol (the hepatotoxic effect of ethanol is increased).

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs (NSAIDs) and drugs that block tubular secretion, while using Amosin to reduce tubular secretion, increase the concentration of amoxicillin.

With the simultaneous use of Amosin and allopurinol, the risk of developing skin rashes increases.

Amoxicillin with simultaneous application reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous application increases the absorption of digoxin.

Analogues of the drug Amosin

Structural analogs for the active substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemox;
• Ospamox;
• Flemoxin Solutab;
• Hiconcile;
• EcoBall.

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