How to properly dilute the antibiotic Ceftriaxone? Which solvents (novocaine, lidocaine, water for injection) should be used to reduce pain and how many are needed to obtain a dosage of 1000 mg, 500 mg and 250 mg for adults and children

In the article we will talk about the cultivation of the antibiotic Ceftriaxone solution of lidocaine 1% and 2%, or water for injection for adults and children, in order to obtain an initial dosage of the finished solution of the preparation 1000 mg, 500 mg or 250 mg. Also we will analyze that it is better to use antibiotics for breeding - Lidocaine, Novocaine or Water for injections and that it helps to remove painful sensations during the injection of the ready-made Ceftriaxone solution.

These questions are most common, so now there will be a reference to this article so that it does not repeat. Everything will be with examples of use.

In all instructions to Ceftriaxone (including drugs with a different name, but with the same composition), it is recommended to use 1% Lidocaine as the solvent.

1% Lidocaine is already contained as a solvent in packages of such drugs as Rosin, Rocefin and others (the active ingredient is Ceftriaxone).

Advantages of Ceftriaxone with a solvent in the package:

• You do not need to buy a solvent separately (to understand which one);
• in the ampoule of the solvent, the necessary dose of the solvent has already been measured, which helps to avoid mistakes when typing the correct amount into the syringe (it is not necessary to understand how much the solvent is taken);
• in the ampoule with the solvent there is already a ready solution of 1% lidocaine - you do not need to cultivate 2% lidocaine up to 1% (in pharmacies it can be difficult to find exactly 1%, it is necessary to dilute additionally with water for injections).

Disadvantages of Ceftriaxone with a solvent in the package:

• antibiotic together with the solvent is more expensive for the price (choose what is more important - convenience or cost).

How to plant and how to prick Ceftriaxone

For intramuscular injection, 500 mg (0.5 g) of the drug should be dissolved in 2 ml (1 ampoule) of 1% solution of lidocaine (or 1000 mg (1 g) of the drug - 3.5 ml of lidocaine solution (usually 4 ml,as it is 2 ampoules of lidocaine in 2 ml)). It is not recommended to inject more than 1 g of solution into one gluteus muscle.

The dosage of 250 mg (0.25 g) is diluted as well as 500 mg (250 mg ampoule did not exist at the time of this writing). That is, 500 mg (0.5 g) of the drug should be dissolved in 2 ml (1 ampoule) of a 1% solution of lidocaine, and then collect in two different syringes for half the finished solution.

Thus, we generalize:

1. 250 mg (0.25 g) of the finished solution is obtained as follows:

500 mg (0.5 g) of the drug should be dissolved in 2 ml (1 ampoule) of a 1% solution of lidocaine and dial the resulting solution into two different syringes (half the finished solution).

2. 500 mg (0.5 g) of the prepared solution is obtained as follows:

500 mg (0.5 g) of the drug should be dissolved in 2 ml (1 ampoule) of a 1% solution of lidocaine and dial the resulting solution into 1 syringe.

3. 1000 mg (1 g) of the finished solution is obtained as follows:

1000 mg (1 g) of the drug should be dissolved in 4 ml (2 ampoules) of a 1% solution of lidocaine and dial the resulting solution into 1 syringe.

How to dilute Ceftriaxone with 2% lidocaine solution

Below the plate with the dilutions of the antibiotic Ceftriaxone 2% solution of lidocaine (2% solution is found in the pharmacy more often than 1% solution of the dilution method which we have already talked about above):

Abbreviations in the table: CEF - Ceftriaxone, P-l-solvent, B-injection for injection.The following are examples and explanations.

Example

The child is given a course of injections of Ceftriaxone twice a day for 500 mg (0.5 g) for 5 days. How many flasks of ceftriaxone, ampoules with a solvent and syringes for the entire course of treatment?

If in the pharmacy you bought Ceftriaxone 500 mg (0.5 g) (the most convenient option) and Lidocaine 2%, you will need:

• 10 vials of ceftriaxone;
• 10 ampoules of lidocaine 2%;
• 10 ampoules of water for injection;
• 20 syringes for 2 ml (2 syringes for each injection - one is applied with a solvent, the second is typed and injected).

If in the pharmacy you bought Ceftriaxone 1000 mg (1.0 g) (did not find ceftriaxone 0.5 g), and Lidocaine 2%, you will need:

• 5 flavors of Ceftriaxone;
• 5 ampoules of lidocaine 2%
• 5 ampoules of water for injection
• 5 syringes for 5 ml and 10 syringes for 2 ml (3 syringes for preparation of 2 injections - one is used for the solvent, the second and third we collect the required volume, the second one immediately, the third is put in the refrigerator and the rings after 12 hours).

The method is acceptable provided that the solution is prepared immediately for 2 injections and the syringe is stored with the solution in the refrigerator (freshly prepared ceftriaxone solutions are physically and chemically stable for 6 hours at room temperature and for 24 hours when stored in a refrigerator at a temperature of 2 ° to 8 ° C ).

Disadvantages of the method: the injection of the antibiotic after storage in the refrigerator may be more painful, while storing the solution may change the color, which indicates its instability.

The same dosage of Ceftriaxone 1000 mg and Lidocaine 2%, although the scheme is more expensive, but less painful and safer:

• 10 vials of ceftriaxone;
• 10 ampoules of lidocaine 2%;
• 10 ampoules of water for injection;
• 10 syringes for 5 ml and 10 syringes for 2 ml (2 syringes for each injection - one (5 ml) we add the solvent, the second (2 ml) is typed and injected). A half of the resulting solution is drawn into the syringe, the rest is discarded.

Disadvantage: treatment is more expensive, but freshly prepared solutions are more effective and less painful.

Now popular questions and answers to them.

Why use Lidocaine, Novocaine for breeding ceftriaxone and why can not water be used for injections?

To dilute Ceftriaxone to the desired concentrations, you can use water for injections, there are no restrictions, but you need to understand that the intramuscular injections of the antibiotic are very painful and if it is done on water (as usually happens in hospitals), then it will hurt as if injected drug, and some time after.So it is preferable to use an anesthetic solution as a dilution agent, and water for injection should be used only as an auxiliary solution when diluted with lidocaine 2%.

There is still such a moment that it is not possible to use lidocaine and Novocaine because of the development of allergic reactions to these solutions. Then the option with the use of water for injection for breeding remains the only possible one. There will already have to endure the pain, since there is a real likelihood of dying from anaphylactic shock, Edema of Quincke or get the strongest allergic reaction (same hives).

Also, lidocaine can not be used for intravenous administration of an antibiotic, only STRICTLY intramuscularly. For intravenous use, it is necessary to dilute the antibiotic in water for injection.

What is better to use Novocain or Lidocaine for breeding an antibiotic?

To dilute Ceftriaxone, do not use Novocaine. This is due to the fact that Novocaine reduces the activity of the antibiotic and in addition increases the risk of developing a mortally dangerous complication in the patient - anaphylactic shock.

In addition, according to the observations of the patients themselves, the following can be noted:

• pain with the introduction of Ceftriaxone is better removed by Lidocaine than Novocain;
• pain associated with administration may be increased after the administration of non-freshly prepared solutions of ceftriaxone with Novocain (according to the instructions to the preparation, the prepared Ceftriaxone solution is stable for 6 hours - some patients practice the preparation of several doses of Ceftriaxone + Novocain solution to save antibiotic and solvent (eg 250 mg ceftriaxone solutions from a powder of 500 mg), otherwise the remainder would have to be discarded, and for the next injection, use a solution or powder from new ampoules).

Is it possible to mix different antibiotics in one syringe, including with Ceftriaxone?

In no case should you mix ceftriaxone solution with solutions of other antibiotics, because it may crystallize or increase the risk of developing allergic reactions in the patient.

How to reduce pain when you administer ceftriaxone?

Logically from the above - you need to dilute the drug on Lidocaine. In addition, not the least role plays and the skill of introducing the finished product (you need to enter slowly, then the pain will be small).

Can I prescribe an antibiotic myself without consulting a doctor?

If guided by the main principle of medicine - Do no harm, then the answer is obvious - NO!

Antibiotics are medicines that can not be dosed and prescribed by yourself, without consulting a specialist. Since choosing an antibiotic on the advice of friends or on the Internet, we thereby narrow the field of activity for doctors who can treat the consequences or complications of your disease. That is, the antibiotic did not work (it was improperly pricked or diluted, incorrectly taken), but it was good, and since the bacteria are already accustomed to it as a result of an incorrect treatment regimen, it will be necessary to prescribe a more expensive reserve antibiotic, which, after the wrong previous treatment, is also unknown whether. So the situation is unequivocal - you need to go to the doctor for prescription and prescription.

Also, allergy sufferers (ideally, again, all patients who are taking this medication for the first time) also showed the appointment of scarification tests to determine the allergic reaction to prescribed antibiotics.

Ideally, it is necessary to sow biological fluids and human tissues with the sensitivity of the sown bacteria to antibiotics so that the purpose of this or that medicine is justified.

I would like to believe that after the appearance of this article in Directory questions on the method and schemes of breeding antibiotic Ceftriaxone will be less, since the main points and schemes I've just sorted out left only to carefully read.