Terialzhen - instructions for use, analogs, testimonials and release forms (5 mg and 10 mg tablets) of a neuroleptic drug for the treatment of neuroses and sleep disorders in adults, children and pregnancy. Composition and interaction with alcohol

In this article, you can read the instructions for using the drug Theeralgen. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of neuroleptic Terialgen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Terialden with available structural analogues.Use for the treatment of neuroses and sleep disorders in adults, children, as well as in pregnancy and lactation. Composition and interaction of the drug with alcohol.

Theeralgen - antipsychotic drug (antipsychotic). Has antihistaminic, spasmolytic, serotonin blocking, moderate alpha-adrenoblocking, antiemetic, hypnotic, sedative and antitussive.

The antipsychotic effect is due to the blockade of the dopamine D2 receptors of the mesolimbic and mesocortical system. Has a low antipsychotic activity, therefore, in acute psychotic conditions is ineffective.

Sedative action is due to blockade of adrenoreceptors of the reticular formation of the brain stem.

Antiemetic effect is due to blockade of dopamine D2 receptors in the trigger zone of the vomiting center.

Hypothermic action is due to blockade of dopamine receptors of the hypothalamus.

Due to its good tolerability it is used in children's, adolescent and gerontological practice.

Composition

Alimemazine tartrate + auxiliary substances.

Pharmacokinetics

When ingested quickly and completely absorbed from the digestive tract. Binding to plasma proteins is 20-30%. A metabolite - sulfoxide is formed. It is excreted as a metabolite with urine (70-80%) for 48 hours.

Indications

• neuroses and neurosis-like conditions of endogenous and organic genesis with predominance of the senestopathic, hypochondriacal, phobic and psycho vegetative disorders;
• psychopathy with asthenic and psychoasthenic disorders;
• anxiety-depressive states in the framework of borderline endogenous and vascular diseases;
• senestropical depression;
• somatized mental disorders;
• state of anxiety and anxiety in somatic diseases;
• sleep disorders of different genesis;
• allergic reactions (symptomatic treatment).

Forms of release

Tablets coated with 5 mg and 10 mg.

Instructions for use and dosage

The drug should be taken orally, distributing the daily dose for 3-4 doses.

The beginning of the drug - in 15-20 minutes, the duration of the action - 6-8 hours.

Adults to achieve a hypnotic effect of 5-10 mg per day; to achieve an anxiolytic effect of 60-80 mg per day.At psychotic conditions - 200-400 mg a day.

Children from 7 years (depending on age and body weight) to achieve a hypnotic effect of 2.5-5 mg per day; as a symptomatic treatment of allergic reactions of 5-20 mg per day; to achieve an anxiolytic effect of 20-40 mg per day; in psychotic states, an increase in the daily dose of the drug to 60 mg per day is possible.

Side effect

• drowsiness;
• lethargy;
• fast fatiguability;
• a paradoxical reaction (anxiety, agitation, nightmarish dreams, irritability);
• confusion of consciousness;
• extrapyramidal disorders (hypokinesia, akathisia, tremor);
• increased nighttime apnea;
• increased convulsive activity (in children);
• blurred vision (paresis of accommodation);
• noise or ringing in the ears;
• dizziness;
• a decrease in blood pressure;
• tachycardia;
• dry mouth;
• atony of the digestive tract;
• constipation;
• decreased appetite;
• dryness in the nose, pharynx;
• increased viscosity of bronchial secretions;
• atony of the bladder;
• retention of urine;
• allergic reactions;
• oppression of bone marrow hematopoiesis;
• increased sweating;
• muscular relaxation;
• photosensitization.

Contraindications

• angle-closure glaucoma;
• hyperplasia of the prostate;
• severe liver disease;
• severe kidney disease;
• Parkinsonism;
• myasthenia gravis;
• Reye's syndrome (Reynaud);
• simultaneous use of MAO inhibitors;
• pregnancy;
• the period of breastfeeding;
• children's age till 7 years;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Contraindicated use of the drug during pregnancy and during breastfeeding.

Use in children

It is possible to use the drug from age 7 at age dosages.

special instructions

With long-term treatment should be systematically to conduct a general blood test, evaluate liver function.

Terialzhen can mask the ototoxic effect (tinnitus, dizziness) of the drugs used together.

Caution should be applied to the drug in chronic alcoholism, if there is a history of complications with phenothiazine drugs, with obstruction of the bladder neck, predisposition to urinary retention, epilepsy, open-angle glaucoma, jaundice, bone marrow depression, arterial hypotension.

To prevent distortion of the results of skin scarification tests for allergens, the drug should be discontinued 72 hours before allergy testing.

During the treatment period, false positive results of a pregnancy test are possible.

During the treatment should not drink alcohol.

Impact on the ability to drive vehicles and manage mechanisms

Against the background of drug treatment should not engage in activities that require increased concentration.

Drug Interactions

Terialzhen increases the effect of opioid analgesics, hypnotics, anxiolytic (tranquilizers) and antipsychotic (antipsychotics) drugs, as well as medicines for general anesthesia, m-holinoblokatorov and antihypertensive drugs. Alimamazine dose should be adjusted with simultaneous use with the above medicines.

With the simultaneous use of alimamazine with derivatives of amphetamine, m-cholinomimetics, ephedrine, guanethidine, levodopa, dopamine, the effect of the latter is weakened.

With the simultaneous use of alimamazine with ethanol (alcohol) and drugs that suppress the central nervous system, CNS depression is observed.

With the simultaneous application of Terialgen with antiepileptic drugs and barbiturates, the threshold of convulsive readiness decreases (a dose adjustment is required).

With the simultaneous use of alimamazine with beta-adrenoblockers, the concentration of the latter in the plasma increases (possibly a marked decrease in blood pressure, arrhythmias).

With the simultaneous use of alimamazine with bromocriptine, the effect of the latter weakens and the concentration of prolactin in the blood serum increases.

With the simultaneous use of alimamazine with tricyclic antidepressants and anticholinergic drugs, the m-cholinoblocking activity of alimamazine increases.

With the simultaneous use of terialogen with MAO inhibitors and phenothiazine derivatives, the risk of arterial hypertension and extrapyramidal disorders increases (simultaneous use is not recommended).

With the simultaneous use of alimamazine with drugs that inhibit bone marrow hematopoiesis, the risk of myelosuppression increases.

With the simultaneous use of alimamazine with hepatotoxic drugs, manifestations of hepatotoxicity of the drug are intensified.

Analogues of Teralzhen

Structural analogs for the active substance:

• Alimemazine Tartrate.

Analogues for the pharmacological group (antipsychotics):

• Abilifay;
• Azaleptin;
• Aminazine;
• Aripiprazole;
• Betamax;
• Victor;
• Haloper;
• Haloperidol;
• Droperidol;
• Zeldox;
• Zilaxera;
• Ziprex;
• Quetiapine;
• Ketiap;
• Ketilept;
• Clozapine;
• Klozasten;
• Clopixol;
• Leponex;
• Leptinorm;
• Limipranil;
• Mazeptil;
• Moditen;
• Nantarid;
• Normiton;
• Olanex;
• Olanzapine;
• Parnasan;
• Prolinate;
• Propazine;
• Prosulfin;
• It is resilient;
• Ridonex;
• Rilept;
• Rispen;
• Risperidone;
• Rispolept;
• Senorm;
• The servicer;
• The Serdolect;
• Seroquel;
• Solian;
• Sonapaks;
• Speridan;
• Sulpiride;
• Tiapride;
• Tizerzin;
• Thiodasin;
• Thioridazine;
• Tyson;
• Torendo;
• Trasin;
• Triftazine;
• Truksal;
• Fluanexol;
• Chlorpromazine;
• Chloroproticsen;
• Eglek;
• Eglonyl;
• Etaperazine.

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