Differin - instructions for use, analogs, reviews and release forms (gel, cream or ointment 0.1%) of the drug for the treatment of acne on the skin in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Differin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Differin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Differin in the presence of existing structural analogs. Use to treat acne on the skin in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Differin - represents a new generation of synthetic retinoids and is a derivative of naphthoic acid. Adapalene (the active substance of the drug Differin) has sebostatic, comedonolytic / anticomedogenic and anti-inflammatory effects.

The drug acts on follicular hyperkeratosis, regulating the process of keratinization and desquamation - has pronounced comedonolytic activity (affects open and closed comedones) and anticomedogenic action (prevents the formation of micro-medones).

The main mechanism of action is the selective binding of the epidermal cells to the nuclear RAGMA receptors, in contrast to the indiscriminate binding of retinoids of previous generations. This mechanism regulates the final differentiation of keratinocytes, which ensures the normalization of the keratinization process and the reduction of the prerequisites for the formation of microcosmodes.

Proved a pronounced anti-inflammatory effect of Differin: inhibition of lipoxygenase, arychidonic acid, cytokines. Has a high anti-inflammatory activity, comparable in strength to Betamethasone and indomethacin, by affecting the factors of inflammation.

Adapalene does not have a photosensitizing effect.

Composition

Adapalene + auxiliary substances.

Pharmacokinetics

Due to low systemic absorption data on the pharmacokinetics of the drug Differin are absent; systemic action is not revealed.

Indications

• acne (pimples).

Forms of release

Gel 0.1%.

Cream 0.1% (sometimes mistakenly called ointment).

Instructions for use and how to use them

Cream or gel evenly, without rubbing, apply to affected areas of the skin 1 time per day before bedtime. The drug should be applied to clean, dry skin.

The therapeutic effect develops after 4-8 weeks of therapy, persistent improvement - after 3 months from the beginning of therapy.

It is possible to conduct repeated courses of therapy with the drug on the recommendation of a doctor.

Differin cream is recommended for sensitive and dry skin.

Differin is indicated for the treatment of acne (acne) of mild and moderate severity as monotherapy, and in acne of moderate severity, also in combination with other local (antibiotics, benzoyl peroxide) and systemic (antibiotics, anti-androgen for oral administration) drugs.

Side effect

• when applying cream or gel in excessive amounts, local reactions are possible in the form of redness andpeeling skin.

Contraindications

• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Differin is not recommended for use during pregnancy and lactation (breastfeeding).

special instructions

When using the drug, avoid contact with eyes and lips.

In some cases, the use of the drug may short-term skin irritation, in such cases, therapy can be interrupted until the symptoms of irritation disappear.

During the period of application of the drug, active sun exposure and UV irradiation should be avoided due to possible slight skin irritation.

During the use of the drug, cosmetic products with a drying or irritating effect (including perfumes, ethanol containing agents) are not recommended.

It is possible to use other means to treat acne on the background of the use of Differin; while Differin is used once a day in the evening before going to bed, and in the morning other means are used (for example, 4% Erythromycin lotion, 1% Clindamycin lotion, benzoyl peroxide on a water basis in a concentration not exceeding 10%).Possible simultaneous use of funds for make-up and moisturizers, not conducive to the formation of comedones.

Drug Interactions

There is no clinically significant interaction of the Differin preparation with simultaneous application of clindamycin phosphate or benzoyl peroxide.

Analogues of the drug Differin

Structural analogs for the active substance:

• Adaclin;
• Adapalen;
• Adolen;
• Clenzite.

Analogues on the therapeutic effect (means for treating acne):

• Acnekutan;
• Androkur;
• Arthromax;
• Basiron AC;
• Balian;
• Bassado;
• Bellune 35;
• Betula Charm;
• Betusil;
• Biseptol;
• Wilprafen;
• Wilprafen solute;
• Delex Acne gel from acne;
• Deleks Acne cleansing lotion;
• Desquam;
• Jess;
• Jess Plus;
• Diane 35;
• Dimephosphone;
• Doxal;
• Doxycycline;
• Dr. Theiss Acne Cream for acne;
• Dr. Theiss Acne Acne Lotion;
• Yeast beer;
• Mirror;
• Zinerit;
• Curious;
• Kutis compositum;
• Purge of Puree;
• Metronidazole;
• Microfolline;
• Monoclin;
• Piolizin;
• Proderm;
• Roaccutane;
• Rosamet;
• Roxithromycin Lek;
• Skinoren;
• Streptonitol;
• Sudokrem;
• Chloe;
• Cytale;
• Edas;
• Eplan;
• Unidox Solutab;
• Yarina Plus.

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