Dona - instructions for use, reviews, analogs and forms of release (powder and solution for intramuscular injection in ampoules) for the treatment of arthrosis and periarthritis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Don. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Dona in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of the Don in the presence of existing structural analogs. Use for the treatment of arthrosis, periarthritis and other diseases of the musculoskeletal system in adults, children, as well as during pregnancy and lactation.

Don - a drug that affects the metabolism in cartilaginous tissue.

Glucosamine sulfate is a salt of a natural ammonomonosaccharide of glucosamine, physiologically present in the human body, with a low molecular weight, carefully purified from macromolecular components. Dona replenishes the endogenous deficiency of glucosamine, stimulates the synthesis of proteoglycans and hyaluronic acid synovial fluid. Increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Promotes the fixation of sulfur during the synthesis of chondroitinsulfuric acid, facilitates the normal deposition of calcium in bone tissue. It inhibits the development of degenerative processes in the joints, restores their function, reducing joint pain. Sulfates also participate in the synthesis of glycosaminoglycans and the metabolism of cartilage tissue. Sulphate esters of side chains in proteoglycans are of great importance for maintaining the elasticity and ability to retain the water of the cartilage matrix.

Reduction of clinical symptoms is usually manifested after 2 weeks from the beginning of treatment with preservation of clinical improvement within 8 weeks after discontinuation of the drug.

Pharmacokinetics

After ingestion of Glucosamine sulfate is rapidly and completely absorbed in the small intestine, the absorption is 90%.

Indications

• osteoarthrosis of various localization (including arthrosis of the knee and hip joints, intervertebral osteochondrosis, spondylarthrosis);
• chondromalacia of the patella;
• shoulder and shoulder periarthritis.

Forms of release

Powder for solution for oral administration 1.5 g.

Solution for intramuscular injection of 400 mg (injections in ampoules).

Tablets coated with 750 mg.

Instructions for use and dosage

Powder

Inside appoint one packet (1.5 g) 1 time per day for 6 weeks. Before use, the contents of the sachet are dissolved in 200 ml of water and taken 20 minutes before meals. The course of treatment can be repeated at intervals of 2 months.

Ampoules

Intramuscularly inject 1 ampoule (400 mg) 3 times a week for 4-6 weeks. Before use, the contents of 1 ampoule (2 ml) should be diluted with the applied solvent (1 ml) in one syringe or mix solution B (solvent) with solution A (solution of the drug) in one syringe. The prepared solution of the drug is administered intramuscularly by 3 ml (solutions A + B) 3 times a week for 4-6 weeks.Injection of the drug can be combined with taking the drug inside the powder to prepare a solution for oral administration (sachets).

Pills

Inside. For 1 tablet 750 mg is taken orally 2 times a day, preferably during a meal, with a glass of water. The symptomatic effect occurs 2-3 weeks after the application of the drug. The minimum course of therapy is 4-6 weeks.

Duration and treatment scheme is appointed by the attending physician.

Side effect

• flatulence, diarrhea, constipation;
• urticaria, itching;
• nausea, vomiting;
• drowsiness;
• headache, dizziness;
• numbness of the tongue and mucous membrane of the oral cavity;
• tremor;
• euphoria;
• disorientation.

Contraindications

• hypersensitivity to glucosamine sulfate and other components of the drug;
• the powder for ingestion contains aspartame and is therefore contraindicated in phenylketonuria;
• solution for the / m administration contains lidocaine and is therefore contraindicated in patients with severe conduction disorders of the heart and acute heart failure, with a history of epileptiform cramps, children under 12 years of age, during pregnancy and lactation, with increased sensitivity to lidocaine.

Application in pregnancy and lactation

Adequate and strictly controlled studies on the safety of the use of the drug Don during pregnancy and lactation were not conducted.

special instructions

Caution should be used in the form of a solution for injection in patients with chronic heart failure, arterial hypotension.

With caution appoint an injection solution simultaneously with beta-adrenoblockers, digitoxin, aymalin, amiodarone, verapamil, quinidine, novocainamide, hexenal, sodium thiopental, MAO inhibitors, polymyxin B, hypnotics or sedatives, cimetidine.

Use in children

Adequate and strictly controlled studies on the safety and efficacy of the drug Don in children under the age of 12 years have not been conducted.

Drug Interactions

The drug is compatible with non-steroidal anti-inflammatory drugs and glucocorticosteroids.

Analogues of the drug Don

Structural analogs for the active substance:

• Aminoarthrin;
• Glucosamine;
• Glucosamine sulfate;
• Glucosamine hydrochloride;
• Sustilac;
• Pharmaskin TGC;
• Chondroxide Maximum;
• Elbon;
• The Unium.

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