Monatinum - instructions for use, analogs, reviews and release forms (tablets 10 mg, 5 mg syrup in 5 ml) of the drug for the treatment of nausea, vomiting and hiccups in diseases of the stomach and intestines in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drugMotinorm. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Motinorm in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Motinorm with available structural analogues.Use for the treatment of nausea, vomiting and hiccups in diseases of the stomach and intestines in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Motinorm antiemetic. Has antiemetic effect, soothes hiccups and eliminates nausea in some cases. The action of Motinorm is due to blockade of central dopamine receptors. This eliminates the inhibitory effect of dopamine on the motor function of the gastrointestinal tract (GIT) and increases the evacuation and motor activity of the stomach.

Composition

Domperidone + auxiliary substances.

Pharmacokinetics

Absorption of Motinorma after intake on an empty stomach is fast. Taking the drug after meals, reduced acidity of gastric juice slow down and reduce absorption. The maximum concentration of the drug in the blood is reached after 1 hour. Bioavailability is 15% (the effect of "first passage" through the liver). Binding to plasma proteins - 90%. It penetrates into various tissues, it does not pass well through the blood-brain barrier (GEB). Metabolised in the liver and in the wall. It is excreted through the intestine (66%) and kidneys (33%), including unchanged - 10% and 1%, respectively.

Indications

• nausea, vomiting, hiccough of different genesis, for example, in toxemia, radiation therapy, diet disorders, taking certain medications (morphine), endoscopic and radiopaque studies, in the postoperative period;
• postoperative hypotension and atony of the stomach and intestines;
• biliary dyskinesia;
• flatulence and related conditions (including bloating, eructation);
• reflux esophagitis;
• gastroesophageal reflux disease (GERD), gastroesophageal reflux;
• cholecystitis acute and chronic;
• cholangitis;
• various types of dyspepsia;
• nausea and vomiting caused by dopaminomimetics.

Forms of release

Tablets 10 mg.

Syrup 5 mg in 5 ml.

Other dosage forms, be it drops or suspension, at the time of publication of the drug in the Directory did not exist.

Instructions for use and dosing regimen

Adults and children older than 5 years - 10 mg 3 times a day for 15-30 minutes before meals, and if necessary 10 mg additional before bed. In acute cases of nausea and vomiting, marked dyspepsia - 20 mg 3-4 times a day. With renal failure, the frequency of application should be reduced.

Side effect

• increased excitability and / or extrapyramidal disorders;
• headache;
• spasms of smooth muscles of the gastrointestinal tract;
• dry mouth, thirst;
• itching, rash, hives;
• increased prolactin levels in plasma;
• galactorrhea (pathological spontaneous discharge of milk from the mammary glands outside of the connection with the process of feeding the baby);
• gynecomastia (enlargement of the breast with hypertrophy of glands and adipose tissue).

Contraindications

• gastrointestinal bleeding;
• mechanical intestinal obstruction;
• perforation of the stomach or intestines;
• prolactinoma (a hormonally active tumor of the anterior lobe of the pituitary gland, producing an excessive amount of the hormone prolactin);
• children under 1 year;
• increased sensitivity to domperidone;
• pregnancy and lactation (breastfeeding).

Application in pregnancy and lactation

Motinorm is contraindicated in pregnancy and lactation.

Use in children

Motinorm is contraindicated in childhood up to 1 year and in syrup, and in tablets. Children under the age of 5 years and children with a body weight of up to 20 kg can be given only syrup, tablets are contraindicated.

special instructions

Caution should be applied to the monothorm for violations of the liver and kidneys.

Drug Interactions

With simultaneous application of Motinorm with antacids, antisecretory drugs (including cimetidine, sodium bicarbonate), the bioavailability of Domperidone decreases.

With simultaneous use with anticholinergic drugs, the action of domperidone is inhibited.

Since the monotinum is metabolized mainly with the participation of the CYP3A4 isoenzyme, it is believed that with the simultaneous use of domperidone and inhibitors of this isoenzyme, including antifungal agents of the azole group, antibiotics of the macrolide group, protease inhibitors of the human immunodeficiency virus (HIV protease), nefazodone, in the blood plasma.

Analogues of the drug Monatinum

Structural analogs for the active substance:

• Domet;
• Domperidone;
• Domstal;
• Motigect;
• Motilac;
• Motilium;
• Motogastrik;
• Motion;
• The passenger.

Analogues of the drug Monatinum on the pharmacological group (antiemetics):

• Avioplant;
• Avomit;
• Bimaral;
• Bonin;
• Validol;
• Granisetron;
• Domegan;
• Domet;
• Domperidone;
• Domstal;
• Zofran;
• Kinedryl;
• Citril;
• Kormenthal;
• Lazaran;
• Latran;
• Levomenthol;
• Metamol;
• Metoclopramide;
• Motigect;
• Motilac;
• Motilium;
• Motogastrik;
• Motion;
• Mint tablets;
• Peppermint leaves;
• Navoban;
• Notirol;
• Ondwell;
• Ondansetron;
• Ondantor;
• Onitsit;
• Sturgeon;
• Palonosetron;
• Passion;
• Perinorm;
• Raglan;
• Rondaset;
• Stronon;
• Ciel;
• Torekan;
• Trifluoperazine;
• Triftazine;
• Tropindol;
• Tropisetron;
• Ceruglan;
• Cerucal;
• Emend;
• Emeset;
• Emetron;
• Etaperazine.

Recall of a gastroenterologist

My patients are patients with various problems from the gastrointestinal tract. Belching, nausea, vomiting, hiccups are one of the most frequent complaints with which they address me. I'm not a fan of antiemetic drugs, but I can not always cope with nausea and vomiting without their help. Motinorm is one of those medicines that I do not like to assign to patients. This is due to the fact that too often in my practice there have been adverse reactions to it. These were skin rashes with itching, and dry mouth, with unbearable thirst, and headaches. In all cases, Motinorma had to be discontinued, so I do not appoint it now.

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