Gepatrombin - instructions for use, reviews, analogs and formulations (ointment and gel 50 000 IU, rectal suppositories D) for the treatment of hemorrhoids, varicose veins and thrombophlebitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Hepatrombin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Hepatrombin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Gepatrombin in the presence of existing structural analogues. Use for the treatment of hemorrhoids, varicose veins and thrombophlebitis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Hepatrombin - combined preparation with antithrombotic, anti-inflammatory and tissue regeneration-improving action for external use.

Heparin is an anticoagulant of direct action. When topical application of Heparin prevents the formation of blood clots, has anti-edematous and anti-inflammatory effect, improves local blood flow.

Allantoin has an anti-inflammatory effect, stimulates metabolic processes in tissues and promotes cell proliferation.

Dexpanthenol improves the absorption of heparin, stimulates granulation and epithelialization of tissues.

Prednisolone - glucocorticosteroid (GCS), has anti-inflammatory, antiexudative and anti-allergic effect, reduces itching, burning sensation, pain in the anorectal area.

Lauromacrogol 400 (polidocanol) has a local anesthetic effect and provides sclerosis of hemorrhoids.

Composition

Heparin sodium + Allantoin + Dexpanthenol + excipients.

Heparin sodium + Prednisolone acetate + Lauromacrogol 400 (polydocanol) + excipients (Gepatrombin G).

Heparin sodium + Dimethylsulfoxide + Dexpanthenol + excipients (Hepatrombin C).

Pharmacokinetics

Heparin

After absorption, biotransformed in the liver (partly by the enzyme hepatic heparinase) and in the reticuloendothelial system. It is excreted by the kidneys.

Prednisolone

Prednisolone after absorption is biotransformed in the liver. About 1% is excreted in the urine unchanged.

Indications

• thrombosis;
• thrombophlebitis;
• external and internal hemorrhoids;
• thrombophlebitis of the veins of the anus;
• phlebeurysm;
• trophic ulcers of the lower leg (for ointment);
• sports injuries;
• tenosynovitis;
• inflammatory infiltrates;
• fistulas, eczema and itching in the anus;
• cracks in the anus.

Forms of release

Gel and ointment for external use 30 000 and 50 000 IU.

Ointment and suppositories rectal (Gepatrombin G).

Instructions for use and how to use them

Hepatrombin

A column of ointment 5 cm long is applied to the affected areas 1-3 times a day.

In cases of veins, the drug is used in the form of dressings with ointment.

When trophic ulcers ointment is applied in the form of a ring about 4 cm wide.

With diseases of the veins of the lower extremities, the ointment is applied with light massaging movements in the direction from the bottom to the top, a single dose is recommended to be rubbed not completely, but in separate portions.

The gel is applied to the skin with a thin layer, rubbing lightly with massaging movements from the bottom up. If gel is used for thrombosis and thrombophlebitis, massaging is not recommended.

Hepatrombin G

Ointment is applied to the affected areas with a thin layer 2-4 times a day; after the disappearance of painful sensations - 1 time per day for 7 days.

Rectal suppositories are administered 1-2 times a day after defecation.

To insert the ointment into the rectum, a screw-on tip is used, which is injected into the rectum and a small amount of ointment is squeezed out by lightly pressing the tube.

Side effect

• allergic reactions (skin rash, skin hyperemia, urticaria, angioedema);
• hyperemia of the skin;
• with long-term use and / or when applied to large surfaces, systemic side effects are possible.

Contraindications

• bacterial, viral, fungal skin lesions;
• tuberculosis;
• syphilis;
• skin tumors;
• reactions to vaccination;
• predisposition to bleeding;
• 1 trimester of pregnancy (Gepatrombin G);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug Gepatrombin G is contraindicated for use in the first trimester of pregnancy.

Pregnancy and lactation (breast-feeding) Gepatrombin the content of sodium heparin 300 U / 1g possible in cases when the expected advantage of therapy for mother exceeds the potential risk to the fetus or infant.

These Gepatrombin the possibility of applying the content of sodium heparin 500 IU / 1 g during pregnancy and lactation provided.

special instructions

When applying a large amount of the drug on the damaged skin or mucous membranes, the regeneration processes slow down.

Included in the other ingredients of the gel Hepatrombin essential oils have antimicrobial and analgesic effect.

Drug Interactions

Data on drug interaction of the drug are not provided.

Analogues of the drug Gepatrombin

Structural analogs for the active substance:

• Gepalpan.

Analogues on the therapeutic effect (means for treating hemorrhoids):

• Avenok;
• Agiolax;
• Aurobin;
• Aescin;
• Bisacodyl;
• Butadione;
• Vasoket;
• Venarus;
• Veno-comfort;
• Venoruton;
• Heparoid Lechiva;
• Hepatrombin G;
• Ginkor procto;
• Hyposol;
• Derinat;
• Detraleks;
• Diovenor 600;
• Doloproct;
• Dulcolax;
• Laxatin;
• Laxigal;
• Metovit;
• Metrogil;
• Mukofalk;
• Natalside;
• Nefluen;
• Nigepan;
• Novocaine;
• Olesesin;
• Papaverine;
• Parebal;
• Piolizin;
• Posterizan;
• Pramoxin;
• Procto Glivenol;
• Proctosan;
• Proctosedil;
• Proctosedil M;
• Simpletons;
• Antihemorrhoidal collection;
• Regulax Picosulphate;
• Relief Ultra;
• Romazulan;
• Romfalak;
• Rutin;
• Symmetrad;
• Software;
• Stress formula with iron;
• Sulgan;
• Troxerutin Lechiva;
• Tyqveol;
• Ultraproject;
• Fiberleks;
• Ferrograduum;
• Flebodia 600;
• Heferol;
• Escuzan;
• Escolus;
• Ethoxysclerol.

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