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Adelphan - instructions for use, reviews, analogs and form of release (Ezidrex tablets) medicines for the treatment of hypertension and depression in adults, children and pregnancy. Composition and interaction with alcohol

Adelphan - instructions for use, reviews, analogs and form of release (Ezidrex tablets) medicines for the treatment of hypertension and depression in adults, children and pregnancy. Composition and interaction with alcohol

In this article, you can read the instructions for using the drug Adelphane. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Adelfan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Adelfan in the presence of existing structural analogues. Use to treat hypertension and reduce blood pressure in adults, children,as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

 

Adelphane - is a combination of antihypertensive components that have different points of application and mutually complementary antihypertensive effects of each other.

 

Reserpine causes depletion of the catecholamine depot in the endings of postganglionic sympathetic nerves and in the central nervous system. As a result, the ability to deposit catecholamines is disrupted for a fairly long period of time. Depletion of catecholamine stocks leads to impairment of impulse transmission in the endings of sympathetic nerves, which in turn leads to a decrease in the tone of the sympathetic nervous system (the activity of the parasympathetic nervous system does not change). Thus, reserpine reduces the elevated blood pressure and heart rate. In addition, reserpine causes sedation. Reserpine also depletes the reserves of other neurotransmitters, incl. serotonin, dopamine, neuropeptides and adrenaline in the central and peripheral neurons. These effects of reserpine may play a role in the realization of its pharmacological effects and antihypertensive effects.

 

After taking reserpine, its antihypertensive effect develops slowly; The maximum effect is achieved only after 2-3 weeks and is maintained for a long time.

 

Dihydralazine sulfate is an arterial vasodilator, reduces the tone of the smooth muscles of arterial vessels (predominantly arterioles) and reduces OPSS. The mechanism of this action at the cellular level remains unclear. In a greater degree, the vascular resistance decreases in the vessels of the heart, brain, kidneys and other internal organs and to a lesser extent in the vessels of the skin and skeletal muscles. If the decrease in blood pressure is not of a pronounced nature, the blood flow in the enlarged bloodstream generally increases. The predominant expansion of arterioles, rather than venules, reduces the severity of orthostatic hypotension and contributes to an increase in cardiac output.

 

Vascular expansion, leading to a reduction in blood pressure (mostly diastolic than systolic), is accompanied by a reflex increase in heart rate, stroke volume and cardiac output. Reflex increase in heart rate and cardiac output can be leveled by combining dihydralazine with reserpine, which suppresses the sympathetic nervous system.

 

Hydrochlorothiazide - thiazide diuretic - acts in the cortical segment of the Henle loop and the distal sections of the renal tubules. It inhibits the reabsorption of chloride and sodium ions (due to antagonistic interaction with the transport enzyme NaCl) and enhances the reabsorption of calcium ions (the mechanism is unknown). An increase in the amount and / or rate of intake of sodium and water ions into the cortical segment of the collecting tubes leads to an increase in the secretion and excretion of potassium and hydrogen ions.

 

In patients with normal renal function, an increase in diuresis is observed after a single application of hydrochlorothiazide at a dose of 12.5 mg. The increase in urinary excretion of sodium and chlorine and a slightly less pronounced increase in potassium -urease depend on the dose of hydrochlorothiazide. After taking the medication, diuretic and natriuretic effects start within 1-2 hours, peak at 4-6 hours, and last for 10-12 hours. Diuresis caused by thiazides first leads to a decrease in the volume of circulating plasma, cardiac output, and systemic blood pressure. It is possible to activate the renin-angiotensin-aldosterone system. With long-term use of hydrochlorothiazide, the maintenance of the hypotensive effect is provided, probably, due to the reduction in OPSS.Cardiac output returns to baseline values, a small decrease in plasma volume and an increase in plasma renin activity persist.

 

Composition

 

Reserpine + Dihydralazine sulfate (hydrated) + auxiliary substances.

 

Reserpine + Dihydralazine sulfate (hydrated) + Hydrochlorothiazide + auxiliary substances (Adelphan Ezidrex).

 

Pharmacokinetics

 

Reserpine is rapidly absorbed after ingestion.

 

Dihydralazine is rapidly absorbed after oral administration. In the blood plasma, dihydralazine is mainly in the form of unchanged dihydralazine and hydrazone substances formed as a result of the metabolism of the basic substance. Approximately 10% of dihydralazine is in the blood plasma in the form of hydralazine.

 

Hydrochlorothiazide after intake is absorbed by 60-80%. Changes in absorption due to food intake are not clinically important.

 

Hydrochlorothiazide accumulates in erythrocytes.

 

Reserpine is metabolized in the intestine and liver. The main metabolites are methyl reserpate and trimethoxybenzoic acid. Dihydralazine is metabolized to a large extent by oxidation (with the formation of hydrazones) and acetylation. Hydrochlorothiazide is metabolized to a very small extent.Its only metabolite found in trace amounts is 2-amino-4-chloro-M-benzenedisulfonamide.

 

During the first 96 hours after ingestion, 8% of the reserpine dose is excreted by the kidneys, mainly in the form of metabolites, and 62% through the intestine, mostly unchanged.

 

After oral administration, about 46% of the dose of dihydralazine taken is withdrawn within 24 hours, mainly in the form of metabolites, mainly through the intestine. About 0.5% of the dose is detected in the urine as an unchanged substance.

 

In patients with normal renal function, the excretion of hydrochlorothiazide is almost exclusively performed by the kidneys. In general, 50-75% of the dose taken internally is excreted in the urine unchanged.

 

Indications

  • arterial hypertension.

 

Forms of release

 

Pills.

 

Instructions for use and dosing regimen

 

The drug is taken with food and washed down with water.

 

The dose of the drug should be selected individually. Treatment begins with the appointment of a minimal dose, which can be gradually (not more often than every 2-3 weeks) to increase, depending on the patient's response to treatment. The daily dose is usually 1-3 tablets. The maximum daily dose is 3 tablets. The frequency of taking the drug is 2-3 times a day.

 

If adequate blood pressure control can not be achieved, the treatment should be reviewed and, possibly, switched to a drug of another pharmacological group (beta-blocker, slow calcium channel blocker, ACE inhibitor).

 

In elderly patients, as well as in patients with impaired hepatic function, a single dose of the drug or an interval between its prescriptions should be established with caution, taking into account the required clinical response to treatment and tolerability.

 

Side effect

  • dry mouth;
  • increased secretion of gastric juice;
  • increased salivation;
  • nausea, vomiting;
  • diarrhea;
  • increased appetite;
  • ulcer formation;
  • gastrointestinal bleeding;
  • sinus bradycardia;
  • edema;
  • arrhythmias;
  • pain behind the sternum, suggesting angina pectoris;
  • orthostatic hypotension;
  • flushes of blood to the face;
  • fainting;
  • heart failure;
  • disorders of cerebral circulation;
  • edema of the nasal mucosa;
  • dyspnea;
  • nose bleed;
  • dizziness;
  • depression;
  • irritability;
  • nightmarish dreams;
  • increased fatigue;
  • extrapyramidal disorders (including parkinsonism);
  • headache;
  • alarm status;
  • violation of concentration of attention;
  • stupor;
  • violation of orientation;
  • cerebral edema;
  • violation of potency and ejaculation;
  • dysuria;
  • glomerulonephritis;
  • increase in body weight;
  • decreased body weight;
  • increased secretion of prolactin;
  • galactorrhea;
  • gynecomastia;
  • swelling of the mammary glands;
  • blurring of vision;
  • hyperemia of the conjunctiva;
  • lacrimation;
  • hearing impairment;
  • eczema;
  • itching;
  • decreased libido;
  • anemia, thrombocytopenia.

 

Contraindications

  • depression (currently or in history);
  • Parkinson's disease;
  • epilepsy;
  • electroconvulsive therapy;
  • peptic ulcer of the stomach and duodenum in the phase of exacerbation;
  • ulcerative colitis;
  • pheochromocytoma;
  • concomitant or recent treatment with MAO inhibitors;
  • systemic lupus erythematosus (idiopathic);
  • severe tachycardia and heart failure on the background of high cardiac output (including with thyrotoxicosis);
  • heart failure due to mechanical obstruction (including the presence of aortic or mitral stenosis or constrictive pericarditis);
  • isolated right ventricular failure due to pulmonary hypertension ("pulmonary" heart);
  • anuria, marked renal failure (creatinine clearance less than 30 ml / min);
  • liver failure;
  • refractory hypokalemia, hyponatremia, hypercalcemia;
  • hyperuricemia with clinical manifestations;
  • pregnancy;
  • children under 18 years of age (efficacy and safety not established);
  • hypersensitivity to reserpine and related substances, dihydralazine or other hydrazinophthalazines, hydrochlorothiazide or other sulfonamide derivatives.

 

Application in pregnancy and lactation

 

Adelphan is contraindicated in pregnancy for the following reasons.

 

Reserpine, in the case of its appointment before childbirth, can cause a pronounced drowsiness in the newborn, swelling of the nasal mucosa and anorexia. The effect of thiazide diuretics, incl. hydrochlorothiazide, resulted in the fetus and newborn thrombocytopenia. Since thiazide diuretics do not prevent the onset and do not affect the severity of the manifestations of toxicosis of pregnant women (edema, proteinuria, hypertension), they should not be prescribed for this indication.

 

Reserpine, dihydralazine and hydrochlorothiazide penetrate into breast milk. Reserpine in a newborn baby may cause the reactions described above. Hydrochlorothiazide can inhibit lactation. It is not recommended to use Adelfan during lactation.

 

There have been no studies to study the influence of Adelphan on reproductive performance in animals.

 

special instructions

 

Patients who underwent myocardial infarction should not be prescribed dihydralazine until the stabilization period is over after myocardial infarction. As with the administration of any antihypertensive drugs with a pronounced hypotensive effect, special care should be taken when administering Adelphan to patients with coronary and cerebral atherosclerosis. In these cases, a sharp decrease in blood pressure should be avoided. this can lead to a decrease in blood flow. The following precautions apply not only to each component alone, but also to the preparation of Adelphan as a whole.

 

Since reserpine increases motility and secretion in the digestive tract, caution should be exercised when it is used in patients with peptic ulcer of the stomach and duodenum in anamnesis, as well as in patients with erosive gastritis and cholelithiasis. Care should also be taken in patients with heart failure, sinus bradycardia, conduction disorders, as well as in patients who have recently undergone myocardial infarction.

 

Care should be taken in patients with suspected coronary artery disease. Dihydralazine-induced tachycardia can lead to an attack of angina and changes in the ECG, indicating myocardial ischemia. In some cases, the connection of myocardial infarction with the intake of dihydralazine was not excluded.

 

Adelfan should be avoided (especially if used with potassium or with potassium-sparing diuretics) for patients taking ACE inhibitors. As with the use of other thiazide diuretics, caution should be exercised in patients with diabetes mellitus and gout.

 

When signs of depression appear, the drug should be immediately discontinued, since there is a risk of suicidal actions. Depression caused by reserpine (especially when using Adelfan in high doses) can be severe enough to provoke suicidal actions. It can persist for several months after drug withdrawal.

 

The use of dihydralazine can lead to a delay in sodium and water in the body and, consequently, the development of edema and a decrease in diuresis.

 

It is required to systematically monitor the condition of patients with impaired liver function, given the possibility of the occurrence of rare but serious side effects of dihydralazine on the part of the liver. It should also be taken into account that even minor violations of the water-electrolyte balance caused by the thiazide diuretic can provoke hepatic coma, especially in patients with cirrhosis of the liver. At present, there are few reports of cases of lupus-like syndrome associated with the intake of dihydralazine. The mild forms of this syndrome are manifested by arthralgia, sometimes accompanied by fever and skin rashes; with the withdrawal of the drug, these symptoms pass by themselves. In more severe cases, the clinical picture is similar to that of systemic lupus erythematosus; complete disappearance of symptoms can be achieved only with long-term treatment of SCS. The frequency of this syndrome is directly related to the dose and duration of treatment. In this regard, for the duration of maintenance therapy is recommended to use the minimum effective dose.

 

During treatment with dihydralazine, it seems advisable to determine the antinuclear factor in the blood plasma every 6 months. In the case of detection of an antinuclear factor, it is necessary to systematically determine its titers. If clinical manifestations of lupus-like syndrome develop, the drug should be immediately withdrawn. Reserpine should be discontinued at least 7 days before electroconvulsive therapy.

 

The cancellation of reserpine before the operation is not a guarantee that during the operation there will be no instability of hemodynamics. It is important to warn an anesthesiologist that the patient is taking reserpine, and took this into account when administering the patient. There are cases of a decrease in blood pressure in patients receiving drugs rauwolfia. During the surgical intervention in patients receiving dihydralazine, there may be a marked decrease in blood pressure.

 

Against the background of hydrochlorothiazide, hypokalemia develops. Hypokalemia can increase the sensitivity of the myocardium or strengthen the heart's response to the toxic effects of digitalis preparations. The risk of hypokalemia is increased with cirrhosis of the liver, rapidly developing diuresis, inadequate intake of potassium with food, concomitant therapy with GCS,stimulants of beta2-adrenergic receptors or ACTH. With the purpose of timely detection of possible electrolyte balance disturbances it is necessary to determine the electrolyte content in the plasma at the beginning of treatment and at certain intervals during the treatment.

 

Nonspecific manifestations of violations of electrolyte balance, observed in a number of cases, were dry mouth, thirst, weakness, drowsiness, anxiety, muscle aches and cramps, muscle weakness, decreased blood pressure, oliguria, tachycardia, nausea.

 

Thiazide diuretics cause a decrease in calcium excretion. Several patients who received long-lasting thiazide diuretics had pathological changes in the parathyroid gland, accompanied by hypercalcemia and hypophosphatemia. In the case of hypercalcemia, additional tests are needed to clarify the diagnosis. There were no complications that are usually associated with hyperparathyroidism, such as the formation of kidney stones, bone resorption, peptic ulcers.

 

Thiazide diuretics cause an increase in urinary excretion of magnesium, which can lead to hypomagnesemia.

 

When used in high doses, thiazide diuretics can cause a decrease in glucose tolerance and lead to an increase in plasma concentrations of cholesterol, triglycerides and uric acid.

 

The use of reserpine affects the results of the determination in urine of 17-ketosteroids and 17-hydroxycorticosteroids by a colorimetric method, leading to an underestimation of these results.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Adelfan can disrupt the patient's ability to respond quickly, especially at the beginning of treatment. As with the appointment of other antihypertensive drugs, patients managing vehicles and mechanisms should be warned about the possibility of reducing the speed of psychomotor reactions, and be careful.

 

Drug Interactions

 

The hypotensive effect of Adelphan is enhanced by the simultaneous administration of other antihypertensive drugs: guanethidine, alpha-methyldopa, beta adrenoblockers, vasodilators, slow calcium channel blockers, ACE inhibitors.

 

A number of interactions associated with individual components of the drug are also possible.

 

Reserpine

 

It is necessary to abolish MAO inhibitors at least 14 days before starting reserpine therapy.If it is necessary to administer MAO inhibitors to a patient receiving reserpine, MAO inhibitors should be given at least 14 days after the withdrawal of reserpine. With simultaneous application of reserpine and MAO inhibitors, hyperactivity, hypertensive crisis are possible.

 

Reserpine increases the depressing effect on the central nervous system alcohol, funds for general anesthesia, some antihistamines, barbiturates and tricyclic antidepressants. Reserpine weakens the action of levodopa. The simultaneous use of reserpine and tricyclic antidepressants can reduce the hypotensive effect of reserpine.

 

Reserpine should be discontinued a few days before the scheduled surgery to avoid excessive BP reduction during general anesthesia. The administration of reserpine in combination with antiarrhythmic drugs or digitalis preparations can lead to sinus bradycardia.

 

Reserpine may enhance the effects of epinephrine (adrenaline) or other sympathomimetic agents (Caution should be exercised while the use of antitussives, nasal drops, eye drops).

 

Dihydralazine sulfate

 

The simultaneous use of tricyclic antidepressants, neuroleptics, as well as ethanol-containing drugs (as well as alcohol) can enhance the hypotensive effect of dihydralazine. The administration of dihydralazine shortly before or shortly after administration of diazoxide may cause a marked decrease in blood pressure.

 

Hydrochlorothiazide

 

With the simultaneous use of hydrochlorothiazide and lithium preparations, it is possible to increase the concentration of lithium in the blood, so in this case, a systematic control of the level of lithium in the blood is necessary. In cases where lithium preparations cause polyuria, hydrochlorothiazide can cause a paradoxical antidiuretic effect. Hydrochlorothiazide can enhance the effects of nondepolarizing muscle relaxants.

 

The hypokalemic effect caused by diuretics can be enhanced with simultaneous application of GCS, ACTH, amphotericin, carbenoxolone. Hypokalemia and hypomagnesemia (undesirable effects of thiazide diuretics) can contribute to the development of cardiac arrhythmias in patients receiving cardiac glycosides.

 

When using hydrochlorothiazide in patients with diabetes mellitus, it may be necessary to adjust the doses of insulin and oral hypoglycemic drugs.

 

Simultaneous administration of NSAIDs (incl.indomethacin) can weaken the diuretic, natriuretic and antihypertensive effects of hydrochlorothiazide. There are some reports of impaired renal function in predisposed patients.

 

The absorption of hydrochlorothiazide is disturbed in the presence of anion-exchange resins. The absorption of hydrochlorothiazide from the digestive tract with simultaneous single application of colestyramine and colestipol decreases by 85% and 43%, respectively, due to binding to these compounds.

 

The simultaneous use of thiazide diuretics (including hydrochlorothiazide) may increase the risk of Allopurinol hypersensitivity reactions, increase the risk of side effects of amantadine, increase the hyperglycemic effect of diazoxide, reduce renal excretion of cytotoxic agents (including cyclophosphamide, methotrexate) and intensify their myelosuppressive effect.

 

Anticholinergic drugs (including atropine, biperiden) can increase the bioavailability of hydrochlorothiazide, which is associated with a decrease in motor activity of the gastrointestinal tract and the rate of gastric emptying.

 

Simultaneous intake of hydrochlorothiazide with vitamin D or calcium preparations can lead to an increase in the level of calcium in the blood.

 

With the simultaneous use of hydrochlorothiazide and cyclosporine, the risk of developing hyperuricemia and gout increases.

 

There are reports of the development of hemolytic anemia with simultaneous administration of hydrochlorothiazide and methyldopa preparations.

 

Analogues of the drug Adelphan

 

Structural analogs for the active substance:

  • Adelphan Ezidrex.

Similar medicines:

Other medicines:

Reviews (45):
Guests
Natasha
As such, there are no pressure problems, it usually keeps within 120/70. The husband on this occasion even jokes: "With such pressure you even run into space". But sometimes, albeit extremely rarely, there are sharp jumps up, here for such emergency cases I keep in the medicine cabinet adelphan. As a matter of fact it is, of course, self-medication, nobody wrote this medication to me, it was just the first time that such a pressure jump happened to me at work, and the nurse in the first-aid post gave me an adelfan pill, the pill helped, after that I went to the pharmacy and bought a plate 10 pcs.) Just in case.But as I said, cases like this, fortunately, are rare. Last, for example, was last year, when the daughter of the USE handed over. I perenernvnichala then terribly, that's the pressure and jumped to 140/100.

Adelfan, of course, helped, did not disappoint. Two tablets, drunk with a break of several hours, quickly brought the pressure back to normal. Of the side effects, she noticed only an unusual dry mouth, which she could not wash down with anything. As a result, I did not sleep well at night, because I kept running to the toilet. Of course, my case is not indicative. Adelphan - a serious medicine and the consequences of his uncontrolled reception can also be serious, so it's better if he still writes out a doctor.
Guests
Olezhka
Yeah, while reading the description of this drug, probably, the pressure itself has risen - so abstruse it is written, is it really impossible to write a simple language for those who do not have medical education?
But this by the way, and in general I want to say: his wife was Adelphan, so her blood pressure was greatly reduced even from one tablet of 10 mg. Before that, saw Enap, but he stopped acting.
Administrators
admin
Olezhka, Instructions to the preparations are written for specialists. The use of recommendations by ordinary people without consulting with doctors can lead to sad consequences for health.
Guests
Anatoly
Now I'm 70 years old. Increased pressure tormented about 14 years. Then I had a stroke on the background of sharply increased pressure (210-110), but I quickly recovered and recovered. During these years I tried more than 20 different medicines for pressure, but they all helped for a short time. For several years I have been taking Adelfan Ezidreks, who always helps me. They say that this medicine is already the last century, but if it helps, why should we give it up!
Administrators
admin
AnatolyDo not give up the medications that help you. Even if it is a placebo or the last century, the more cheap. The goal of treating high blood pressure is to lower it. Why try to change a person a drug checked by him, if everything goes well. No pobochki, reduces the pressure and keeps it for a period of time until the next reception - take and do not think about anything.
Guests
Tatyana
A few days the high pressure keeps, it reached 170/103 although before that it was always lowered. They called for an ambulance, but the injections did not help for long. The doctor advised my mom (she also has high blood pressure) to take adelphane along with a no-shpa tablet, like an ambulance. I accepted and my pressure has already dropped to 123/65. The truth is a headache and a pulse 91 (heart pounding furiously). I drank strong tea so that it did not go below. The effect is immediate from the drug, but before that nothing helped, the pressure dropped max by 3 units.
Guests
Nina Vasilievna
I use Adelphan for 10 years. So, accidentally, my head got sick at work, the nurse measured the pressure, gave me an adelphan, andipal and aspirin tablet. I felt much better. Since then, so much pressure and shoot down. The last time I went to the drugstore for medicine, and I was told that adelphan was prescribed only by the doctor, and the doctor says that such a thing is not being treated anymore, try other drugs. And how should I try them, I'm not a doctor. I had previously been prescribed other drugs by doctors, but all was in vain. Such a deadlock situation.
Administrators
admin
Nina Vasilievna, Insist on extracting the drug that suits you. If others have tried, but there is no effect, then the organism does not see any sense of rape. Obliged to prescribe the drug you need.
Guests
Tatyana.
This drug helps and very well. Can I apply it for a long time or not?
Administrators
admin
Tatyana., I do not appoint such ancient medications, but if a person comes to Adelphane and everything is normal in terms of indicators - I do not dissuade. From experience I can say that they have been sitting on it for years and have not seen any pobochki. But this, of course, to someone that will go.
Guests
Galina
Constantly from the pressure I take other drugs. But with the pressure jump, Adelphan Ezidrex and paposal tablet were taken. It was a great help. But adelphan disappeared from pharmacies! Here's the trouble!
Guests
Vyacheslav
I accept adelphan together with captopril under the tongue in emergency cases for more than 17 years.Helps to be reliable, side-effects can not remember tried a bunch of modern drugs - the result is bad.
Guests
frets
Who knows where the adelphan has gone and what are the prospects for its appearance ?! Pharmacists in the pharmacies are suspiciously silent ...
Administrators
admin
frets, Unknown. In the pharmacies of this drug is really not: (
Guests
Pensioner
Glory to Adelphan! The husband received from high blood pressure Enap - for 2 months of taking swollen feet, sometimes in the lower back, he began to suffocate, he could not lie at all, he did not sleep at night. I refused to go to doctors-such a one, no one believes. Has forced to stop to drink Enap and has given adelfan, the blessing, he in Moscow while is and without the prescription. I hoped that though the swelling of the legs would fall. The effect is striking: the edema of the feet immediately subsided, a week passed all the internal edema, passed the sniff, sleeps at night. Continues to take hell. The pressure is normal.
Guests
Galina.
I'm in a panic about what to do. Adelfan disappeared.I took it as an "ambulance" rarely. I accept Enap - 10mg in the morning and in the evening, regardless of the pressure, even at a pressure of 120/70. This is my pressure. Appointment of doctors. Adelfan at the pressure jump - hood and corinfar do not help. What now to do and where to look.
Administrators
admin
Galina.Judging by the reviews, Adelphan really disappeared from the Russian pharmaceutical market. It is probably necessary to look for a substitute, although the consumers of this medication had enough. True prospects for the drug was not, as young people are planted on other drugs, more effective - respectively, and more expensive.
Guests
Maxiban
Now listen to what I say! Better it's nothing! He saves me and cures me of pressure and absence, than other helpless like normodipine and others! I after the operation of AVM brain tumor 2h2 cm left the temporal part. It's been 2.6 years. from the smells of sharp and concentrated flavors (acid, salt, sour, sour, spicy) the pressure rises and the roof is badly ridden. The pressure 150x90 happens more.So the principle of treatment is that I had a large cerebral vessel cut from small vesicles and stuck with a cautery soldering iron. I have a large vessel that has scars from the vessels that are cut off. So if I eat something wrong or smells sharp my vessel gets a spasm (strains), and the pill's principle of pressure is to stretch the vessel and soften it (soothes the vessel). I use it 1 time when it's badly done and I'm back to normal again. I noticed that my head hurts, it can make me sick and the heart of tachycardia rises so I can not use it much. 1 time for 2 -3 days. I can not do without him, others do not help me, but make me worse. I hear bad news, they say here that he is not in pharmacies recourse but how then it will be bad for me to live wassat
Guests
Michael.
A good drug, often helps out, but is gone. He is not in pharmacies. This was in the past year, first disappeared, and then appeared, but already more expensive in 2 times.
Guests
Tatyana
I take many years. I tried other, but for me adelphan is the most optimal. The doctors argued that this drug is no longer relevant, but for me it is better than others.The problem is that he has disappeared since the month of December. We will hope that he will appear.
Guests
leto
I constantly accept Concor. Adelfan - only with hypertensive crisis. Adelfan helps better than all the drugs that doctors advised me. Tried Nifedipine, the head immediately splits, and the pressure decreases slowly, the next day I lay in a layer, tk. the pressure is low. Kapoten drank earlier all the time two years, the pressure not only did not decrease, but on the contrary it began to rise even higher, the doctors canceled. Enap drank a long time, stopped helping. Now the doctor prescribed the German drug Physiotense, tried it under the crisis, the result is the same as under Nifedipine. Adelfan acts as a diuretic, and soothing, and vasodilating. Any drugs have side effects if they are taken continuously, and if Adelphane is taken only with a crisis and it helps better than other drugs, why was it abandoned? Or did someone pay a lot to promote more expensive inefficient drugs to Russia?
Guests
Elena
Many years with hypertensive crises used adelfan. And many years from doctors only I hear about how harmful it is. This "harm" did not feel on myself. Since December he disappeared in pharmacies. Just upset. From kapotena, captopril, kordafleksa one "harmfulness" - an allergy. I do not even know what else to try. Doctors convince always that no one accepts it any more, but judging by the reviews, I'm not the only one who is so crazy taking adelphan. Some conspiracy is just a pharmacist-physician.
Guests
Galina Anatolyevna
For me, adelphan is an ambulance. I am 74 years old. Constantly drink lopaz 5 mg for many years. I adjust the dosage all the time, as a very low pulse of 55-58 became, then I drink 2.5 mg for several days until the pressure starts to rise. But when you switch to 5 mg, the pressure first rises only. I try to drink at the same time and before eating. Sometimes I forget to take, or a very large load and then there can be jumps up that are difficult to reduce. And then the magic wand is adelphan, one tablet and all. And the pressure reduces and excess water expels from the body. Tried a hood or captopril. Pressure is reduced, but a wild headache the next day to faintness.Claphelin is even more effective. A good doctor went to meet him and 20 years ago he prescribed a prescription for one package. I also did not use half of it. Sex tablets or even quarters - under the tongue and go to bed for an hour. The only thing, then the dryness in the mouth. But the pressure is stably normal.
Guests
Ahmad
Return adelphan am
Guests
Antonina Ivanovna
I am 66 years old and I have long been using adelphan as an ambulance, because The pressure is rarely elevated and always helps never fail. I'm from Ukraine, we used to have it also disappeared from pharmacies, my sister from Russia brought, and now we have. So the drug is time-tested!
Visitors
nerenga
Galina., where do you live?
I have specially registered here to find out the situation on adelphan. It is extremely necessary for me.
I found a site that carries this drug from Ukraine, it's there. They sell it in Moscow for 6000 rubles. (250 pieces of packing).
To me it is very expensive, I search with whom to buy in half or for three.
Guests
Vitaliy
Galina, we wanted to buy, are you sure of the originality of the product?
Guests
Semeko Julia
I also need adelphan, but I can not find it anywhere in Rostov-on-Don. In pharmacies they say that it is cheap and it is not profitable to sell it! This is such a medical secret. Yes, doctors do not recommend it, but it really helps me, as well as millions of other hypertensives!
Guests
olga
Adelphan accepted 15 years. Very good drug. Now the doctor is picking up a replacement. Already tried three drugs - allergic and side reactions. Very exhausted. When the adelphan is on sale ...
Guests
Yulia Kovaleva
Please return the adelphan, he always helps me. I drink a long time, other medicines do not help. I accept egilok, indapamid, panangin. But adelphan helps well with crises. Therefore, it is needed as an ambulance, please return it to the pharmacies of Volgograd.
Guests
Marina Mepchislavovna
Wonderful drug Adelphan! I rarely have pressure jumps and one-fourth of a pill helps me. The pressure is lowered literally for 15-20 minutes. No longer rises.Absolutely no side effects did not observe. I have been using it for 20 years. it is cheap and you do not need to take it for life, but pharmoligarchs do not benefit from it. People do not give a damn about them.
Administrators
admin
Eugene L., Your advertising offer for the sale of counterfeits has not been published, since any sale past the pharmacy network is considered a priori fake. At us many drugstores can not brag of legal origin of sold medicines, and trade with them and for a long time. So do not publish such advertisements any more, otherwise I'll write a ban. To date, Adelphan has been removed from production and no new information on the launch has been received.
Guests
ugly love is paulown
For me, adelphan is also an ambulance, and it seems like there is a sale. At least it was in the summer.
Guests
Alex.
Only in Spain I bought an analog of adelfan.
Guests
Galina
Yesterday, the pressure increased by 200 per 100.I drank the hood as the doctor said, but the pressure fell slightly. This morning, 190 to 100. I found an adelfan in my mother's first aid kit. I drank half a tablet and a pressure of 150 to 90. My mother regularly took adelphan and lived up to 90 years, although her whole life was hypertensive. Neighbor's grandmother all her life drank adelphan half a tablet a day for the prevention of hypertension. She died at the age of 101. I realized that doctors prescribe now all sorts of nonsense just to be more expensive.
Guests
Galina
Today I was with a doctor and she told me that Adelphan is the last century. Adelfana 10 pieces. enough for a year, or even more. But it costs a penny. And that they wrote a hundred rubles. That's the difference.
Guests
Tatiana Vasilievna
I have been looking for a miracle pill Adelphan for 2 years now. They are not here. Have written out Captopril is not a medicine, and soda - under a skin the skin climbs day 2, then hot I can not eat. I'm very interested - why not explain the absence of Adelfan? India is a friend country. So why? Import replacement is inappropriate, because. there is an account of life and death. I have AD 180 \ 100 \ 115 and often at night due to the fact that there is no Adelfan I call an ambulance, but she does not do anything worthwhile either.Even an injection. Hypothiazide and phenazepam under the tongue and all. A captopril AD increases and fear begins for life. Well, why not Adelfan? Bring it back to the pharmacies. You work for the people.
Administrators
admin
Tatiana Vasilievna, I want to answer the words of the classic: They are too far from the people. On a penny a medicine it is more difficult to have a good margin. There are no other explanations for the disappearance, and producers and sellers do not give any explanations about the lack of a drug in pharmacies.
Guests
Love
Who determines the return of adelphan? Who should hear our requests for this drug to be returned to the pharmacies? Hear, please!
Guests
sema cykerman
sema cykerman, Your feedback is not published and advertising of any counterfeit is not necessary for me to send. She still does not get into the Directory and people do not need to fool. Press the tablets of milk powder and sell it under the guise of a drug that is not on sale and the fool can, although not, this is called fraud. Adelfan on sale in Russia is not, and everything else is just a greed for money, besides not cheap at the price,then it's better to replace this drug with any analogue. Cheaper to go, for health exactly.
admin
Guests
Andrei
Good mildly acting drug. Given that our medicine is the promoters of pharmaceutical TNCs, they say that it is ancient. From novodelov I have an allergy, but from adelfan did not notice. Yes, and producers of India, why give the market share to a developing country - we must feed the golden billion.
Guests
Irina.
Mom accepted after trepanation according to the appointment of professor 1/4 for the night. How much time has passed, and replacements can not be found, some abuse. She is already 81.
Guests
galena
Excellent preparation, return.
Guests
Tatyana
Stunning product, what a pity that it stopped buying. All contraindications from other drugs from increased blood pressure. I can not find any medicine, replacing adelphan, I am suffering and only. It was ideal for me. What a pity!
Guests
Tanya
Yes, this is the pharmaceutical agreement! Remember that the former "minister" (without the medical education) of the public was flogging about the effective drug (if you believe Pozner), which seriously helps overseas in diabetes. So, this "minister" Golikov said so roughly: let's start - the whole farm industry will fly. The same goes for adelphan ... Personally, I go and spend all my work at home - climb, hang curtains, bend my knee, when my floors are very high at a high pressure - 200 to 110. So, here ... And I helped only adelphan and only. Sometimes I drink - the pharmacist advised, because the adelphan disappeared - Ukrainian pharmadipine. Once or twice and it ended, this pharmadipine. And the effect of it is worse. Is the Ministry and the current minister thinking about people? They, so obviously after all, need only very expensive developments and business is important in this area for the health and mortality of citizens.

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