En DE FR ES PL
Phosphogliv - instructions for use, reviews, analogs and forms of release (Forte capsules or tablets, injections in ampoules for injections) drugs for the treatment of hepatitis and cirrhosis in adults, children and pregnancy. Composition

Phosphogliv - instructions for use, reviews, analogs and forms of release (Forte capsules or tablets, injections in ampoules for injections) drugs for the treatment of hepatitis and cirrhosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Phosphogliv. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Phosphogliv in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Phosphogliv in the presence of existing structural analogues. Use for the treatment of hepatitis and cirrhosis of the liver in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

 

Phosphogliv combined preparation. Has a membrane-stabilizing, hepatoprotective and antiviral effect.

 

Phosphatidylcholine (the active substance of phospholipids) is the main structural element of cellular and intracellular membranes, capable of restoring their structure and functions in damage, providing a cytoprotective effect. Normalizes protein and lipid metabolism, prevents the loss of hepatocytes of enzymes and other active substances, restores the detoxifying function of the liver, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis of the liver.

 

Glycyrate (glycyrrhizic acid and salts) has an anti-inflammatory effect, inhibits the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, increasing the activity of natural killer cells (Natural killers). Has a hepatoprotective effect due to antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and anti-allergic effects in non-infectious liver lesions.

 

When the skin is damaged due to the membrane-stabilizing and anti-inflammatory effect of the components, it limits the spread of the process and promotes regression of the disease.

 

Composition

 

Phospholipids (lipoid C80, the main component - phosphatidylcholine 73-79%) + Sodium glycyrrhizinate (trisodium salt glycyrrhizic acid) + auxiliary substances.

 

Lipoid PPL-400 + Phospholipids (main component - phosphatidylcholine 73-79%) + Sodium glycyrrhizinate + auxiliary substances (Phosphogliv Forte).

 

Pharmacokinetics

 

Phosphatidylcholine

More than 90% of the ingested phospholipids are absorbed into the small intestine. Most of them are cleaved by phospholipase A to 1-acetyl-lysophosphatidylcholine, 50% of which undergoes reverse acetylation to polyunsaturated phosphatidylcholine during absorption in the intestinal mucosa. Polyunsaturated phosphatidylcholine with a current of lymph enters the blood, from where, mainly, in the high-density lipoprotein linked to the liver. Pharmacokinetics in humans was studied using dilenoleil phosphatidylcholine with a radioactive label - 3H (choline part) and 14C (a residue of linoleic acid).The maximum concentration of H is reached in 6-24 hours, amounting to 19.9% ​​of the prescribed dose; 14С - in 4-12 hours, making 27,9%. The half-life of the choline component is 66 hours, the remainder of linoleic acid is 32 hours. In the stool, 2% 3H and 4.5% -14C are detected; in urine - 6% 3H and the minimum amount of 14C. Both isotopes are absorbed in the intestine by more than 90%.

Glycyrrhizic acid

After oral administration in the intestine under the influence of the enzyme P-glucuronidase, produced by bacteria of normal microflora, an active metabolite is formed from glycyrrhizic acid, P-glycyrrheic acid, which is absorbed into the systemic bloodstream. In the blood, P-glycyrrhetic acid binds to albumin and is almost completely transported to the liver. Isolation of P-glycyrrhotic acid occurs predominantly with bile, in the residual quantity - with urine.

According to experimental data, phospholipids improve the lipophilic properties of glycyrrhizic acid, increasing the intensity and speed of its absorption by more than 2 times.

 

Indications

  • viral hepatitis (acute and chronic);
  • fatty liver degeneration (hepatosis);
  • other liver damage (medicinal, alcoholic, toxic);
  • cirrhosis of the liver;
  • intoxication;
  • psoriasis.

 

Forms of release

 

Capsules (including Phosphogliv Forte), sometimes mistakenly called pills.

 

Lyophilizate for the preparation of a solution for intravenous administration (injections in ampoules for injections).

 

Instructions for use and reception scheme

 

Inside, adults and children over 12 years of age are prescribed 2 capsules 3 times a day. Capsules are taken with food, squeezed with a small amount of liquid.

 

Intravenously slowly, the drug is administered 10 ml 2 times a day in the morning and in the evening for 10 days. Beforehand, dissolve the contents of 1 bottle in 10 ml of water for injection, followed by an oral administration of the drug in the form of capsules.

 

Side effect

  • skin rash;
  • obstruction of nasal breathing;
  • conjunctivitis;
  • cough;
  • transient (transient) increase in blood pressure;
  • peripheral edema;
  • dyspepsia (belching, nausea, bloating);
  • discomfort in the abdomen.

 

If these symptoms occur, stop taking the medication and consult a doctor.

 

Contraindications

  • pregnancy (data on effectiveness and safety is not enough);
  • lactation period (breastfeeding);
  • antiphospholipid syndrome;
  • children's age is less than 12 years (data on efficiency and safety is not enough);
  • hypersensitivity to glycyrrhizic acid, phosphatidylcholine or other components of the drug.

 

Application in pregnancy and lactation

 

The drug Phosphogliv is contraindicated for use in pregnancy and lactation.

 

Use in children

 

Applied in children over 12 years.

 

special instructions

 

The solution for injection can not be mixed with other solutions.

 

Do not use saline or glucose solution to dilute the lyophilizate.

 

When there is a delay in sodium and fluid and hypokalemia, depending on their severity, it is necessary to reduce the dose of the drug and / or to prescribe spironolactone at 50-100 mg per day.

 

In case of high blood pressure should stop taking the drug and see a doctor.

 

Influence on ability to drive vehicles and work with mechanisms

 

The drug does not adversely affect the ability to drive vehicles and perform other work that requires an increased concentration of attention and speed of psychomotor reactions.

 

Drug Interactions

 

The drug interaction of Phosphogliv is not described.

 

Analogues of the drug Phosphogliv

 

Phosphogliv does not have structural analogs for the active substance.

 

Analogues on the therapeutic effect (hepatoprotectors):

  • L-Methionine;
  • S-Adenosylmethionine;
  • Alpha-lipoic acid;
  • Antraliv;
  • Berlition 300;
  • Berlition 600;
  • Betaine citrate;
  • Brentzialle forte;
  • Vitanorm;
  • Hepa-Mertz;
  • Hepatosan;
  • Hepatofalk the plant;
  • Heptor;
  • Heptral;
  • Heptrog;
  • Glutargin;
  • Covechol;
  • Karsil;
  • Karsil Forte;
  • Cryomelt;
  • Legalon;
  • Livedoksa;
  • Livolife Forte;
  • Lipoic acid;
  • Lipoid PPL 400;
  • Lipoid C 100;
  • Maxar;
  • Methionine;
  • Milife;
  • Moliksan;
  • Octolipen;
  • Ornitsetil;
  • Resalute Pro;
  • Silegon;
  • Silibinin;
  • Sylimar;
  • Silymarin;
  • Sirepard;
  • Thiolipone;
  • Tiotriazolin;
  • Tyqveol;
  • Urdoks;
  • Urso 100;
  • Ursodez;
  • Ursodeoxycholic acid;
  • Ursodex;
  • Ursuliv;
  • Ursor;
  • Ursosan;
  • Ursofalk;
  • Phosphogliv Forte;
  • Phosphontsiale;
  • Hepabos;
  • Holudexan;
  • Exxhol;
  • Erbisol;
  • Essentiale N;
  • Essentiale forte N;
  • Essential phospholipids;
  • The Essler.

Similar medicines:

Other medicines:
Reviews (30):
Guests
Semenova Marina
After 2 months of application of phosphoglue: high blood pressure, severe headache, hair loss (partial).
Guests
Natalia, 50 years old
Hello. In February 2013, he was treated for the first time (hepatitis C and already cirrhosis, complications). Treatment: fologogliv iv, glucose solution with Vitamin B, magnesium solution, omeprazole tablets, Mezim-Forte.
MINUS: with the first injection, a terrible headache, pain in the ears from any sound, temporary severe vision loss, external face change, detachment, thirst, edema, ascites, increased blood pressure.
PLUS: The level of transmemas is almost normal, a decrease in fibrosis.
By the way: All patients in my ward after injections lay gray-yellow with BP at 200.
Guests
eugene
I have been drinking phosphoglue for 4 years, sometimes I change tablets, it helps me a lot.
Guests
Andrei
At the reception of Phosphoglivan month, liver tests were normal.
Guests
Irina
Hepatitis C, high load. After the start of taking phosphoglue, a weakness has passed, this is incredibly pleasing, because only the beginning of the reception and I already feel the effect.Helps a lot! ALT and AST I plan to take 2 months after the course.
Guests
Seraphim
Treated Phosphoglivoy in 2013g. Before the treatment, the asat is almost normal - 52. After - 241. They began to eliminate the consequences of the treatment - they pricked heptral, it became a little better, but ... It's as bad as after taking Phosphogliv, I was never. And like and contraindications on the reception of this medicine are not any.
Guests
Tatyana
Hepatitis C, PCR - positive. Biochemistry is normal. Intravenous administration of phosphoglobin caused headache, fever, nasal congestion, severe coughing up to vomiting, loss of appetite, pain in the digestive tract and liver. And in the annotations on the boxes this drug is not noted, only here on the site I read about such side effects.
Guests
Gulnara
Buy Ufa production and everything will be fine. At you first nyxes, that is in / in it is necessary to do or make, then already tablets.
Guests
Tar
Phosphoglive I take during the meal, the last capsule I take when I go to bed. Two months have passed and I work for three.
Guests
Anton
Periodically, the pressure rises, but not critical. ALT was reduced from 300 to 90 and this gives a chance to wait for HTP. I have hepatitis C.
Visitors
soyka5959
Saw phosphoglue days 10. Pressure was raised to 182 at 95. Itself could not remove. We put magnesia. Although it is possible, the medicine is not to blame. Pressure last week rose to 135 and before it. The police officer said that the phosphoglue could not give it. But I now do not know whether to take it further when the pressure stabilizes?
Administrators
admin
soyka5959, Phosphogliv can just cause a rise in pressure and this is prescribed in the instructions for this drug. Another question is if the pressure rose above the norm before the drug was taken, then Phosphogliv was not to blame for the rise in blood pressure.
Guests
Alixey
Peal Phosphogliv for three days, got to the hospital with a sharp pain in his stomach, and the alt was normalized. I consulted with a doctor and told him not to drink again.
Guests
Natasha is 33 years old.
After two capsules: headache, stomach pain, nausea, general weakness (even heaviness) in the body.In a day I drank two more capsules, the same symptoms. She no longer ventured to take this medicine.
Guests
Stella
Have registered at a hepatitis With, for the first time a course in / in 10 on 5 ml, it is magnificent. From the first injection. No fatigue, there was activity, a good mood, I wanted to live. Surrendered after the course of blood for biochemistry and the result was pleased. Then I took the capsules orally, the effect is not the same. After three months again, the course was given an IV course, and again the activity after the first injection is amazing, incredible. Phosphoglivus returns me to normal active life. I will finish this course and of course I will donate blood for biochemistry, I'm sure the results will please.
Guests
NATALIA Becker
At me hr. cholecystitis. There were pains in the right hypochondrium periodically. Then they became permanent. The doctor prescribed phosphoglue. Here they write everything about the liver. Why then I was prescribed, if I have dyskinesia of the biliary tract. Is it somehow connected?
Administrators
admin
NATALIA BeckerMost likely, Phosphogliv has been assigned to you as a hepatoprotective agent for protecting liver cells in a slow process, this is sometimes used, but I do not,because there is no particular difference for the patient such an appointment with normal liver structure does not. It is better then to give drugs based on ursodeoxycholic acid (Ursosan, Ursofalk and others), they at least have a weak choleretic effect, which for your diagnoses can be useful.
Guests
Vyacheslav Dolgovykh
Few times had time to drink capsules. I had to call an ambulance. The pressure went off scale.
Guests
Vlad
A normal preparation. I drink already 3 months in occasion of excess reception of alcohol. Everything seems to be good, the tests are normal already, the liver also "lost weight" a little, as the doctor said after ultrasound.
Guests
Ilya Podgornov
Phosphoglivorous pleased. A quick effect (combined with Phosphogliva injections), a normal price, capsules can be bought without a prescription.
Guests
Anna_Maria
I liked Phosphogliv. Taken to the doctor's prescription from steatosis of the liver. There were AST and ALT at 90 U / L, and ultrasound also showed changes. For 3 months all the indicators of AST have come back to normal in the blood.On treatment spent the truth about 9 thousand rubles - did injections 10 times and then capsules saw.
Guests
Yana
Saw Fosfogliv - hepatic indices were very low. But besides that, I also kept the diet.
Guests
Lena
I am very glad that I have discovered such an effective tool, and it is especially pleasant that it is produced domestically.
Guests
lads
Can there be insomnia when taking Phosphogliva, pulling the vessels of the legs (especially at night), dry mouth?
Administrators
admin
lads, Adverse reaction to any medicine, can be varied, including individual, that is, not described in the instructions. If you clearly note the appearance of the negative symptoms indicated in the question with the use of Phosphogliv, my answer is yes.
Guests
Miroslava
The liver is a very vulnerable place in our body. Bad ecology in the capital, harmful food, smoking - it's all her not good. Therefore, I have long ago found myself a drug-hepatoprotector.Phosphogliv buy not just, and not with one doctor I consulted about him. I consider my choice to be correct, excellent tests that year speak for themselves.
Administrators
admin
Miroslava and the rest, I stand with your team of marketers a warning For advertising the drug Phosphogliv in reviews under the guise of ordinary visitors. Many pharmaceutical companies already know that similar methods of advertising in the Directory are considered unethical and are punished for the first time by a warning. If such an advertising campaign continues, the punishment will be tightened: the drug will be listed in the local blacklist, the moderation of the feedback will be significantly toughened, and all commentators noted by such customized reviews are banned without the possibility to leave their questions and comments on the site. Let's live amicably and no more hooligan.
Guests
lizz
Phosphogliv helped translate my perennial psoriatic headache into a remission phase. I hope, long :)
Guests
Igor Aksenov
Every year I pass a medical examination at work. I gave up biochemistry of blood, there they found high cholesterol and hepatic enzymes. They said with these tests to go to the local therapist at the polyclinic. There I was already assigned 3 months to take 2 capsules 3 times a day with Phosphogliv and completely change my lifestyle, i.e. less fried, salty, greasy, more to move. Now I walk every evening, although you will come home from work earlier - ate, looked at the TV on the couch and sleep :) For 2 months of taking the drug, the indicators almost came to normal, there is still a month to drink and control testing.
Guests
Stanislav
Hello. The doctor prescribed phosphoglue. Took 3 weeks, there was a turbidity in one eye, checked blood pressure 195 at 95 and was stupefied. Now I go to the doctors, burst in the eye of the vessel and try to stabilize the pressure. There was no hypertension and BP was normal.

Rules for publishing reviews and visitor questions