Kornam - instructions for use, reviews, analogs and formulations (2 mg and 5 mg tablets) of a medicament for the treatment of hypertension (pressure) in adults and in pregnancy

In this article, you can read the instructions for using the drug Kornam. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Kornam in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Kornam if there are existing structural analogues. Use for the treatment of hypertension and benign prostatic hyperplasia in adults, as well as in pregnancy and lactation.

Kornam - blocker of peripheral postsynaptic alpha 1-adrenergic receptors.

Blocking alpha 1-adrenergic receptors smooth muscle of the prostate and bladder neck, the drug contributes to the normalization of urination in patients with benign prostatic hyperplasia.

Causes the expansion of arterioles and venules, reduces OPSS and venous return to the heart, resulting in lowering blood pressure. The onset of hypotensive action 15 minutes after ingestion (single dose). The duration of antihypertensive action is 24 hours. The maximum effect when taking a single dose is achieved within 2-3 hours. The maximum hypotensive effect is achieved after 6-8 weeks of therapy. With prolonged use, a decrease in blood pressure is not accompanied, as a rule, by the development of reflex tachycardia.

The drug contributes to the normalization of lipid metabolism: reduces the cholesterol, TG, LDL and VLDL in the blood, while increasing the amount of HDL.

With the systematic application of Kornama, regression of left ventricular hypertrophy is noted.

Pharmacokinetics

After oral administration, it is quickly and completely absorbed from the digestive tract.Biotransformed in the liver with the formation of 4 metabolites, one of which (piperazine derivative of terazosin) has antihypertensive activity. It is excreted with bile (60%) and kidneys (40%, of which 10% - unchanged).

Indications

• benign prostatic hyperplasia (symptomatic treatment);
• arterial hypertension.

Forms of release

Tablets 2 mg and 5 mg.

Instructions for use and dosing regimen

With benign prostatic hyperplasia, the initial dose is 1 mg 1 time per day before bedtime. Gradually, the dose is increased to 2-10 mg per day until the optimal effect is achieved. Therapeutic effect is usually noted in 2 weeks from the start of treatment. To achieve a lasting effect, the course of treatment should be 4-6 weeks.

With arterial hypertension prescribe the drug in an initial dose of 1 mg per day before bedtime. Gradually, the dose is increased to achieve a clinical effect. The maintenance dose is 1-10 mg once a day. The maximum daily dose is 20 mg. In the event of a temporary discontinuation of the drug, treatment is resumed according to the same scheme.

Side effect

In the treatment of benign prostatic hyperplasia:

• orthostatic hypotension
• drowsiness
• dizziness
• asthenia
• nasal congestion.

In the treatment of hypertension:

• Orthostatic hypotension - the "first dose effect" (observed in 1% of patients who are predominantly receiving diuretics or beta-blockers at the same time), manifested by dizziness, tachycardia, syncope possible;
• heart palpitations
• peripheral edema
• nasal congestion.
• dizziness
• asthenia
• drowsiness
• impaired vision
• reduction (associated with hemodilution) of hematocrit, hemoglobin
• leukopenia
• hypoproteinemia
• hypoalbuminemia.
• decreased potency
• nausea.

Contraindications

• childhood;
• hypersensitivity to the drug.

Application in pregnancy and lactation

Korn can be used during pregnancy and during breastfeeding in the event that the potential benefit to the mother exceeds the possible risk to the fetus or baby.

special instructions

To prevent the development of orthostatic arterial hypotension treatment should begin with the appointment of Kornama at a dose of 1 mg per day at bedtime, after which the patient should be in bed 6-8 hours.

The risk of occurrence of orthostatic arterial hypotension (the "first dose effect") is highest during 30-90 min after taking the drug and is elevated in patients receiving beta-blockers and diuretics simultaneously, with a decrease in BCC, hypo-salt diet, and also with the resumption of treatment with the drug after break (several days).

In the event of a temporary cessation of treatment, the therapy is resumed with the same dose.

During treatment, the level of specific antigen of the prostate gland does not change. Before starting therapy for benign prostatic hyperplasia, prostate cancer should be excluded.

The patient should be informed of the increased risk of developing orthostatic hypotension with alcohol, prolonged standing or exercise, and in hot weather.

Impact on the ability to drive vehicles and manage mechanisms

Within 12 hours after taking the first dose, after increasing the dose or discontinuing therapy, it is not recommended to engage in potentially dangerous activities requiring increased attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of Kornam and beta-blockers, diuretics, calcium channel blockers, ACE inhibitors, the antihypertensive effect can be enhanced. Special caution is required when concomitant administration of terazosin and antihypertensive drugs are central.

Absorption of terazosin decreases with simultaneous intake of adsorbents and antacids.

Adrenomimetics weaken the effect of terazosin.

With the simultaneous use of terazosin and NSAIDs, it is possible to reduce antihypertensive effects due to suppression of prostaglandin synthesis and fluid retention and sodium ions.

Analogues of the drug Kornam

Structural analogs for the active substance:

• Setegis;
• Terazosin;
• Heitrin.

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