Actovegin - instructions for use, reviews, analogs and forms of release (tablets, injections in injections, ointment, gel and cream) drugs for the treatment of metabolic disorders of the brain in adults, children (newborns) and in pregnancy
In this article, you can read the instructions for using the drug Actovegin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Actovegin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Actovegin in the presence of existing structural analogues.Use for the treatment of metabolic and vascular disorders of the brain, trophism of tissues, burns and bedsores, diabetic polyneuropathy in adults, children (including newborns), as well as during pregnancy and lactation.
Actovegin - antihypoxant, is hemoderivat, which is obtained by dialysis and ultrafiltration (compounds with a molecular weight of less than 5,000 daltons penetrate).
Positively affects the transport and utilization of glucose, stimulates oxygen consumption (which leads to stabilization of plasma cell membranes in ischemia and a decrease in the formation of lactates) thus providing an antihypoxic effect.
Actovegin increases the concentrations of ATP, ADP, phosphocreatine, as well as amino acids (glutamate, aspartate) and GABA.
The effect of the drug Actovegin on the assimilation and utilization of oxygen, as well as insulin-like activity with the stimulation of transport and glucose oxidation, are significant in the treatment of diabetic polyneuropathy.
In patients with diabetes mellitus and diabetic polyneuropathy, Actovegin reliably reduces the symptoms of polyneuropathy (stitching, burning sensation, paresthesia, numbness of the lower limbs).Objective disorders are reduced sensitivity, mental well-being of patients improves.
The effect of Actovegin begins to manifest no later than 30 minutes (10-30 minutes) after parenteral administration and reaches a maximum, on average, after 3 hours (2-6 hours).
Composition
Deproteinized gemoderivat from calf blood (Actovegin concentrate or granulate) + auxiliary substances.
Pharmacokinetics
With the help of pharmacokinetic methods it is impossible to study the pharmacokinetic characteristics (absorption, distribution, excretion) of active components of the drug Actovegin, since it consists only of the physiological components that are usually present in the body.
To date, there has been no reduction in the pharmacological efficacy of hemoderivatives in patients with altered pharmacokinetics (including liver or renal insufficiency, metabolic changes associated with advanced age, due to metabolic peculiarities in newborns).
Indications
- metabolic and cerebral disorders of the brain (including ischemic stroke, craniocerebral injury);
- peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers);
- diabetic polyneuropathy;
- wound healing (ulcers of various etiologies, trophic disorders / bedsores /, burns, disturbance of wound healing processes);
- prevention and treatment of radiation injuries of the skin and mucous membranes with radiation therapy.
Forms of release
The tablets covered with a cover of 200 mg.
Solution for injections (injections) 40 mg / ml in ampoules of 5 ml and 10 ml.
Ointment for external use 5% (not supplied to Russia).
Cream for external use 5% (not supplied to Russia).
Gel for external use 20% (not supplied to Russia).
Instructions for use and dosage
Pills
Assign inside 1-2 tablets 3 times daily before meals. The tablet is not chewed, washed down with a small amount of water. Duration of treatment is 4-6 weeks.
Ampoules
The solution for injections is administered intraarterially, intravenously (including as an infusion or dropper) and intramuscularly. The infusion rate is about 2 ml / min. In connection with the potential for the development of anaphylactic reactions, it is recommended to test for hypersensitivity to the drug before the infusion.
The duration of the course of treatment is determined individually, depending on the symptomatology and severity of the disease.
Metabolic and cerebral disorders of the brain: from 5 to 25 ml (200-1000 mg per day) intravenously daily for two weeks, with the subsequent transition to a tablet form.
Ischemic stroke: 20-50 ml (800-2000 mg) in 200-300 ml of 0.9% solution of sodium chloride or 5% solution of dextrose, intravenously drip daily for 1 week, then 10-20 ml (400-800 mg ) intravenously drip - 2 weeks with the subsequent transition to the tablet form.
Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml (800 - 1000 mg) of the drug in 200 ml of 0.9% solution of sodium chloride or 5% solution of dextrose, intraarterially or intravenously daily; duration of treatment 4 weeks.
Diabetic polyneuropathy: 50 ml (2000 mg) per day intravenously for 3 weeks with the subsequent transition to the tablet form - 2-3 tablets 3 times a day for at least 4-5 months.
Wound healing: 10 ml (400 mg) intravenously or 5 ml intramuscularly daily or 3 to 4 times a week, depending on the healing process (in addition to local treatment with Actovegin in medicinal forms for external use).
Prevention and treatment of radiation lesions of the skin and mucous membranes with radiation therapy: the average dose is 5 ml (200 mg) intravenously daily in the interruption of radiation exposure.
Radiation cystitis: every day 10 ml (400 mg) is transurethral combined with antibiotic therapy.
Side effect
- skin rash;
- hyperemia of the skin;
- hyperthermia;
- hives;
- edema;
- drug fever;
- anaphylactic shock.
Contraindications
- Decompensated heart failure;
- pulmonary edema;
- oliguria, anuria;
- fluid retention in the body;
- hypersensitivity to the components of the drug;
- hypersensitivity to similar drugs.
Application in pregnancy and lactation
The use of the drug during pregnancy did not adversely affect the mother or fetus, however, if the drug is needed during pregnancy, the potential risk to the fetus should be taken into account. So the use of Actovegin in these cases requires caution.
special instructions
In connection with the potential for the development of anaphylactic reactions, it is recommended to perform a test (test injection of 2 ml IM) before the infusion.
In the case of intramuscular route of administration, the drug should be administered slowly in an amount not exceeding 5 ml.
Solutions of Actovegin have a slightly yellowish tinge. The color intensity can vary from one batch to another, depending on the nature of the raw materials used, but this does not affect the efficacy and tolerability of the preparation.
Do not use an opaque solution or solution containing particles.
With multiple administrations, the water-electrolyte balance of the blood plasma should be monitored.
After opening the ampoule or vial, the solution should not be stored.
Drug Interactions
Drug interaction of the drug Actovegin is not established.
However, to avoid possible pharmaceutical incompatibility, it is not recommended to add other medications to the infusion solution of Actovegin.
Analogues of the drug Actovegin
Actovegin does not have structural analogs for the active substance.
Analogues for the pharmacological group (antihypoxants and antioxidants):
- Actovegin granules;
- Actovegin concentrate;
- Antisthenes;
- Astrox;
- Vixipine;
- Vitanam;
- Hypoxen;
- Glathion;
- Deprenorm;
- Dihydroquercetin;
- Dimephosphone;
- Cardiocipine;
- Carditrim;
- Carnitine;
- Carniffite;
- Kudevita;
- Qudesan;
- Kudesan for children;
- Kudesan Forte;
- Levocarnitine;
- Limonar;
- Mexidant;
- Mexidol;
- Mexidol injection 5%;
- Mexicor;
- Mexipridol;
- Mexiprim;
- Mexicin;
- Methyl ethylpyridinol;
- Metostabil;
- Sodium oxybutyrate;
- Neurox;
- Neurolephone;
- Octolipen;
- Oliphen;
- Predizin;
- Preductal;
- Rexod;
- Romekor;
- Solcoseryl;
- Tiogamma;
- Tiotriazolin;
- Trekrezan;
- Tridoukard;
- Trimectal;
- Trimetazidine;
- Phenosanic acid;
- Cerekard;
- Cytochrome C;
- Eltacin;
- Emoxibel;
- Emoxipine;
- Energet;
- Yantavit.
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