Eutirox - instructions for use, analogs, reviews and release forms (tablets 25 mcg, 50 mcg, 75 mcg, 100 mcg, 125 mcg and 150 mcg) of the hormone drug for the treatment of hypothyroidism and goiter in adults, children and pregnancy. Composition and alcohol

In this article you can get acquainted with the instructions for the use of a hormonal drug Eutiroks. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Eutirox in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Eutirox with available structural analogues. Use for the treatment of hypothyroidism and goiter in adults, children,as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Eutiroks - a preparation of hormones of a thyroid gland. Synthetic levorotatory isomer of thyroxine. After partial conversion into triiodothyronine (in the liver and kidneys) and transition into the cells of the body, it affects the development and growth of tissues, metabolism. In small doses, it has an anabolic effect on protein and fat metabolism. In medium doses stimulates growth and development, raises the need for tissues in oxygen, stimulates the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and the central nervous system. In large doses, it inhibits the production of thyrotropin-releasing hormone of the hypothalamus and thyroid-stimulating hormone of the pituitary gland.

The therapeutic effect of Eutirox is observed after 7-12 days, during the same time the effect remains after the drug is discontinued. The clinical effect with hypothyroidism manifests itself in 3-5 days. Diffuse goiter decreases or disappears within 3-6 months.

Composition

Levotiroksin sodium + auxiliary substances.

Pharmacokinetics

When administered, Eutirox is absorbed almost exclusively in the upper part of the small intestine. Absorbed up to 80% of the dose of the drug.Eating lowers the absorption of levothyroxine. More than 99% of the absorbed drug binds to serum proteins (thyroxin-binding globulin, thyroxine-binding prealbumin and albumin). Thyroid hormones are metabolized mainly in the liver, kidneys, brain and muscles. A small amount of the drug is subjected to deamination and decarboxylation, as well as conjugation with sulfuric and glucuronic acids (in the liver). Metabolites are excreted in urine and bile.

Indications

• euthyroid goiter;
• hypothyroidism;
• after resection of the thyroid gland as a replacement therapy and for the prevention of recurrent goiter;
• thyroid cancer (after surgical treatment);
• diffuse toxic goiter after reaching the euthyroid status with thyreostatics (as a combination therapy or monotherapy);
• as a diagnostic tool in the test of thyroid suppression.

Forms of release

Tablets 25 μg, 50 μg, 75 μg, 100 μg, 125 μg and 150 μg.

Instructions for use and dosage

The daily dose is determined individually depending on the indications.

Eutirox in a daily dose is taken orally in the morning on an empty stomach, at least 30 minutes before a meal,with a small amount of liquid (half a glass of water) and without chewing.

When performing substitution treatment for hypothyroidism in patients under 55 years of age in the absence of cardiovascular diseases, Eutirox is prescribed in a daily dose of 1.6-1.8 μg / kg of body weight; in patients older than 55 years or with concomitant cardiovascular diseases - 0.9 μg / kg body weight.

With significant obesity, the calculation of the dose should be made on "ideal weight".

With substitution therapy for hypothyroidism, the initial dose for patients under 55 years of age (in the absence of cardiovascular diseases) is 75-100 micrograms per day for women, 100-150 micrograms per day for men. For patients over 55 years of age or with concomitant cardiovascular diseases, the initial dose is 25 μg per day; increase the dose should be at 25 mcg with an interval of 2 months to normalize the level of TSH in the blood; with the appearance or worsening of symptoms from the cardiovascular system, correct the appropriate therapy.

In severe long-term hypothyroidism, treatment should be started with extreme caution from small doses of 12.5 μg per day.The dose is increased to the supporting one at longer intervals - by 12.5 μg per day every 2 weeks - and the level of TSH in the blood is more often determined.

In the treatment of congenital hypothyroidism in children, the dose of the drug depends on the age:

• 0-6 months - daily dose of 25-50 μg - 10-15 μg / kg;
• 6-12 months - daily dose of 50-75 mcg - 6-8 mcg / kg;
• 1-5 years - a daily dose of 75-100 mcg - 5-6 mcg / kg;
• 6-12 years - daily dose of 100-150 mcg - 4-5 mcg / kg;
• over 12 years - a daily dose of 100-200 mcg - 2-3 mcg / kg.

Breast children a daily dose Eutirox give in 1 reception for 30 minutes before the first feeding. The tablet is dissolved in water to a fine suspension immediately before taking the drug.

In the treatment of euthyroid goiter, 75-200 μg per day is prescribed.

For the prevention of recurrence after surgical treatment of euthyroid goiter - 75-200 mcg per day.

In the complex therapy of thyrotoxicosis - 50-100 mcg per day.

For suppressive thyroid cancer - 50-300 mcg per day

With hypothyroidism, Eutirox is taken, as a rule, throughout life. In thyrotoxicosis, Eutirox is used in complex therapy with thyreostatics after reaching the euthyroid status. In all cases, the duration of treatment with the drug is determined individually.

Side effect

• allergic reactions.

Contraindications

• untreated thyrotoxicosis;
• untreated pituitary insufficiency;
• untreated insufficiency of the adrenal cortex;
• acute myocardial infarction;
• acute myocarditis;
• acute pancarditis;
• increased individual sensitivity to the drug.

Application in pregnancy and lactation

During pregnancy and during breastfeeding, therapy with a drug prescribed for hypothyroidism should continue. In pregnancy, an increase in the dose of the drug is required due to an increase in the level of thyroxine-binding globulin. The amount of thyroid hormone, secreted in breast milk during lactation (even during treatment with high doses of the drug), not enough to cause any disturbances in the child.

Application in pregnancy of the drug in combination with thyreostatics is contraindicated, because. taking levothyroxine may require increasing thyroid dose. Since thyreostatics, in contrast to levothyroxine, can penetrate the placenta, the fetus may develop hypothyroidism.

During breastfeeding, the drug should be taken with caution, strictly at recommended doses under the supervision of a doctor.

special instructions

When hypothyroidism, due to the pituitary lesion, it is necessary to find out whether there is a simultaneous insufficiency of the adrenal cortex. In this case, glucocorticoid replacement therapy should be started before the beginning of hypothyroidism treatment with thyroid hormones in order to avoid the development of acute adrenal insufficiency.

Impact on the ability to drive vehicles and manage mechanisms

The drug does not affect the professional activities associated with driving vehicles and controlling mechanisms.

Drug Interactions

Eutirox enhances the effect of indirect anticoagulants, which may require a reduction in their dose.

The use of tricyclic antidepressants with levothyroxine may lead to an increase in the action of antidepressants.

Thyroid hormones can increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose levels is recommended during the start of treatment with levothyroxine, as well as when changing the dose of the drug.

Levothyroxine reduces the action of cardiac glycosides.

With simultaneous application of colestyramine, colestipol and aluminum hydroxide reduce the plasma concentration of Eutirox by inhibiting its absorption in the intestine. In this regard, levothyroxine should be used 4-5 hours before taking these drugs.

When used simultaneously with anabolic steroids, asparaginase, tamoxifen, pharmacokinetic interaction at the level of binding to the protein is possible.

When used simultaneously with phenytoin, dicumarol, salicylates, clofibrate, Furosemide in high doses, the content of levothyroxine, which is not bound to proteins, increases.

Admission of estrogen-containing drugs increases the content of thyroxine-binding globulin, which may increase the need for Eutirox in some patients.

The drug is a natural hormone of the thyroid gland, so the use of alcohol together with Eutiroxom lies only in the plane of individual preferences of the individual.

Somatotropin with simultaneous application with levothyroxine may accelerate the closure of epiphyseal growth zones.

The intake of phenobarbital, Carbamazepine and rifampicin may increase the clearance of levothyroxine and require an increase in the dose.

Analogues of the drug Eutiroks

Structural analogs for the active substance:

• L-thyroxine (l thyroxine);
• Bagotiroks;
• L-Tirok;
• Levotiroksin sodium;
• Sodium levothyroxine;
• Tiro-4.

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