Nolitsin - instructions for use, reviews, analogs and forms of release (tablets 400 mg) of a drug for the treatment of cystitis and urethritis in adults, children and pregnancy. Composition and interaction of antibiotic with alcohol

In this article, you can read the instructions for using the drug Nolitsin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of antibiotic Nolitsin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nolicin in the presence of existing structural analogues. Use for the treatment of cystitis, urethritis, pyelonephritis in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Nolitsin - antimicrobial agent of a group of fluoroquinolones of a wide spectrum of action.

Has a bactericidal effect. The bacterial DNA enzyme acts on the bacterial enzyme, which ensures super-convoliation and, thus, the stability of bacterial DNA. The destabilization of the DNA chain leads to the death of bacteria. Has a wide range of antibacterial action.

Staphylococcus aureus (including strains of Staphylococcus spp., Resistant to methicillin), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp., Enterobacter spp., Hafhia alvei, Proteus spp. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp., Yersinia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp., Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp., Legionella spp.

Different sensitivity to the drug has: Enterococcus faecalis, Streptococcus spp. (Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum.

The duration of antimicrobial action is about 12 hours.

Composition

Norfloxacin + excipients.

Pharmacokinetics

After ingestion, Nolycin quickly, but not completely (20-40%) is absorbed from the digestive tract. Eating slows the absorption of the drug. It penetrates well into organs and tissues (kidney parenchyma, ovaries, seminal tubular fluid, prostate gland, uterus, abdominal and pelvic organs, bile, mother's milk).Penetrates through the blood-brain barrier (GEB) and the placental barrier. It is metabolized to an insignificant degree in the liver. It is excreted by the kidneys, by glomerular filtration and tubular secretion.

Indications

Infectious-inflammatory diseases caused by pathogens sensitive to the drug:

• acute and chronic infectious diseases of the urinary tract (urethritis, cystitis, pyelonephritis);
• infection of the genital organs (cervicitis, endometritis, chronic bacterial prostatitis);
• gonorrhea uncomplicated;
• bacterial gastroenteritis (salmonellosis, shigellosis);
• prevention of recurrence of urinary tract infections;
• prevention of sepsis in patients with neutropenia;
• prevention of travelers' diarrhea.

Forms of release

The tablets covered with a cover of 400 mg.

Instructions for use and dosing regimen

Inside, on an empty stomach (not less than 1 hour before or 2 hours after eating) and drink plenty of liquid.

The recommended dose is 400 mg twice a day. Duration of treatment is from 7 to 14 days, if necessary, spend a longer treatment.

With chronic bacterial prostatitis - 400 mg 2 times a day. for 4-6 weeks or more.

With uncomplicated gonorrhea - once in a dose of 800-1200 mg or 400 mg 2 times a day for 3-7 days.

In bacterial gastroenteritis (shigellosis, salmonellosis) - 400 mg 2 times a day for 5 days.

To prevent travel diarrhea, it is recommended to take 400 mg per day 1 day before departure, during the entire travel time and 2 days after the end (not more than 21 days).

For the prevention of sepsis with neutropenia - 400 mg 2 times a day for 8 weeks.

In acute uncomplicated cystitis - 400 mg 2 times a day for 3-5 days.

For the prevention of recurrent uncomplicated urinary tract infections with frequent exacerbations (more than 3 episodes a year or more than 2 in the course of six months) - 200 mg once a night for a long time (from 6 months to several years).

Side effect

• decreased appetite;
• bitter taste in the mouth;
• nausea, vomiting;
• abdominal pain;
• diarrhea;
• pseudomembranous enterocolitis (with prolonged use);
• glomerulonephritis;
• polyuria;
• urethral bleeding;
• increased urea and creatinine of blood plasma;
• headache;
• dizziness;
• fainting;
• insomnia;
• hallucinations;
• fatigue;
• drowsiness;
• anxiety;
• irritability;
• feeling of fear;
• depression;
• noise in ears;
• tachycardia;
• arrhythmias;
• a decrease in blood pressure;
• vasculitis;
• tendon ruptures (usually in the case of a combination with contributing factors);
• eosinophilia, leukopenia, reduction of hematocrit;
• rash;
• itching;
• hives;
• edema;
• malignant exudative erythema (Stevens-Johnson syndrome);
• candidiasis.

Contraindications

• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• lactation (breastfeeding);
• children and adolescents under 18;
• increased sensitivity to norfloxacin and other drugs of the group of fluoroquinolones.

Application in pregnancy and lactation

Safety of use during pregnancy and lactation (breastfeeding) has not been studied.

Prescribe Nolycin during pregnancy should only be for life indications, when the intended benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

special instructions

During the treatment, Nolitocinabols should receive a sufficient amount of fluid (under the control of diuresis).

During the period of therapy, an increase in the prothrombin index is possible (during surgical interventions it is necessary to monitor the state of the blood coagulation system).

During treatment with norfloxacin, exposure to direct sunlight should be avoided.

When pain occurs in the tendons or at the first signs of tendovaginitis, it is necessary to cancel the drug. During therapy with Norfloxacin it is recommended to avoid excessive physical exertion.

In the presence of an allergic reaction to acetylsalicylic acid, the azo dye E 110 (dye yellow dispenser, E110) can cause a hypersensitivity reaction, up to the bronchospasm.

Impact on the ability to drive vehicles and manage mechanisms

Care must be taken when driving a car and engaging in other potentially dangerous activities that require increased attention and speed of psychomotor reactions (especially when ethanol (alcohol) is used simultaneously).

Drug Interactions

With the simultaneous use of Nolycin and theophylline, the concentration of theophylline in the blood plasma should be monitored and its dose adjusted.norfloxacin reduces the clearance of theophylline by 25%, and the development of corresponding undesirable side effects can occur.

Nolitsin reduces the effect of nitrofurans.

Norfloxacin can enhance the therapeutic effects of cyclosporine and warfarin, in some cases, with the use of norfloxacin with cyclosporine, an increase in the serum creatinine concentration was observed, therefore, in such patients monitoring of this parameter is necessary.

The simultaneous use of norfloxacin and antacid agents containing aluminum or magnesium hydroxide, as well as preparations containing iron, zinc, sucralfate, reduces the absorption of norfloxacin (the interval between their intake should be at least 2 hours).

Simultaneous use with drugs that reduce the convulsive threshold can lead to the development of epileptiform seizures.

Simultaneous use with glucocorticosteroids (GCS) may increase the risk of tendonitis or cases of rupture of tendons.

Nolitsin can enhance the therapeutic effect of hypoglycemic drugs (derivatives of sulfonylureas).

Simultaneous reception of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp decrease in it. In this regard, in such cases, as well as with simultaneous administration with barbiturates and other drugs for general anesthesia, it is necessary to monitor heart rate, blood pressure and ECG parameters.

Analogues of the drug Nolitsin

Structural analogs for the active substance:

• Lokson-400;
• Norbaktin;
• Norillet;
• Normax;
• Noroksin;
• Norfacin;
• Norfloxacin;
• Renor;
• Sofazine;
• Chibroxin;
• Utibid.

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