Norbaktin - instructions for use, reviews, antibiotic analogues and formulations (400 mg tablets) of a drug for the treatment of cystitis, pyelonephritis and urethritis in adults, children and pregnancy. Interaction with alcohol

In this article, you can read the instructions for using the drug Norbaktin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Norbaktin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Norbaktin analogs in the presence of existing structural analogs. Use for the treatment of cystitis, pyelonephritis and urethritis in adults, children, as well as during pregnancy and lactation.Interaction of antibiotic with alcohol.

Norbaktin - antimicrobial synthetic agent of a group of fluoroquinolones of a wide spectrum of action. Has a bactericidal effect. Suppressing the DNA-gyrase, violates the process of supercoiling of DNA.

Highly active against most Gram-negative bacteria: Escherichia coli (E. coli), Salmonella spp. (salmonella), Shigella spp. (Shigella), Proteus spp. (Proteus), Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis.

It is active against some Gram-positive bacteria (including Staphylococcus aureus).

To Norfloxacin resistant anaerobic bacteria are resistant, low-sensitivity Enterococcus spp. and Acinetobacter spp.

Resistant to the action of beta-lactamases.

Composition

Norfloxacin + excipients.

Pharmacokinetics

When ingested absorbed about 30-40%, eating reduces the absorption rate. Binding to plasma proteins is 14%. Norfloxacin is well distributed in the tissues of the urogenital system. Penetrates through the placental barrier. About 30% is excreted unchanged in urine.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to norfloxacin.

For oral administration:

• diseases of the urinary tract, prostate, GIT;
• gonorrhea;
• prevention of recurrence of urinary tract infections, bacterial infections in patients with granulocytopenia, travelers' diarrhea.

For topical application:

• conjunctivitis;
• keratitis;
• keratoconjunctivitis;
• corneal ulcers;
• blepharitis;
• blepharoconjunctivitis;
• acute inflammation of the meibomian glands and dacryocystitis;
• prevention of eye infections after removal of a foreign body from the cornea or conjunctiva, after damage by chemical agents, before and after surgical interventions on the eyes;
• otitis externa;
• acute otitis media;
• chronic otitis media;
• prevention of infectious complications in surgical interventions on the hearing organ.

Forms of release

The tablets covered with a cover of 400 mg.

Instructions for use and dosing regimen

Inside, on an empty stomach (not less than 1 hour before or 2 hours after eating), squeezed with enough liquid.

In acute uncomplicated cystitis appoint 200-400 mg 2 times a day for 3-5 days.

In acute infections of the urinary tract - 400 mg 2 times a day for 7-10 days.

With recurrent or chronic recurrent urinary tract infections - 400 mg twice a day for 4 weeks and 400 mg per day for up to 12 weeks in case of a relapse.

For genital infections, 400-600 mg twice a day for 7 days.

In acute uncomplicated gonococcal infection - 800 mg once.

For the prevention of sepsis in patients with neutropenia - 400 mg 3 times a day for 8 weeks.

With infections of the gastrointestinal tract - 400 mg 2 times a day for 3-5 days.

To prevent bacterial diarrhea in epidemically unfavorable areas - 400 mg once a day.

In patients with impaired renal function with Cl creatinine more than 20 ml / min, correction of the dosing regimen is not required. With Cl creatinine below 20 ml / min (or a serum creatinine level of more than 5 mg / 100 ml) and patients on hemodialysis, 1/2 of the therapeutic dose 2 times a day or a full dose once a day is prescribed.

Side effect

• nausea;
• heartburn;
• anorexia;
• diarrhea;
• stomach ache;
• headache;
• dizziness;
• feeling tired;
• sleep disorders;
• irritability;
• sense of anxiety;
• skin rash;
• itching;
• angioedema;
• interstitial nephritis.

Contraindications

• pregnancy;
• lactation (breastfeeding);
• children and adolescence (up to 15 years);
• deficiency of glucose-6-phosphate dehydrogenase;
• increased sensitivity to norfloxacin and other preparations of the quinolone series.

Application in pregnancy and lactation

Norbaktin is contraindicated in pregnancy and lactation (breastfeeding), because in experimental studies it is established that it causes arthropathy.

Use in children

Contraindicated in children and adolescents under the age of 15 years.

special instructions

It should be used with caution in patients with epilepsy, convulsive syndrome of another etiology, with severe impairment of kidney and liver function. During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).

Norfloxacin should be taken at least 2 hours before or 2 hours after ingestion of antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate.

Simultaneous reception of Norbaktin and alcohol is prohibited.

Drug Interactions

With the simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.

With the simultaneous use of norfloxacin with cyclosporine, there is an increase in the concentration of the latter in the blood plasma.

With the simultaneous administration of Norbaktin and antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate,decreases the absorption of norfloxacin due to the formation of complexons with metal ions (the interval between their intake should be at least 4 hours).

With the simultaneous administration of norfloxacin reduces the clearance of theophylline by 25%, so with simultaneous use should reduce the dose of theophylline.

Simultaneous administration of Norbaktin with drugs that have the potential to reduce blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, it is necessary to monitor heart rate, blood pressure, ECG parameters. Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

Reduces the effect of nitrofurans.

Analogues of the drug Norbaktin

Structural analogs for the active substance:

• Loxon 400;
• Nolycin;
• Norillet;
• Normax;
• Noroksin;
• Norfacin;
• Norfloxacin;
• Renor;
• Sofazine;
• Chibroxin;
• Utibid.

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