Neo Penotran - instructions for use, reviews, analogs and forms of release (vaginal suppositories No. 7, Forte L) drugs for the treatment of vaginitis and candidiasis in women, including during pregnancy, lactation and menstruation. Interaction with alcohol

In this article, you can read the instructions for using the drug Neo Pentotran. There are reviews of visitors to the site - consumers of this medication, as well as the opinions of doctors specialists on the use of Neo Penotran in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Neo Penotran in the presence of existing structural analogs. Use for the treatment of vaginitis and candidiasis in women, including during pregnancy, lactation and menstruation.Interaction of the drug with alcohol.

Neo Pentotran - a combined preparation for intravaginal application with antifungal, antiprotozoal and antibacterial action.

Miconazole nitrate is an antifungal agent, an imidazole derivative. It is active against most fungi of Candida spp., Aspergillus spp., Dimorphons fungi, Criptococcus neoformans, Pityrosporum spp., Torulopsis glabrata, and also the relation of some Gram-positive microorganisms.

Metronidazole is an antimicrobial and antiprotozoal agent. It is active against Trichomonas vaginalis, Gardnerella vaginalis.

Candles Neo-Pentotran Forte-L contain miconazole, which has an antifungal effect, metronidazole, which has antibacterial and anti-trichomonoadic effects, as well as lidocaine, which gives a local anesthetic effect.

Lidocaine stabilizes the neuronal membrane, inhibiting the ion flows necessary for the generation and carrying out of impulses, thereby providing local anesthetic action.

Pharmacokinetics

With intravaginal application of miconazole, nitrate is absorbed insignificantly (approximately 1.4% of the dose). Bioavailability of Metronidazole for intravaginal application is 20% compared with oral intake.About 20% of the dose is excreted unchanged in the urine.

Indications

Local treatment:

• vaginal candidiasis;
• trichomonas vulvovaginitis;
• bacterial vaginosis (also caused by nonspecific vaginitis, anaerobic vaginosis, or gardnerellosis vaginitis);
• mixed vaginal infection.

Forms of release

Candles are vaginal.

Candles vaginal Neo Pentoran Forte.

Candles vaginal Neo Pentotran Forte L (with lidocaine).

Instructions for use and how to use them

The drug is prescribed for 1 vaginal suppository at night and 1 vaginal suppository in the morning for 7 days.

For recurrent vaginitis or vaginitis, resistant to previous therapy, 1 vaginal suppository is prescribed for the night and 1 vaginal suppository in the morning for 14 days.

Candles should be injected deep into the vagina with disposable fingertips contained in the package.

When prescribing the drug, elderly patients (over 65 years of age) do not need to change the dosage regimen.

Neo Penotran Forte L

If the doctor does not recommend otherwise, 1 candle is injected deep into the vagina at night for 7 days.

With relapsing disease or vaginitis, resistant to other treatment, it is recommended to extend the course of treatment to 14 days.

Suppositories should be administered in the supine position deep in the vagina with the help of attached disposable fingertips.

Side effect

• burning;
• itching;
• irritation of the vaginal mucosa (2-6%) (due to inflammation of the vaginal mucosa with vaginitis, irritation may worsen after the administration of the first suppository or on the third day of treatment.) These complications quickly disappear after discontinuation of treatment.
• abdominal cramping pain (3%);
• metallic taste in the mouth (1.7%);
• dry mouth;
• constipation;
• diarrhea;
• loss of appetite;
• nausea, vomiting;
• headache;
• dizziness;
• convulsions;
• skin rash;
• hives;
• leukopenia.

Contraindications

• severe violations of the liver (including porphyria);
• diseases of the peripheral nervous system and CNS;
• violations of hemopoiesis;
• 1 trimester of pregnancy;
• patients under the age of 14;
• virginity;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The appointment of Neo Penotran is contraindicated in the first trimester of pregnancy. In 2 and 3 trimester of pregnancy the use of Neo-Pentotrans is possible only in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

If it is necessary to prescribe Neo-Pentotrans during lactation, breastfeeding should be discontinued. Metronidazole is excreted in breast milk. Breastfeeding can be resumed 24-48 hours after the end of treatment.

special instructions

Possible influence of metronidazole on the activity of liver enzymes in the blood, as well as on the level of glycemia in determining the glucose content in the blood with the hexokinase method.

In the case of trichomoniasis, simultaneous treatment of the sexual partner is advisable.

With the simultaneous use of Neo-Penotran and the contraceptive diaphragm or condom, the interaction of the base of the vaginal suppository with the rubber is possible.

Drug Interactions

With the simultaneous use of Neo Penotran with ethanol (alcohol), disulfiram-like reactions occur.

With the simultaneous use of metronidazole with disulfiram, there may be abnormalities from the CNS (mental reactions).

With the simultaneous use of metronidazole increases the effect of indirect anticoagulants.

With simultaneous use with lithium preparations, an increase in lithium toxicity can be observed.

With the simultaneous use of Neo Penotran with phenytoin, the level of phenytoin in the blood increases, and the level of metronidazole in the blood decreases.

Phenobarbital with simultaneous application reduces the level of metronidazole in the blood.

With simultaneous use with cimetidine, the level of metronidazole in the blood can increase and, consequently, the risk of neurological side effects increases.

Metronidazole and miconazole inhibit the metabolism of astemizole and terfenadine, as a result of which the concentration of astemizole and terfenadine in the blood plasma increases.

It is possible to change the concentration of theophylline and procainamide in blood plasma when used simultaneously with Neo-Pentoran.

Analogues of the drug Neo Pentotran

Structural analogs for the active substance:

• Klion-D 100;
• Metromicon-Neo;
• Neo-Pentoran Forte.

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