Aponil - instructions for use, reviews, analogs and formulations (100 mg tablets) for the treatment of inflammation, fever and pain in adults, children and pregnancy based on Nimesulid

In this article, you can read the instructions for using the drug Aponil. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Aponila in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Aponil in the presence of existing structural analogues. Use to treat inflammation, fever and pain in adults, children, as well as during pregnancy and lactation.

Aponil - Non-steroidal anti-inflammatory drug. Selective cyclooxygenase-2 inhibitor (COX-2). The drug has an anti-inflammatory, analgesic and antipyretic effect, the mechanism of which is due to selective inhibition of COX-2, which leads to a decrease in the synthesis of prostaglandins in the focus of inflammation, as well as in the hypothalamus. The effect on the synthesis of prostaglandins in the mucous membrane of the stomach and kidneys is much less pronounced, which causes a good tolerance of nimesulide. The drug also inhibits lipid peroxidation and formation of free oxygen radicals, reduces the formation of platelet activation factor, tumor necrosis factor alpha, release of histamine, proteinases and some other mediators of inflammation.

Pharmacokinetics

After ingestion, Nimesulide (the active substance of the Aponil prepolite) is well absorbed from the digestive tract. The intake of food reduces the rate of absorption, without affecting its degree. Cumulation with prolonged use is not observed. Nimesulide is biotransformed in the liver to form an active (hydroxynimesulide - up to 25% dose) and several inactive metabolites. It is excreted in the urine (65-98% of the dose during the day) and with feces (up to 35% of the dose).

Indications

• pain syndrome of various genesis (including headache, toothache, algodismenorea, post-traumatic and post-operative pain);
• fever of various genesis (including acute respiratory viral infections and other infectious and inflammatory diseases);
• inflammatory diseases of the musculoskeletal system (arthritis, arthrosis, tendovaginitis, bursitis, myositis).

Forms of release

Tablets of 100 mg.

Instructions for use and dosing regimen

A single dose for adults is 50 to 200 mg, the average dose is 100 mg, the maximum daily dose is 400 mg.

Children over 12 years of age are prescribed a single dose at a dose of 1.5 mg / kg body weight (but not more than 100 mg); the maximum daily dose is 5 mg / kg.

The drug is taken 2 times a day after meals; the tablets are washed down with water.

Side effect

• pain in the epigastric region;
• ulceration of the mucosa of the gastrointestinal tract;
• diarrhea;
• heartburn;
• nausea, vomiting;
• headache;
• dizziness;
• drowsiness;
• hematuria (blood in the urine);
• edema;
• Thrombocytopenia, leukopenia, anemia, agranulocytosis;
• skin rash;
• hives;
• anaphylactic shock.

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation);
• gastrointestinal bleeding;
• aspirin asthma;
• severe violations of liver function;
• severe renal dysfunction (CC less than 30 ml / min);
• 3 trimester of pregnancy;
• lactation (breastfeeding);
• children's age till 12 years;
• increased sensitivity to nimesulide and other NSAIDs.

Application in pregnancy and lactation

The drug can be used in pregnancy only in those cases when the expected benefit for the mother exceeds the potential risk to the fetus.

It is not recommended to prescribe the drug during lactation. If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

In experimental studies, embryotoxic and teratogenic effects of the drug have not been established.

special instructions

Caution should be given to aponil in hypertension, heart failure and type 2 diabetes mellitus.

With caution and low doses, Aponil is prescribed for violations of kidney function, with a violation of liver function, peptic ulcer and duodenal ulcer in history, systemic lupus erythematosus, with the simultaneous use of diuretics, anticoagulants and in the elderly.

With the appointment of Aponila, patients with hypersensitivity to other non-steroidal anti-inflammatory drugs may develop allergic reactions.

Drug Interactions

With simultaneous use, nimesulide competes for binding to plasma proteins and increases the risk of side effects of sulfonylureas (including oral hypoglycemic agents), hydantoin, digitalis preparations, cyclosporine and methotrexate.

When combined with acetylsalicylic acid, nimesulide is displaced from the bond with blood plasma proteins, while the concentration of free nimesulide in plasma increases 2-3 times.

With the simultaneous use of nimesulide enhances the effect of indirect anticoagulants.

With simultaneous use with lithium preparations, nimesulide increases the concentration of lithium in blood plasma.

Analogues of the drug Aponil

Structural analogs for the active substance:

• Actasulide;
• Amoeolin;
• Aulin;
• Coxtral;
• Mesulide;
• Nyz;
• Nemux;
• Nimegesic;
• Nimesil;
• Nimesulide;
• Nimika;
• Nimulid;
• Novolide;
• Prolid;
• Sulaydine;
• Fllolid.

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