Naise - instructions for use, reviews, analogs and formulations (50 mg and 100 mg tablets, 1% gel, suspension or syrup) drugs for the treatment of pain and inflammation in joints and muscles in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Nyz. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Naise in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Naise's analogues in the presence of existing structural analogs. Use to treat pain and inflammation in joints and muscles in adults, children, as well as during pregnancy and lactation.
Nyz - Non-steroidal anti-inflammatory drug. Selective inhibitor of COX-2 - an enzyme involved in the synthesis of prostaglandins - mediators of edema, inflammation and pain. The drug has anti-inflammatory, analgesic and antipyretic effect.
Reversibly inhibits the formation of prostaglandin E2, both in the focus of inflammation, and in the ascending pathways of the nociceptive system, including the pathways of pain impulses in the spinal cord.
Reduces the concentration of short-lived prostaglandin H2, from which prostaglandin isomerase produces prostaglandin E2. A decrease in the concentration of prostaglandin E2 leads to a decrease in the degree of activation of prostanoid EP receptors, which is expressed in analgesic and anti-inflammatory effects.
Has little effect on COX-1, practically does not prevent the formation of prostaglandin E2 from arachidonic acid under physiological conditions, thereby reducing the side effects of the drug.
Nyz suppresses platelet aggregation by inhibiting the synthesis of endoperoxides and thromboxane A2, inhibiting the synthesis of the platelet aggregation factor.Suppresses the release of histamine, and also reduces the degree of bronchospasm caused by the action of histamine and acetaldehyde.
It has been shown that Nimesulide (Nise's active substance) is able to suppress the synthesis of interleukin-6 and urokinase, thereby preventing the destruction of cartilaginous tissue. Inhibits the synthesis of metalloproteases (elastase, collagenase), preventing the destruction of proteoglycans and cartilaginous collagen.
It has antioxidant properties, inhibits the formation of toxic products of oxygen decay due to a decrease in the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them by phosphorylation, which also enhances the anti-inflammatory effect of the drug.
When topical application causes weakening or disappearance of pain in the place of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Promotes an increase in the volume of movements.
Pharmacokinetics
After oral administration, Nyz is well absorbed from the digestive tract. The intake of food reduces the rate of absorption, without affecting its degree.Penetrates into the tissue of the female genital organs, where after a single intake the concentration of nimesulide is about 40% of the concentration in the plasma. It penetrates into the acidic environment of the inflammatory focus (40%), synovial fluid (43%). Easily penetrates through the histo-hematical barriers. Metabolite is excreted by the kidneys (65%) and with bile (35%).
Indications
- rheumatoid arthritis;
- articular syndrome with rheumatism and exacerbation of gout;
- psoriatic arthritis;
- ankylosing spondylitis;
- osteochondrosis with radicular syndrome;
- radiculitis;
- sciatica;
- lumbago;
- osteoarthritis;
- arthritis of various etiologies;
- arthralgia;
- myalgia of rheumatic and non-rheumatic origin;
- inflammation of ligaments, tendons, bursitis;
- postavmaticheskoe inflammation of soft tissues and the musculoskeletal system (injuries and ruptures of ligaments, bruises);
- pain syndrome of different genesis (including in the postoperative period, with trauma, algodismenorea, toothache, headache);
- fever of different genesis (including with infectious and inflammatory diseases).
Forms of release
Tablets of 100 mg.
Tablets are dispersible 50 mg (can be used to prepare a suspension or syrup, by dissolving in water,this form is convenient for use in childhood).
Gel for external use 1%.
Instructions for use and dosage
Pills
Inside, adults are prescribed 100 mg twice a day. The maximum daily dose is 400 mg.
The drug in the form of a suspension is preferable to take before meals, but if you feel discomfort in the stomach, you can take at the end or after eating.
The drug in the form of dispersible tablets should be taken at the end or after meals. Before taking 1 tablet, dissolve in 5 ml (1 teaspoon) of water.
For children over the age of 2, the drug is administered in the form of a suspension, for children over the age of 3 years - in the form of dispersible tablets or suspension, for children over 12 years of age, the drug can be given in the form of tablets (100 mg twice a day). The recommended dose is 3-5 mg / kg of body weight 2-3 times a day. The maximum dose is 5 mg / kg per day in 2-3 doses. To adolescents with a body weight of more than 40 kg, the drug is prescribed 100 mg twice a day.
The maximum dose is 5 mg / kg of body weight per day. The duration of the drug is 10 days.
Gel
Before applying the gel, you should wash and dry the surface of the skin. Uniform thin layer, without rubbing, apply a strip of gel length of approximately 3 cm to the area of maximum soreness 3-4 times a day.
The amount of gel and frequency of its use (no more than 4 times a day) varies depending on the size of the treated area of the skin and the patient's reaction.
The maximum dose is 5 mg / kg per day (30 g per day). Duration of the drug - no more than 10 days without consulting a doctor.
Side effect
- heartburn;
- nausea, vomiting;
- pain in the stomach;
- diarrhea;
- erosive and ulcerative lesions of the gastrointestinal tract;
- headache;
- dizziness;
- Thrombocytopenia, leukopenia, anemia, agranulocytosis;
- skin rash;
- anaphylactic shock;
- bronchospasm;
- fluid retention;
- prolonged bleeding time;
- hematuria (blood in the urine);
- when applying the gel - itching, hives, peeling, transient skin discoloration (does not require drug withdrawal).
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
- bleeding from the digestive tract;
- "aspirin triad";
- impaired liver function;
- severe renal failure (CK <30 mL / min);
- pregnancy;
- lactation (breastfeeding);
- dermatosis, epidermal damage, skin infection in the field of application (for gel);
- children under 2 years;
- increased sensitivity to nimesulide and other components of the drug, acetylsalicylic acid and other NSAIDs.
Application in pregnancy and lactation
Naiz is contraindicated in pregnancy.
If you need to use the drug during lactation, you should decide whether to stop breastfeeding.
special instructions
Caution should be given to Nase patients with impaired renal function, visual impairment.
With prolonged use, it is necessary to monitor the functions of the liver and kidneys.
When applying the drug in elderly patients, correction of the dosing regimen is not required.
Impact on the ability to drive vehicles and manage mechanisms
Due to the fact that Naise may cause dizziness and drowsiness during ingestion, the drug should be used with caution in patients who engage in potentially dangerous activities that require increased concentration of attention and rapid psychomotor reactions.
Drug Interactions
Possible manifestations of drug interactions (due to competing drugs for binding to proteins) with simultaneous ingestion of the drug Nyz with digoxin, phenytoin, lithium preparations, diuretics,antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, oral hypoglycemic agents.
Analogues of Naise
Structural analogs for the active substance:
- Actasulide;
- Amoeolin;
- Aponil;
- Aulin;
- Coxtral;
- Mesulide;
- Nemux;
- Nimegesic;
- Nimesil;
- Nimesulide;
- Nimesulide-Pharmaplant;
- Nimika;
- Nimulid;
- Novolide;
- Prolid;
- Sulaydine;
- Fllolid.
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