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Naise - instructions for use, reviews, analogs and formulations (50 mg and 100 mg tablets, 1% gel, suspension or syrup) drugs for the treatment of pain and inflammation in joints and muscles in adults, children and in pregnancy

Naise - instructions for use, reviews, analogs and formulations (50 mg and 100 mg tablets, 1% gel, suspension or syrup) drugs for the treatment of pain and inflammation in joints and muscles in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Nyz. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Naise in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Naise's analogues in the presence of existing structural analogs. Use to treat pain and inflammation in joints and muscles in adults, children, as well as during pregnancy and lactation.

 

Nyz - Non-steroidal anti-inflammatory drug. Selective inhibitor of COX-2 - an enzyme involved in the synthesis of prostaglandins - mediators of edema, inflammation and pain. The drug has anti-inflammatory, analgesic and antipyretic effect.

 

Reversibly inhibits the formation of prostaglandin E2, both in the focus of inflammation, and in the ascending pathways of the nociceptive system, including the pathways of pain impulses in the spinal cord.

 

Reduces the concentration of short-lived prostaglandin H2, from which prostaglandin isomerase produces prostaglandin E2. A decrease in the concentration of prostaglandin E2 leads to a decrease in the degree of activation of prostanoid EP receptors, which is expressed in analgesic and anti-inflammatory effects.

 

Has little effect on COX-1, practically does not prevent the formation of prostaglandin E2 from arachidonic acid under physiological conditions, thereby reducing the side effects of the drug.

 

Nyz suppresses platelet aggregation by inhibiting the synthesis of endoperoxides and thromboxane A2, inhibiting the synthesis of the platelet aggregation factor.Suppresses the release of histamine, and also reduces the degree of bronchospasm caused by the action of histamine and acetaldehyde.

 

It has been shown that Nimesulide (Nise's active substance) is able to suppress the synthesis of interleukin-6 and urokinase, thereby preventing the destruction of cartilaginous tissue. Inhibits the synthesis of metalloproteases (elastase, collagenase), preventing the destruction of proteoglycans and cartilaginous collagen.

 

It has antioxidant properties, inhibits the formation of toxic products of oxygen decay due to a decrease in the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them by phosphorylation, which also enhances the anti-inflammatory effect of the drug.

 

When topical application causes weakening or disappearance of pain in the place of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Promotes an increase in the volume of movements.

 

Pharmacokinetics

 

After oral administration, Nyz is well absorbed from the digestive tract. The intake of food reduces the rate of absorption, without affecting its degree.Penetrates into the tissue of the female genital organs, where after a single intake the concentration of nimesulide is about 40% of the concentration in the plasma. It penetrates into the acidic environment of the inflammatory focus (40%), synovial fluid (43%). Easily penetrates through the histo-hematical barriers. Metabolite is excreted by the kidneys (65%) and with bile (35%).

 

Indications

  • rheumatoid arthritis;
  • articular syndrome with rheumatism and exacerbation of gout;
  • psoriatic arthritis;
  • ankylosing spondylitis;
  • osteochondrosis with radicular syndrome;
  • radiculitis;
  • sciatica;
  • lumbago;
  • osteoarthritis;
  • arthritis of various etiologies;
  • arthralgia;
  • myalgia of rheumatic and non-rheumatic origin;
  • inflammation of ligaments, tendons, bursitis;
  • postavmaticheskoe inflammation of soft tissues and the musculoskeletal system (injuries and ruptures of ligaments, bruises);
  • pain syndrome of different genesis (including in the postoperative period, with trauma, algodismenorea, toothache, headache);
  • fever of different genesis (including with infectious and inflammatory diseases).

 

Forms of release

 

Tablets of 100 mg.

 

Tablets are dispersible 50 mg (can be used to prepare a suspension or syrup, by dissolving in water,this form is convenient for use in childhood).

 

Gel for external use 1%.

 

Instructions for use and dosage

 

Pills

 

Inside, adults are prescribed 100 mg twice a day. The maximum daily dose is 400 mg.

 

The drug in the form of a suspension is preferable to take before meals, but if you feel discomfort in the stomach, you can take at the end or after eating.

 

The drug in the form of dispersible tablets should be taken at the end or after meals. Before taking 1 tablet, dissolve in 5 ml (1 teaspoon) of water.

 

For children over the age of 2, the drug is administered in the form of a suspension, for children over the age of 3 years - in the form of dispersible tablets or suspension, for children over 12 years of age, the drug can be given in the form of tablets (100 mg twice a day). The recommended dose is 3-5 mg / kg of body weight 2-3 times a day. The maximum dose is 5 mg / kg per day in 2-3 doses. To adolescents with a body weight of more than 40 kg, the drug is prescribed 100 mg twice a day.

 

The maximum dose is 5 mg / kg of body weight per day. The duration of the drug is 10 days.

 

Gel

 

Before applying the gel, you should wash and dry the surface of the skin. Uniform thin layer, without rubbing, apply a strip of gel length of approximately 3 cm to the area of ​​maximum soreness 3-4 times a day.

 

The amount of gel and frequency of its use (no more than 4 times a day) varies depending on the size of the treated area of ​​the skin and the patient's reaction.

 

The maximum dose is 5 mg / kg per day (30 g per day). Duration of the drug - no more than 10 days without consulting a doctor.

 

Side effect

  • heartburn;
  • nausea, vomiting;
  • pain in the stomach;
  • diarrhea;
  • erosive and ulcerative lesions of the gastrointestinal tract;
  • headache;
  • dizziness;
  • Thrombocytopenia, leukopenia, anemia, agranulocytosis;
  • skin rash;
  • anaphylactic shock;
  • bronchospasm;
  • fluid retention;
  • prolonged bleeding time;
  • hematuria (blood in the urine);
  • when applying the gel - itching, hives, peeling, transient skin discoloration (does not require drug withdrawal).

 

Contraindications

  • erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
  • bleeding from the digestive tract;
  • "aspirin triad";
  • impaired liver function;
  • severe renal failure (CK <30 mL / min);
  • pregnancy;
  • lactation (breastfeeding);
  • dermatosis, epidermal damage, skin infection in the field of application (for gel);
  • children under 2 years;
  • increased sensitivity to nimesulide and other components of the drug, acetylsalicylic acid and other NSAIDs.

 

Application in pregnancy and lactation

 

Naiz is contraindicated in pregnancy.

 

If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

 

special instructions

 

Caution should be given to Nase patients with impaired renal function, visual impairment.

 

With prolonged use, it is necessary to monitor the functions of the liver and kidneys.

 

When applying the drug in elderly patients, correction of the dosing regimen is not required.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Due to the fact that Naise may cause dizziness and drowsiness during ingestion, the drug should be used with caution in patients who engage in potentially dangerous activities that require increased concentration of attention and rapid psychomotor reactions.

 

Drug Interactions

 

Possible manifestations of drug interactions (due to competing drugs for binding to proteins) with simultaneous ingestion of the drug Nyz with digoxin, phenytoin, lithium preparations, diuretics,antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, oral hypoglycemic agents.

 

Analogues of Naise

 

Structural analogs for the active substance:

  • Actasulide;
  • Amoeolin;
  • Aponil;
  • Aulin;
  • Coxtral;
  • Mesulide;
  • Nemux;
  • Nimegesic;
  • Nimesil;
  • Nimesulide;
  • Nimesulide-Pharmaplant;
  • Nimika;
  • Nimulid;
  • Novolide;
  • Prolid;
  • Sulaydine;
  • Fllolid.

Similar medicines:

Other medicines:

Reviews (37):
Guests
dad
I returned home from work one day and got off the bus (it was in winter) and fell on my outstretched hand. She began to get sick very badly and swelled up, and her hand and palm turned black. There was no fracture in the picture. Traumatologist advised to drink Nice and rub Ketonal gel into the blackened hand at the same time. What did help me out of this set-I do not know, but very quickly the blackness changed to yellowness,the swelling passed for a week, and then the yellowness was replaced by normal skin color, so it was without consequences. I trust less than oats and gels, so I decided that Nice helped.
Guests
Ivan
Good Nize gel. I was helped to get rid of back pain in three days. Previously I used Diclofenac and Voltaren, but since the problem is repeated often, I seriously planted my stomach - I had to use a remedy that does not affect the stomach much like diclofenacs. And this tool was Nyz. For three days I did not observe, no nausea, no burping, as it was before.
Guests
Nuria
And for me, Nize was ineffective, if not useless. I once had a neckache, I know for sure that it blew in the minibus. Mom slipped this package. She smeared conscientiously, long and hard for several days. The pain, as well as the terrible discomfort caused by it, have not gone anywhere. But ketonal well helped.
Guests
Lyudmila
Saw Naiz a week, there were terrible swelling. The doctor told me that it was necessary to immediately cancel this drug delays the water inorganism. About the gel Naiz generally no impressions, except for discarded money. I have polyarthritis and I am saved only by Nimesil. The only drawback is expensive!
Administrators
admin
Lyudmila, Nyz and Nimesil contain the same active substance - Nimesulide. This is one of those cases when the side reaction goes to additional components of the drugs that can cause a side reaction of the body, which happened in your case, Lyudmila. I also do not exclude the option of buying a fake, this also often happens in the Russian market.
Guests
Elena, 61 years old
Naiz used on the recommendation of her daughter. There were very severe pain in the lower part of the spine. I gave it all over my leg. It was not possible to get up from a prone and sitting position (in the anamnesis chronic osteochondrosis). After the first day of taking the drug (400 mg dose), the pain was completely gone. Of side effects: not a lot of diarrhea, a slight swelling of the right hand (but perhaps a big load on the arm and provoked pain). I do not know whether it is possible to take the drug all 10 days, as indicated in the recommendation, since I was 20 years ago had an ulcer DPC.
Administrators
admin
Elena, 61 years old, It is necessary to be careful with the ulcer, especially when the medicine is advised by relatives or friends (if your daughter, of course, is not a doctor). Theoretically, you can take, but at 61 I doubt that there are still no reasons for pain in the lower parts of the spine. If regular annual medical examinations do not pass - then go to the doctor and be examined for additional diseases and if everything is good, you can continue taking Naise.
Guests
prokopenko vitali
From a toothache helps.
Guests
uvarov alexander
Only naiz from a toothache, the rest is useless, I tried everything.
Guests
Igor T.
Is it possible to apply Nyz continuously? And what should be the intervals, if one pill per day helps? Will the effectiveness decrease?
Administrators
admin
Igor T.The standard course of treatment for Naise is a maximum of two weeks. More you can,but it is necessary to monitor the work of the organs involved in metabolism and excretion of the metabolic products of the drug from the body, and this is the liver and kidneys, since problems with these organs can occur with prolonged admission. If a particular drug can not work out normally within two weeks of treatment, then we are working on one of the links in the pathological process, not all possible ones, or trying to heal only the symptom, but not the cause of the disease.
Guests
Igor T.
After an operation on the ankle, arthritis developed. With the admission of "Naise", the pain disappeared, but a week later appeared again. To me 53 years, at loadings there is a point pain in a back, fatigability.
Guests
Vera
Excellent preparation, I have polyarthritis. It helps instantly, but the price has become 280 rubles. It's very expensive for me.
Visitors
d07071962
Whether it is possible to repeat course of treatment. How quickly Naise is excreted from the body? What is the effectiveness of treatment of arthrosis, arthritis of the lower extremities. Are there any stronger drugs for treatment?
Administrators
admin
d07071962, Yes, the course of treatment with Naise can be repeated if there are no contraindications and side effects when taking the medication. The half-life of Naise is about 5 hours, that is, during the day the organism is completely freed from the active substance. If a positive effect is achieved and taking the drug has led to the elimination of inflammation and pain in the joint syndrome, the therapeutic effect can be observed long enough. Efficacy for arthrosis and arthritis is high, unless other, more powerful anti-inflammatory drugs have been taken before. Stronger in this group of patients will be nonsteroidal anti-inflammatory drugs (NSAIDs), phenylacetic acid derivatives (Diclofenac and its analogs), propionic acid derivatives (ketoprofen and its analogs).
Visitors
d07071962
Many thanks for the detailed information.
Guests
Angela
Nyz very well helps with a toothache!
Guests
Chris
Fell, stretched ligaments in the knee. The doctor said to use Naise gel. After 5 days I noticed a rash on my knee and face. Has drunk tablets from an allergy, tk. I thought that the allergic reaction had begun. On the face there is not a trace. But the knee ... on the knee burn. It hurts badly, itches. I do not know how to smear it. sad
Visitors
ZIG
He pulled the ligaments on his ankle. Have registered najz gel. Mazal 2-3 days, the pain subsided. But there was a rash and itching all over the body. I do not smear gel for a week now. Rashes and itching do not go away. Tell me how to get rid of the rash and itching?
Administrators
admin
ZIGYou can take any antihistamine drug, like Loratadin (Claritin and other trademarks), Cetirizina (Zirtek and other brands). It is enough to take a couple of days. If the rash and itching pass and do not appear any more, then it's good, just remember about this reaction of your body to Naise gel and try to minimize its use in the future. If allergic manifestations do not decrease or reappear - it is worth to consult an allergist for advice, and possibly a dermatologist,because I can not look at the rash online and therefore differentiate these diagnoses too.
Guests
Danna
Has transferred a review to preparation Fastum gel where he is more pertinent.
admin
Guests
Gennady G.
Naise drank to the appointment of a surgeon after a bruise and sprained ligaments of his leg - there was a large swelling in the foot area and inflammation, the pain was such that every slightest movement gave directly to the head. He could not walk. What can I say about this drug - with him, firstly, the first week and a half just did not part, as soon as the effect was passing - pain returned, and with niaz could do something himself. Secondly, I was appointed by the doctor after the first drug with another active substance did not come up to me due to the fact that immediately started to muddle from him, and from Nais, as I was told, the safety profile for the stomach is better. So with him somehow he recovered - without him, I probably can not imagine how I could manage.
Guests
Madina
From the very first pill, Naise let go of the sciatic nerve, with the second, it's even easier.
Guests
Andrei
On Wednesday I put a seal on the wisdom tooth. And on Monday, pain began in this part of the jaw. At home, Naise, began to take. Helps the clock at 6, and you can only take 2 times 100 ml.
Guests
Olga
Sore throat, sore throat. I drank 1 tablet yesterday. It helped with a sore throat. Today I drank 1 tablet did not help, I drank another 30 minutes later, helped, but after 15 minutes I started feeling sick.
Guests
Marina Golubeva
She dragged the child in her arms during the excursion, the shoulder and the whole right side of the torso burned like fire. I drank a naize - it immediately became easier. On the trail. day has visited all the same a trauma - have told to continue to drink still couple of days. Which I did - and it all went like magic!
Guests
Irina
Naise I drink at any pain. It helps me well, even from varicose veins (when veins hurt), osteochondrosis, headaches, back, lumbar.
Guests
Irkutsk
For several years my back ached heavily in the lumbosacral section, was examined for a long time, was treated for a long time: massage, physiotherapy, movalis, tselebreks and so on.The pain continued. The son brought pill Nise. After reading the instructions, I took one tablet. Miracle! The back has ceased to hurt or be ill; be sick. One tablet was enough for 2 days. I drank 6 tablets in 12 days. I've been without treatment for two years in the hospital and do not take more pills from back pain, because it's not there. I myself am surprised.
Guests
I recommend Nise
Esteemed the reviews, already hooked, I see negative. Naise is a mega tablet. Of the minuses - a little nauseous the next day (but I have strong persistent problems with zhkt). From the plus - instantly removes the headache and pain from menstruation (other pills did not help at all). And with pain I take a quarter of a tablet or even 1/6 (so that less chemistry gets into the body). Cope within 20 minutes.
Guests
Kucherenko Maya Vladimirovna
Took Najz in connection with a pain in a knee joint, the pain was especially strong at descent on a ladder. It helped quickly. A month after that, I went to the mountains, at the first small pain symptoms began to drink 1 tab. in a day. Has helped or assisted, climbed on mountains of 5 days, with GASTROINTESTINAL TRACT all was by way of.
Guests
lads
Naise I accept for a long time since I have chronic diseases of the spine and coxarthrosis of the hip joint. He helps me well, 1 tablet lasts for 2 days. But it happens so that I take every day. But I'm working. If I take a break during the week, then severe pain begins, although I still take the Proenzi plus supplement, and I smear Voltaren emulsion 23.2 mg. Nize is a good drug, but I'm worried whether this drug will affect the human body from prolonged use. Since I know that there is such a drug Prednisolone, if it is taken for years, it destroys the internal tissues of the body.
Administrators
admin
ladsIt's not necessary to take Nyz regularly. Any anti-inflammatory drugs are prescribed according to the instructions and recommendations of the attending physician as little as possible. I see in your case rather the ineffectiveness of this remedy and it is worth treating the shortest course of a stronger anti-inflammatory drug, for example, based on Diclofenac. There are a lot of drugs on the market today, there are different actions and mechanisms. Consult your doctor.
Guests
Tatyana
Nimesulide through how much is excreted from the body? I on gv are, if milk to decant, that is to pass one or two feeding by a breast and to give a mix. Is it possible?
Administrators
admin
Tatyana, The half-life of nimesulide (the active substance of the drug Naise) from the body is 2-3 hours. It can be assumed that after 6 hours the body will be completely free of the active substance of the drug. But this is an ideal situation, individual characteristics of the organism, concomitant diseases and conditions that can potentially prolong the period of drug excretion can still interfere here.
Guests
Tatyana
Perfectly helps. I drink a long time. A month ago I tried to drink another neurodegenerative. I just wanted to change my medicine. And I drink pentovit tablets, i.e. vitamins of group B. It seems that again I will switch to nayz. I am 55 years old.
Guests
Irina
I drink tablets nizz from a toothache, on a nose a holiday, on polyclinics to go there is no time, houses except for naza,as an anti-inflammatory drug was nothing, instructions too, since the tablets before that were not intended for me and were in sufficient balance. Today, the first day of taking four cups of tablets, tomorrow I'll drink two or three, it helps.
Guests
a
After a bath she chilled her lower back. Pain, a day later there was an ache in the body. I could not walk actively, as before. Constant malaise and bad mood. Compress turpentine removed only acute pain. So tormented a week. I am 70 years old, do not drink any tablets. But yesterday, having tested the pendulum effect on a bad condition, at night I drank 1 tablet of 100 mg Naise. In the morning I woke up healthy, no pain in the lower back, or aches in the body. It's great.

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