Akupan Biokodeks - instructions for use, analogs, reviews and release forms (injections in ampoules for injections in a solution of 10 mg in 1 ml) of the drug for the treatment of head, dental, postoperative and other types of pain in adults, children and pregnancy

In this article, you can read the instructions for using the drug Acupan Biocodex. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Akupan Biocodex in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Akupan Biocodexes in the presence of existing structural analogues.Use for the treatment of head, dental, postoperative, post-traumatic and other types of pain in adults, children, as well as during pregnancy and lactation.

Acupan Biocodex an analgesic of central action. The mechanism of action, apparently, is related to the effect on the dopamine, norepinephrine and serotonin receptors in the central nervous system (CNS). It has some M-cholinolytic and sympathomimetic activity. The chemical structure and properties of nefopam (the active substance of the drug Akupan Biocodex) do not allow attributing it to either opioid analgesics or to non-steroidal anti-inflammatory drugs (NSAIDs). Does not have anti-inflammatory and antipyretic effects. Does not affect the blood coagulation system and does not cause irritation of the gastric mucosa.

Composition

Nefopam + auxiliary substances.

Pharmacokinetics

After the administration of one dose (20 mg) of Akupan Biocodex, the maximum intramuscular concentration in the serum is observed after 30-60 minutes. Binding to plasma proteins is 71-76%. Biotransformation of the drug is significant, three metabolites have been identified: desmethylnepopam, nefopam N-oxide and N-glucuronide nefopam.Desmethylnepopham and nefopam N-oxide do not glucuronize in the liver, do not exhibit analgesic activity in animal studies. 87% of the administered dose of the drug is excreted by the kidneys, less than 5% is excreted unchanged.

Indications

• headache;
• toothache;
• postoperative pain;
• rheumatic pains;
• pain in the joints and bones;
• pain of internal organs;
• pain in trauma and post-traumatic pain;
• anesthesia in preparation for surgery;
• anesthesia during dental procedures and operations;
• anesthesia of childbirth and in the postpartum period;
• pain with menstruation;
• neuropathic pain.

Forms of release

Solution for infusion and intramuscular injection of 10 mg in 1 ml (injections in ampoules for injection).

Instructions for use and dosing regimen

The dose should correspond to the intensity of the pain syndrome and the patient's reaction.

Intramuscular administration: Acupant Biocode should be administered intramuscularly deep. The recommended dose per administration is 20 mg. If necessary, the administration is repeated every 6 hours. The maximum daily dose is 120 mg.

Intravenous administration: the drug should be administered as an intravenous infusion lasting at least 15 minutes, the patient should be in a prone position. The recommended dose per administration is 20 mg.If necessary, the administration is repeated every 4 hours. The maximum daily dose is 120 mg.

Method of intravenous administration: Acupane Biocode can be administered in a usual solution for infusions (0.9% solution of sodium chloride or 5% solution of dextrose). The optimum ratio at dilution is the contents of one ampoule of the preparation and 50 ml of the solution for infusions.

The course of treatment is no more than 8-10 days.

Side effect

• sweating;
• drowsiness;
• nausea, vomiting;
• Atropine-like reactions (dry mouth, fainting, urinary retention, irritability, agitation);
• tachycardia (rapid heart rate) and increased blood pressure;
• urticaria, angioedema, anaphylactic shock;
• nervousness;
• disturbance of thinking;
• headache;
• sensation of a veil before the eyes;
• euphoria;
• convulsions;
• hallucinations;
• drug dependence.

Contraindications

• hypersensitivity to nefopam or other components of the drug;
• age up to 12 years;
• convulsions or their presence in the anamnesis;
• epilepsy;
• risk of urinary retention caused by damage to the urethra and prostate;
• risk of developing acute glaucoma;
• pregnancy, the period of breastfeeding.

Application in pregnancy and lactation

Contraindicated in the use of Akupan Biokodeksa during pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children under 12 years.

Application in elderly patients

Use with caution in the elderly.

special instructions

Use with caution in patients with glaucoma, urinary retention, prostatic hypertrophy, impaired liver or kidney function, with tachycardia, as well as in the elderly.

Clinical experience of using Akupan Biocodex in patients with myocardial infarction is insufficient.

It is not recommended to use it with simultaneous treatment with monoamine oxidase (MAO) inhibitors. Use with caution in patients receiving antidepressants.

Against the backdrop of treatment, a reversible pink staining of urine is possible, which has no clinical significance.

Impact on the ability to drive vehicles and manage mechanisms

With caution apply Akupan Biokodeks in patients engaged in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Drug Interactions

Contraindicated reception Acupan BioCode with sympathomimetics and M-anticholinergic medications. They enhance the drug's side effects, especially in the case of simultaneous administration with him atropine antispasmodics, M-anticholinergic antiparkinsonian drugs imipraminovyh phenothiazine neuroleptics and antidepressants, blockers of histamine H1-receptor, disopyramide.

Analogues of drug Akupan Biocodex

Structural analogs for the active substance:

• Nefopam Anta;
• Oxadol.

Analogs Acupan Biocodex preparation of a pharmacological group (other non-narcotic analgesics, including non-steroidal anti-inflammatory agents and others):

• Abisil;
• Azulan;
• Actasulide;
• Amoeolin;
• Angidak;
• Aponil;
• Ardalon;
• Arthro-Active;
• Arthrodarin;
• Артрокер;
• Arthrofoon;
• Askalcin;
• Aulin;
• Benzydamine;
• Broxinac;
• Bronflex;
• Wobenzym;
• Galavit;
• Gastrofungin;
• Glycyrs;
• Humisol;
• Diartrin;
• Diacerein;
• Donalgin;
• Influbene;
• Kaleflon;
• Catadolone;
• Kvarelin;
• Mesulide;
• Nyz;
• Nysulid;
• Naqvan;
• Neurodolone;
• Nekstrim Active;
• Nemux;
• Nimegesic;
• Nimesan;
• Nimesil;
• Nimesulide;
• Nimika;
• Nimulid;
• Niflugel;
• Nifluryl;
• Novolide;
• Nolodates;
• Oxadol;
• Pirabutol;
• Plasmol;
• Prolid;
• Reglis;
• Relaphene;
• Remidon;
• Sulaydine;
• Tantum Verde;
• Tysol;
• Falimint;
• Phlogenzyme;
• Floiled;
• Flugesic;
• Citralgin.

Surgeon's doctor's opinion

The drug Akupan Biokodeks is a good powerful anesthetic. In his department, we assign him to the patient for several days after surgery to relieve postoperative pain. We administer the drug intramuscularly on average 2-4 times a day, depending on the severity of the pain syndrome. Since we use Akupan Biocode in short courses, in my practice there was not a single case of addiction or the formation of drug dependence, which may be accompanied by withdrawal syndrome. The patients carry the drug well, sometimes complain of nausea, dry mouth, drowsiness. After the pain medication is stopped, all these symptoms disappear.

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