Aulin - instructions for use, analogs, reviews and release forms (100 mg tablets, granules or powder for the preparation of a solution) of the drug for relieving pain with menstruation, arthrosis, arthritis, in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Aulin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Aulina in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Aulina in the presence of existing structural analogues. Use for pain relief with monthly, arthrosis, arthritis, bruises, sprains in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Aulin - Non-steroidal anti-inflammatory drug (NSAID), in the structure of which there is a sulfonilide group. It is believed that Nimesulide (the active substance of the drug Aulin) refers to selective inhibitors of cyclooxygenase-2 (COX-2). Has a pronounced anti-inflammatory, as well as analgesic and to a lesser degree antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis. Suppresses the synthesis of prostaglandins in the inflammation region to a greater extent than in the gastric mucosa or kidneys, which is due to the inhibition of predominantly COX-2. In addition, in the mechanism of anti-inflammatory action of nimesulide, its ability to inhibit the formation of free oxygen radicals (without affecting haemostasis and phagocytosis) is important and inhibit the release of the myeloperoxidase enzyme.

Composition

Nimesulide + excipients.

Pharmacokinetics

With oral administration, Aulin is absorbed well. Up to 97.5% of the substance binds to plasma proteins. Metabolised in the liver. The main metabolite is parahydroxy-form, which has pharmacological activity.Hydroxynimesulide is the only metabolite in plasma and almost completely in a free state. It is allocated mainly in urine (approximately 50% of the administered dose). Only 1-3% is excreted unchanged. Approximately 29% of the administered nimesulide is excreted after biotransformation with feces. Repeated use of the drug does not lead to cumulation, but it is contraindicated in patients with impaired liver function because of the high risk of cumulation.

Indications

• arthritis, osteoarthritis (arthrosis, osteoarthritis);
• extra-articular rheumatic diseases;
• pain and inflammation after surgery;
• pain and fever in acute inflammatory processes in the upper respiratory tract;
• pain associated with dysmenorrhea (pain with menstruation);
• polyarthrosis;
• toothache;
• bruises and sprains;
• tendonitis (tendon inflammation);
• Bursitis (inflammation of the periarticular bag).

Forms of release

Tablets of 100 mg.

Granules for the preparation of a solution for ingestion 100 mg (sometimes mistakenly called powder).

Medicinal forms in the form of gel ointment at the time of publication of the drug in the Directory did not exist.

Instructions for use and dosing regimen

Aulin taken orally after eating. Dissolve the contents of the sachet in 80-100 ml of water. The prepared solution is not subject to storage.

Adults: the recommended dosage is 100 mg (1 tablet or 1 packet of granules) 2 times a day. If necessary, the dosage can be increased to 200 mg 2 times a day, depending on the severity of the course of the disease. The duration of treatment depends on the clinical effect.

Patients with minor renal impairment (creatinine clearance - 30-80 ml per minute) dose adjustment is not required. When prescribing the drug, patients with renal insufficiency (creatinine clearance less than 30 ml per minute) should be careful (if necessary, the dosage in such patients can be reduced).

Side effect

• rash, hives, itching;
• erythema (severe reddening of the skin caused by the expansion of capillaries);
• angioedema (edema of Quincke);
• Stevens-Johnson syndrome;
• epidermal necrolysis (Lyell's syndrome);
• heartburn, nausea;
• abdominal pain (abdominal pain);
• diarrhea, constipation;
• peptic ulcers, perforated (perforated) ulcers;
• gastrointestinal bleeding;
• changes in hepatic enzymes (transaminases), more often temporary and reversible;
• acute hepatitis (inflammation of the liver);
• fulminant hepatic insufficiency (several lethal outcomes);
• drowsiness, restlessness;
• headache, dizziness;
• oliguria (decrease in the amount of urine released by the kidneys);
• edema;
• isolated hematuria (blood in the urine);
• kidney failure;
• leukopenia, anemia, agranulocytosis, lengthening bleeding time, hematuria, purpura, thrombocytopenia;
• anaphylactic reactions in the form of dyspnea (dyspnea), asthma attacks, mainly in patients with allergy to aspirin (acetylsalicylic acid) and other NSAIDs.

Contraindications

• hypersensitivity, including aspirin or other NSAIDs in anamnesis (bronchospasm, rhinitis, urticaria);
• acute peptic ulcers;
• erosive and ulcerative lesions of the gastrointestinal tract (GIT);
• gastrointestinal bleeding;
• disorders of the blood coagulation system;
• severe renal dysfunction, hepatic impairment;
• children's age till 12 years;
• with caution: arterial hypertension, heart failure, diabetes mellitus.

Application in pregnancy and lactation

The drug Aulin should not be prescribed during pregnancy or breastfeeding.

Use in children

Contraindicated in children under 12 years.

Application in elderly patients

Patients over 65 years of age are recommended to use the minimum effective dose of the drug.

Elderly patients are particularly prone to developing side effects of NSAIDs. Long-term therapy with NSAIDs is not recommended for older patients.

special instructions

Use the lowest effective dose for a short period of time.

The drug should be administered with caution to patients suffering from liver disease, especially in combination with other hepatotoxic drugs. Patients taking long-term NSAIDs, as well as with symptoms of hepatocellular damage (eg, anorexia, nausea, vomiting, abdominal pain, weakness, darkening of urine or jaundice) who take nimesulide should undergo a regular clinical examination. When pathological results of liver function tests should be discontinued treatment. The resumption of nimesulide therapy in these patients is not indicated.

Side effects from the liver occur less than 1 month after the start of therapy with the drug. In rare cases, with the occurrence of gastrointestinal bleeding or gastrointestinal ulcers in patients taking Aulin, therapy should be abolished.As with other NSAIDs, gastrointestinal bleeding or ulceration / perforated ulcers can occur at any treatment period with or without prior symptoms or anamnestic information about gastrointestinal lesions.

Patients with renal or heart failure should be cautioned to take NSAIDs, as this leads to progression of kidney disease. Evaluation of the kidney function should be performed before the start of therapy and regularly conducted during the treatment. In case of decompensation, therapy should be suspended.

Aulin should be used with caution in patients with an anamnesis of bowel disease.

Because NSAIDs affect platelet function, they should be used with caution in patients with intracranial hemorrhage and hemorrhagic diathesis. Therapy should be regularly evaluated and, if ineffective, discontinued.

Impact on the ability to drive vehicles and manage mechanisms

Due to the fact that nimesulide ingestion may cause dizziness and drowsiness, it should be used with caution in patients involved in potentially hazardous activities,requiring increased concentration of attention and rapid psychomotor reactions.

Drug Interactions

In the course of the studies, there was no clinically significant interaction with glibenclamide, theophylline, warfarin, digoxin, cimetidine, and antacids.

Aulin decreases the effectiveness of diuretics and, in particular, blocks the furosemide-stimulated increase in renin plasma concentration. Pharmacokinetic analysis of the concentration of nimesulide in patients on continuous therapy with diuretics (furosemide) revealed a clinically insignificant decrease in the volume of distribution.

Aulin increases the effect of Acetylsalicylic acid on hemostasis. The simultaneous use of it with salicylates or tolbutamide can affect the concentration of the latter in the plasma and, consequently, their clinical effectiveness.

NSAIDs reduce the clearance of lithium, which leads to an increase in plasma concentrations and the development of toxic effects (with the appointment of nimesulide, patients who are undergoing lithium salt therapy should regularly determine its concentration).

Analogues of the drug Aulin

Structural analogs for the active substance:

• Actasulide;
• Amoeolin;
• Aponil;
• Mesulide;
• Nyz;
• Nysulid;
• Nemux;
• Nimegesic;
• Nimesan;
• Nimesil;
• Nimesulide;
• Nimika;
• Nimulid;
• Novolide;
• Prolid;
• Sulaydine;
• Fllolid.

Analogues of the drug Aulin on the pharmacological group (other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs):

• Abisil;
• Azulan;
• Alor;
• Amoeolin;
• Angidak;
• Antigrippin;
• Ardalon;
• Arthro-Active;
• Arthrodarin;
• Артрокер;
• Arthrofoon;
• Askalcin;
• Benzydamine;
• Broxinac;
• Bronflex;
• Wobenzym;
• Galavit;
• Gastrofungin;
• Glycyrs;
• Humisol;
• Diartrin;
• Diaflex;
• Diacerein;
• Donalgin;
• Zinaksin;
• Insty;
• Influbene;
• Kaleflon;
• Catadolone;
• Kvarelin;
• Mesulide;
• MuV;
• Nyz;
• Naqvan;
• Neurodolone;
• Nemux;
• Nimesulide;
• Nimika;
• Nimulid;
• Niflugel;
• Nolodates;
• Oxadol;
• Oralcept;
• Pirabutol;
• Plasmol;
• Reglis;
• Relaphene;
• Remidon;
• Reopyrin;
• Romazulan;
• Rotokan;
• Rumalaya;
• Salvar;
• Symmetrad;
• Tantum Verde;
• Tysol;
• Tanflex;
• Falimint;
• Phlogenzyme;
• Flugesic;
• Citralgin;
• Evkarom.

Response of a therapist

Aulin is a drug that I widely use in my practice. I assign him sick respiratory infections with severe fever, patients with inflammatory-degenerative diseases of the joints,with postoperative pain. Aulin well cures toothache and pain with menstruation. In this case, patients note that the tablets and the solution prepared from the granules are equally effective. With regard to adverse reactions, the most frequent are dizziness, heartburn and nausea. There were no other undesirable effects during Aulin's treatment in my practice.

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