Terizidone - instructions for use, reviews, analogs and forms of release (capsules or tablets 150 mg, 250 mg and 300 mg) drugs for the treatment of various forms of pulmonary tuberculosis and other organs in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Terizidone. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Terizidone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Terizidon in the presence of existing structural analogues.Use to treat various forms of tuberculosis of the lungs and other organs in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Terizidone antituberculous antibiotic. Has a wide spectrum of antimicrobial action. It acts bacteriostatically. It is active against Mycobacterium tuberculosis (Mycobacterium), Mycobacterium bovis, Mycobacterium avium, as well as Staphylococcus aureus (Staphylococcus aureus) and Staphylococcus epidermidis. Enterococcus faecalis (Enterococcus), Escherichia coli (E. coli), Citrobacter spp., Enterobacter spp., Morganella morganii, Klebsiella pneumoniae (Klebsiella) and Pseudomonas aeruginosa are also sensitive. Development of secondary resistance is rare. Cross-resistance with other anti-tuberculosis drugs is not observed.

Composition

Terizidone + excipients.

Pharmacokinetics

Absorption from the gastrointestinal tract (GIT) - 70-90%, eating does not affect the rate of absorption. Time to reach the maximum concentration in the blood - 2-3 hours. It is well distributed in tissues and body fluids (lungs, bile, ascitic fluid, pleural effusion, synovial fluid, lymph, sputum). Penetrates into the cerebrospinal fluid (CSF) - 80-100% of the concentration in the blood serum. A higher concentration in CSF is created by inflammatory changes in the meninges.Metabolized slightly. It is excreted by the kidneys (in unchanged form - 60-70%), intestines - a small amount in unchanged form and in the form of metabolites.

Indications

• tuberculosis;
• tuberculosis of the respiratory system, including pulmonary tuberculosis, confirmed bacteriologically and histologically;
• lupus;
• tuberculous meningitis;
• tuberculosis of other organs.

Forms of release

Capsules 150 mg, 250 mg and 300 mg (sometimes mistakenly called tablets).

Instructions for use and dosing regimen

Inside, regardless of food intake: adults and children over 14 years old and weighing less than 60 kg - 300 mg twice a day (600 mg per day). Patients with a body weight of 60-80 kg - 300 mg three times a day (900 mg per day). Adults with a body weight of more than 80 kg - 600 mg twice a day (1200 mg per day). Accept for 3-4 months.

When creatinine clearance (CK) is less than 30 ml per minute, the dose and the frequency of intake are reduced.

Side effect

• headache, dizziness;
• increased excitability;
• tremor (fast, rhythmic movements of limbs or trunk);
• insomnia;
• feeling of intoxication;
• epileptiform convulsions;
• depression, psychosis;
• abdominal pain (abdominal pain);
• flatulence (bloating);
• diarrhea;
• allergic reactions.

Contraindications

• organic diseases of the central nervous system (CNS), including cerebrosclerosis (atherosclerosis of cerebral vessels);
• epilepsy;
• mental disorders;
• alcoholism;
• pregnancy;
• lactation period (breastfeeding);
• children's age till 14 years;
• hypersensitivity to terizidone.

Application in pregnancy and lactation

Contraindicated in the use of Terizidon during pregnancy and lactation.

Use in children

Contraindicated in children under 14 years.

Application in elderly patients

Caution should be used in elderly patients.

special instructions

Caution should be used in patients with chronic heart failure, with chronic renal failure, in elderly patients.

Terizidone can cause deficiency of cyanocobalamin and / or folic acid, it is necessary to conduct appropriate examination and treatment.

It should be monitored monthly for blood and urine, liver function, namely the level of enzymes alanine aminotransferase (ALT), aspartate aminotransferase (ACT) and bilirubin.

Patients should avoid the use of ethanol (alcohol), since simultaneous administration with Terizidon increases the incidence of side effects (up to the development of seizures).

In connection with the possibility of developing adverse reactions from the nervous system (depression, behavior change), it is necessary to monitor the patient's mental status.

Impact on the ability to drive vehicles and manage mechanisms

During treatment with Terizidone, it is necessary to refrain from driving vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

Ethanol (alcohol) increases the risk of epileptic seizures.

When used simultaneously with ethionamide, there is an increased risk of side effects from the CNS (especially seizures).

Simultaneous application of terizidone with Isoniazid increases the incidence of dizziness, drowsiness.

Analogues of the drug Terizidone

Structural analogs for the active substance:

• Loxidone;
• Resonizant;
• Terizidon Mack;
• Tysidone.

Analogues of the drug Terizidon on the pharmacological group (other synthetic antibacterial agents):

• Aquapasque;
• Amictobin;
• Aminosalicylic acid;
• Apputol;
• Acetarsol;
• Verpas SR;
• Hydroxychloroquine;
• Deflamon;
• Dixin;
• Dioxin oxide;
• Eckox;
• Zukoks;
• Iso-Eremfat;
• Isocomb;
• Isoniazid;
• Isopasc;
• Imbact;
• Canison;
• Quinizole;
• Clotrimazole;
• Combine;
• Combubutol;
• Laslonvita;
• Levofloripine;
• Lomecombe;
• Mairin;
• IAC PAS;
• Metroxan;
• Metronidazole;
• Mefloquine;
• Monopas;
• Neo Penotran;
• Nifuratel;
• Ornidazole;
• Osarbon;
• Paser;
• PASK;
• Pisina;
• Pyrazinamide;
• Pirafat;
• Plaquenil;
• Prothionamide;
• Protomide;
• Protub;
• Protubitis;
• Protubipira;
• Protubutin;
• Protubetam;
• Resonizant;
• Ripeg;
• Rifakomb;
• Reefater;
• Saladez;
• Simpas;
• Sirturo;
• Tizamide;
• Tubavit;
• Faminoalk;
• Forkoks;
• Phtivazide;
• Phthisoactive;
• Phthisopyrum;
• Elufour;
• Ethambutol;
• Ethionamide;
• This is ethomide.

Phthisiatric doctor's opinion

In our department, the drug Terizidone is taken by patients not only with tuberculosis of the respiratory organs, but also with tuberculous lesions of the skin, bones and other organs. The daily dose is selected individually for each patient according to his body weight and divided into two or three doses. The course of treatment, as a rule, lasts at least 4 months.But despite this duration, adverse reactions to the administration of Terizidone are rare. Only a few patients report unexpressed headaches, dizziness. There were cases of allergic reactions in the form of skin spotted rashes, accompanied by itching.

Similar medicines:

Other medicines: