Metrovagin - instructions for use, analogs, reviews and release forms (500 mg vaginal suppository) for the treatment of trichomoniasis and nonspecific vaginitis in women, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Metrowagin. Presented are reviews of visitors to the site - consumers of this medication, as well as the opinions of physicians specialists on the use of Metrovagin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Metrovagin in the presence of existing structural analogues. Use for the treatment of trichomoniasis and nonspecific vaginitis in women, children, as well as in pregnancy and lactation. Composition of the preparation.

Metrowagin antiprotozoal drug.It is believed that the mechanism of action is associated with a violation of the structure of deoxyribonucleic acid (DNA) of sensitive microorganisms. Metronidazole (the active substance of the drug Metrovagin) is active against Trichomonas vaginalis (Trichomonas), Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, and obligate anaerobic bacteria (including Bacteroides spp., Fusobacterium spp.). Metronidazole is resistant to aerobic microorganisms. In combination with Amoxicillin it shows activity against Helicobacter pylori (Helicobacter pylori). It is believed that amoxicillin inhibits the development of Helicobacter pylori resistance to metronidazole.

Composition

Metronidazole + auxiliary substances.

Pharmacokinetics

After intravaginal application metronidazole is absorbed insignificantly. Bioavailability of metronidazole for intravaginal application is 19%. The active ingredient is metabolized in the liver. It is allocated on 40-70% (about 20% - in the unmodified form) through kidneys.

Indications

• trichomoniasis in women, including trichomonas colpitis / vaginitis (inflammation of the vaginal mucosa);
• nonspecific vaginitis.

Forms of release

Vaginal suppositories 500 mg (vaginal suppositories).

Other dosage forms, namely tablets, at the time of publication of the drug in the Directory did not exist.

Instructions for use and dosing regimen

Intravaginally, after releasing the suppository from the contour package using scissors (cut the film along the contour of the suppository), deep into the vagina.

Trichomonas vaginitis: 1 suppository per day for 10 days.

Nonspecific vaginitis: 1 candle 2 times a day for 7 days.

Side effect

• itching, burning, pain and irritation in the vagina;
• thick, white, mucous discharge from the vagina without smell or with a faint odor;
• frequent urination;
• after the withdrawal of the drug, the development of candidiasis of the vagina;
• sensation of burning or irritation of the penis in the sexual partner;
• nausea;
• change in taste;
• metallic taste in the mouth;
• dry mouth;
• decreased appetite;
• spastic pain in the abdominal cavity;
• nausea, vomiting;
• constipation or diarrhea;
• allergic reactions: urticaria, itching of the skin, rash;
• leukopenia or leukocytosis;
• rarely - staining the urine in a red-brown color due to the presence of a water-soluble pigment, formed as a result of metronidazole metabolism.

Contraindications

• increased sensitivity to metronidazole or other nitroimidazole derivatives;
• diseases of the blood, leukopenia (including in the anamnesis);
• violation of coordination of movements;
• organic lesions of the central nervous system (CNS), including epilepsy;
• hepatic failure (in the case of the appointment of large doses);
• pregnancy;
• the period of breastfeeding.

Application in pregnancy and lactation

Metrovagin quickly penetrates the placental barrier. In 2 and 3 trimesters of pregnancy, metronidazole is used only for vital indications.

Metronidazole is excreted in breast milk. If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

Use in children

In combination with amoxicillin is not recommended for use in patients younger than 18 years.

special instructions

Treatment with metruvagine should not last more than 10 days and repeat more often than 2-3 times a year.

When treatment is recommended to abstain from sexual intercourse. With vaginitis caused by Trichomonas vaginalis, simultaneous treatment of the sexual partner with the drug metronidazole for oral administration is recommended.

In the case of using the drug in conjunction with metronidazole for oral administration, especially in the second course, control of the picture of peripheral blood (danger of leukopenia) is necessary.

During the period of treatment, ethanol (alcohol) is contraindicated, since a disulfiram-like reaction is possible (spasmodic pains in the abdomen, nausea, vomiting, headache, sudden rush of blood to the face).

Impact on the ability to drive vehicles and manage mechanisms

It is necessary to pay attention of patients, especially drivers of vehicles and persons operating other mechanisms, to the possibility of dizziness associated with taking the drug.

Drug Interactions

Compatible with sulfonamides and antibiotics. In the treatment of metruvagine, alcohol intake should be avoided (similarly Disulfiram causes alcohol intolerance). Do not combine metronidazole with disulfiram, since the interaction of these drugs may inhibit consciousness, the development of mental disorders.

When used simultaneously with Warfarin and other indirect anticoagulants, metronidazole enhances their effect. It is not recommended to combine with nondepolarizing muscle relaxants (vecuronium bromide).

Under the influence of barbiturates, the effect of metronidazole may decrease, since its inactivation in the liver is accelerated.

Cimetidine depresses the metabolism of metronidazole, which can lead to an increase in its concentration in the blood serum and an increased risk of developing adverse reactions.

With simultaneous administration with lithium preparations, the concentration of the latter in plasma can increase.

Analogues of the drug Metrovagin

Structural analogs for the active substance:

• Bacimex;
• Deflamon;
• Clion;
• Metrogil;
• Metroxan;
• Metrolacker;
• Metron;
• Metronidazole;
• Metronidal;
• Metroseptol;
• Nirmet;
• Orvagil;
• Rosamet;
• Rosex;
• Siptrogyl;
• Tricho-pin;
• Trichobrol;
• Trichopol;
• Trichosept;
• Flagel;
• Edgil;
• Efloran.

Analogues of the drug Metrovagin on the pharmacological group (other synthetic antibacterial agents):

• 5-NOC;
• Avrazor;
• Adisord;
• Aquapasque;
• Bacimex;
• Vagisept;
• Gainomax;
• Gynocaps;
• Dazolik;
• Daraprim;
• Delagil;
• Dioxydin;
• Dioxysol;
• Isoniazid;
• Candisol;
• Kanesten;
• Levofloripine;
• Lidaprim;
• Mairin;
• McMiore;
• Mannitol;
• Metronidazole;
• Metronidal;
• Metroseptol;
• Nitazol;
• Nifuroxazide;
• Orvagil;
• Ornidazole;
• Paser;
• Pyrazinamide;
• Plaquenil;
• Rifinag;
• Rosamet;
• Simpas;
• Stoppier;
• Streptonitol;
• Tager;
• Thioacetazone;
• Trimopan;
• Trichopol;
• Urotavenol;
• Urofuragin;
• Fazijin;
• Furagin;
• Furadonin;
• Furazolidone;
• Furasol;
• Furacilin;
• Tsifran;
• Edgil;
• Ecofuril;
• Enterofuryl;
• Ersefuril;
• Etambusin;
• Ethambutol;
• Ethid;
• Ethionamide;
• Ethomide;
• Efloran.

Response of a gynecologist

A good tool for treating women with vaginitis and vulvovaginitis of various etiologies. Especially effective are metrovagin suppositories in the treatment of trichomonatal colpitis (vaginitis). Approximately on the 5th-6th day, discharge from the vagina disappears, the women cease to disturb the itching of the genital organs. Do not always agree to be treated by sexual partners, which provokes a relapse of the disease. It should be noted that adverse reactions to treatment with metrogonavine vaginal suppositories are extremely rare. There were cases when women complained of burning and pain in the vagina. But after the treatment, all these symptoms disappeared.

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