Reopoliglyukin - instructions for use, reviews, analogs and forms of release (solution for infusions or droppers 100 ml, 200 ml, 250 ml, 400 ml, 500 ml and 1000 ml dextran) of the drug for the treatment of shock in adults, children and pregnancy

In this article, you can read the instructions for using the drug Reopoliglukin. The reviews of the visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Reopoliglyukin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Reopoliglyukin in the presence of existing structural analogues.Use to treat shock and hypovolemia in adults, children, as well as during pregnancy and lactation.

Reopoliglukin - solutions of high molecular weight dextran with sodium chloride, glucose or mannitol, are polyfunctional plasma-substituting solutions. Normalize hemodynamics, increase the volume of fluid in the bloodstream. Solutions of low-molecular dextran, in addition, contribute to improving microcirculation, reduce the aggregation of blood cells, the viscosity of the blood. Solutions of dextran containing mannitol, also have osmodiuretic effect.

Promotes the movement of fluid from tissues into the bloodstream, increases the suspension properties of blood, reduces its viscosity, helps restore blood flow in small capillaries, prevents and reduces the aggregation of uniform elements. The increase in plasma volume is most pronounced in the first 90 minutes after the administration of Rheopolyglucin. Each gram of dextran promotes the passage of 20-25 ml of fluid from the tissue into the bloodstream.

Composition

Dextran with a molecular weight of 30,000 to 40,000 + excipients.

Dextran with a molecular weight from 35 000 to 45 000 + auxiliary substances (Reopoliglyukin 40).

Pharmacokinetics

It is excreted by the kidneys (on the first day up to 70%).

Indications

• violation of capillary blood flow;
• prevention and treatment of shock (traumatic, surgical, burn);
• compression syndrome;
• prevention and treatment of thrombosis, thrombophlebitis, endarteritis;
• heart operations performed using an artificial circulation device (for addition to a perfusion fluid);
• improvement of local circulation in vascular and plastic surgery;
• detoxification (for burns, peritonitis, pancreatitis, etc.);
• diseases of the retina and optic nerve;
• inflammatory processes of the cornea and choroid.

Dextran with a molecular weight of 1000:

• prevention of severe allergic reactions to intravenous administration of dextran solutions.

Forms of release

Solution for infusions (droppers) in containers or bottles of 100 ml, 200 ml, 250 ml, 400 ml, 500 ml and 1000 ml.

Instructions for use and dosing regimen

Intravenously, drip (in the form of droppers).

The dose is set individually and depends on the clinical situation and the patient's condition.

To prevent and treat violations of capillary blood flow associated with traumatic, surgical and burn shock, intravenous drip 400-1000 ml per day (for at least 30-60 minutes) is usually 1 (rarely 2) times a day.

In surgical interventions on the heart and vessels, intravenous drip of 10 ml / kg is administered before the operation, 400-500 ml during the operation and 10 ml / kg per injection for 5-6 days after the operation.

Children the total dose should not exceed 15 ml / kg per day.

In cardiovascular operations, children under the age of 2-3 years are administered 10 ml / kg once a day (for 60 min), up to 8 years - 7-10 ml / kg (1-2 times per day), up to 13 years - 5-7 ml / kg (1-2 times a day), over 14 years - a dose for adults. For detoxification, 5-10 ml / kg is administered within 60-90 minutes.

In operations with artificial circulation, Reopoliglyukin is added to the blood at the rate of 10-20 ml / kg of body weight to fill the oxygenator pump. Concentration of Rheopolyglucinum in a perfusion solution should not exceed 3%. In the postoperative period the drug is used in the same doses as in the treatment of shock conditions.

For the purpose of detoxification, I / drip in a single dose from 500 to 1200 ml (in children 5-10 ml / kg) for 60-90 min.If necessary, you can pour another 500 ml of the drug in the first day (in children the administration of the drug in the first day can be repeated in the same doses). In the following days, the drug is administered drip, adults - in a daily dose of 500ml, children - at a rate of 5-10 ml / kg. It is advisable to jointly introduce crystalloid solutions (Ringer, Ringer-acetate, etc.) in such quantities as to normalize the water-electrolyte balance (especially important in the treatment of dehydrated patients and after surgical operations). The drug, as a rule, causes an increase in diuresis (a decrease in diuresis indicates dehydration of the patient's body).

In ophthalmic practice is used by electrophoresis. The procedure is carried out once a day. Apply 10 ml (from the positive and negative pole, the current density to 1.5 mA / cm2).

Side effect

• allergic reactions (redness of the skin, rashes on the skin, nausea, fever, anaphylactic shock);
• arterial hypotension.

Contraindications

• trauma to the skull with increased intracranial pressure, cerebral hemorrhage and other cases where the introduction of a large amount of fluid is not indicated;
• oliguria and anuria due to organic kidney disease;
• heart failure;
• violations of coagulation and hemostasis;
• propensity to allergic reactions;
• diabetes mellitus and other disorders of carbohydrate metabolism (for solutions with glucose).

special instructions

In connection with possible allergic reactions, the first 10-20 ml of the infusion solution is recommended to be administered slowly, observing the patient's condition. Given the possibility of developing hypertension, it should be borne in mind that appropriate means for intensive care may be required.

Causes an increase in diuresis (if there is a decrease in diuresis with the release of viscous syrupy urine, this may indicate dehydration, in this case it is necessary to introduce / in colloid solutions to replenish and maintain the water-electrolyte balance). In patients with reduced filtration capacity of the kidneys, it is necessary to limit the administration of sodium chloride.

Dextran with a molecular weight of 1000 can not be diluted or mixed with dextran solutions for infusions. Dextran with a molecular weight of 1000 can be administered I / O via the Y-branch or the rubber tube of the infusion system, provided that during the injection there is no significant dilution of the drug.

With a drop in temperature during the transport of the drug, white films, which are dextran particles, may appear. In this case, it is necessary to dissolve the film by heating the bottle with the preparation in a boiling water bath for 1 hour with periodic shaking or autoclaving at 120 degrees Celsius for 20 minutes, cool the preparation to body temperature and use as directed.

Dextrans are able to envelop the surface of red blood cells, preventing the determination of the blood group, so for analysis it is necessary to use washed red blood cells.

Drug Interactions

Together with the preparation, it is advisable to administer crystalloid solutions (0.9% sodium chloride solution, 5% Dextrose solution) in such quantity as to replenish and maintain the water-electrolyte balance. This is especially important in the treatment of dehydrated patients and after severe surgical operations.

Analogues of the drug Reopoliglyukin

Structural analogs for the active substance:

• Hemostabil;
• Dextran 40;
• Dextran 70;
• Longasteril 40;
• Polyglukine;
• Polyglucin is dry;
• Reogluman;
• Reodex;
• Reomacrodex;
• Reopoliglyukin 40;
• Reopoliglyukin dry;
• Reopoliks.

Analogues for the pharmacological group (substitutes for plasma and other blood components):

• Albiomin 20%;
• Albumen;
• Albumin 10%;
• Human albumin;
• Alburex;
• Venofundin;
• To the Voles;
• Voluven;
• Volulayt;
• Geloplasmic balance;
• Hemodez;
• Hemopure;
• Hemostabil;
• Hemohes 10%;
• Hemohes 6%;
• Hydroxyethyl starch;
• Glucose solution for infusion;
• Dextran 40;
• Dextran 70;
• Dextrose;
• Gelatine;
• Zenalb;
• Infukol GEC;
• Ionoches;
• Krasgemodez 8000;
• Custodiol;
• Levulose;
• Longasteril 40;
• Sodium fumarate is complex;
• Neohemodeisis;
• Neorondex;
• Perftoran;
• Plasbumin 20;
• Plasma for fractionation;
• Plazmaline;
• Plasmastabil 200;
• Povidone;
• Polyvinylpyrrolidone;
• Polyglukine;
• Polyglucin is dry;
• Polyoxidin;
• Polyoxyfumarin;
• Proxanol;
• Protein;
• Pfokalin;
• Pforidine;
• Ringer's solution;
• Hartmann's solution;
• Reogluman;
• Reodex;
• Reomacrodex;
• Rheopolyglucin with glucose;
• Reopolydex;
• Rheosorbylact;
• Refortan HES 10%;
• Refortan HES 6%;
• Ringer;
• Ringer lactate;
• Ringer's acetate;
• Seprotin;
• Sorbilact;
• Stabisol HES 6%;
• Tetraspan;
• Uman albumin.

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