Drastop - instructions for use, reviews, analogs and forms of release (injections in ampoules for intramuscular injection of 2 ml) drugs for the treatment of arthrosis, osteochondrosis of the spine in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Drustop. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of the chondroprotector Drastop in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Drustop in the presence of existing structural analogues. Use for the treatment of arthrosis, osteochondrosis of the spine in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Drustop - A drug that affects the phosphorus-calcium metabolism in the cartilaginous tissue is a high molecular weight mucopolysaccharide. Slows the resorption of bone tissue and reduces calcium loss, accelerates the recovery of bone tissue, inhibits the process of degeneration of cartilaginous tissue. Prevents the compression of connective tissue and plays the role of a kind of lubrication of articular surfaces. With external application slows the progression of osteoarthritis. Normalizes metabolism in hyaline tissue. Stimulates the regeneration of articular cartilage.

When using the drug, soreness decreases and mobility of affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy.

In the treatment of degenerative joint changes accompanied by a secondary synovitis, the effect is observed after 2-3 weeks from the start of the course.

Having structural similarity with heparin, it can potentially prevent the formation of fibrin clots in the synovial and subchondral microcirculatory bed.

Composition

Chondroitin sodium sulfate + excipients.

Pharmacokinetics

After intramuscular injection of chondroitin, sodium sulfate is readily absorbed. Already 30 minutes after the injection, it is found in the blood in significant concentrations. Chondroitin sodium sulfate accumulates mainly in the cartilaginous tissue that forms the joints. Synovial membrane is not an obstacle to penetration of the drug into the joint cavity. 15 minutes after IM injection of chondroitin, sodium sulfate is found in the synovial fluid, then penetrates into the articular cartilage, where its maximum concentration is reached after 48 hours.

Indications

Diseases of the joints and spine of a degenerative nature, such as:

• intervertebral osteochondrosis and osteoarthrosis;
• osteoarthritis (arthrosis) of peripheral joints.

Forms of release

Solution for intramuscular injection 100 mg in 1 ml (2 ml - 200 mg in 1 ampoule) (injections in ampoules for injection).

Other dosage forms, be it tablets, capsules, ointment or gel at the time of publication of the drug in the Directory did not exist.

Instructions for use and dosing regimen

Intramuscularly. The drug is prescribed for 1 ml (100 mg of chondroitin sodium sulfate) every other day.With good tolerability, the dose is increased to 2 ml (200 mg of chondroitin sodium sulfate) starting with the 4th injection.

The course of treatment - 25-30 injections. If necessary, it is possible to conduct repeated courses of treatment after 6 months.

Side effect

• allergic reactions (skin itch, erythema, urticaria, dermatitis);
• pain and hemorrhages at the injection site;
• dyspepsia;
• angioedema.

Contraindications

• hypersensitivity to the components of the drug;
• bleeding, tendency to bleeding;
• thrombophlebitis;
• children's age (efficacy and safety not established).

Application in pregnancy and lactation

It is not recommended to use Drastop during pregnancy.

During treatment, breastfeeding should be discontinued due to lack of data.

Use in children

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).

Application in elderly patients

There are clinical data on the use of chondroitin sulfate in elderly patients with atherosclerosis, with a slight decrease in the concentration of cholesterol and triglycerides in the blood plasma.

special instructions

With different forms of periodontitis, treatment should be continued for at least 3 months.

To achieve a stable clinical effect, at least 25 injections of the drug are necessary. The effect persists for several months after the end of treatment. To prevent exacerbations, repeated courses of treatment are used.

For allergic reactions or hemorrhages, treatment should be discontinued.

Influence on ability to drive vehicles, mechanisms

The drug Drastop does not affect the ability to drive vehicles and engage in potentially hazardous activities that require increased attention.

Drug Interactions

It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytic agents, which requires more frequent monitoring of coagulation rates when combined.

Drug analogues Drustop

Structural analogs for the active substance:

• Artra Chondroitin;
• Arthravir Inkamfarm;
• Artogistan;
• Artradol;
• Artrafic;
• Arthrin;
• Bioactive extract from small sea fish with chondroitin;
• Injectrin;
• Kartilag Vitrum;
• Structum;
• Hondrogaard;
• Chondroitin;
• Chondroitin sulfate;
• Chondroitin sodium sulfate;
• Chondroxide;
• Chondroxide ointment;
• Chondrolon;
• Honsurid.

Analogues on the pharmacological group (correctors of bone and cartilage tissue metabolism):

• Adelon;
• Actonel;
• Alendercourne;
• Alendronate;
• Alostine;
• Alflutop;
• Alfadol;
• Aminoarthrin;
• Artogistan;
• Arthrakam;
• Arthra;
• Artra MSM forte;
• Arthrin;
• Bonviva;
• Bonefos;
• Veroclast;
• Gialgan Phidias;
• Gialhel gel for the body revitalizing with sodium hyaluronate and Tizol;
• Gialpayer;
• Glucosamine;
• Glucosamine hydrochloride;
• Glucosamine sodium sulphate chloride;
• Don;
• Zoledronic acid;
• Zometa;
• Ibandronic acid;
• Intragel;
• Kondronova;
• Mukosat;
• Sodium fluorate;
• Ostalon;
• Osteogenon;
• Osteotriol;
• Pamidronate medak;
• Piascladin 300;
• Prolia;
• Resoclastine;
• Rizarteva;
• Rumalon;
• Sinoarth;
• Sustagard Artro;
• Sustilac;
• Tevabon;
• Teraflex;
• Teraflex Advance;
• Teraflex Hondrokrem Forte;
• Fosamax;
• Chondraktiv;
• Chondramine;
• Chondroglucide;
• Chondroxide Maximum;
• Forte chondroxide;
• Chondrotek Forte;
• Chondrofen;
• Hondroflex;
• Honsurid;
• Exidgiva;
• Elbon;
• The Unium.

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