Naproxen - instructions for use, analogs, reviews and release forms (tablets 250 mg and 500 mg, ointment or gel, suspension, suppositories) drugs for the treatment of inflammation and pain in exacerbation of arthritis, arthrosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Naproxen. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Naproxen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Naproxen in the presence of existing structural analogues.Use to treat inflammation and pain during exacerbation of arthritis, arthrosis, gout in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Naproxen - non-steroidal anti-inflammatory drug (NSAID), a derivative of naphthylpropionic acid. Has anti-inflammatory, analgesic and antipyretic effect.

The mechanism of action is associated with inhibition of the enzyme COX, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid.

Suppresses the aggregation of platelets.

Reduces pain syndrome, incl. pain in the joints at rest and during movement, morning stiffness and swelling of the joints, contributes to an increase in the volume of movements. The anti-inflammatory effect comes to the end of the 1st week of treatment.

Composition

Naproxen + auxiliary substances.

Pharmacokinetics

After ingestion naproxen is rapidly absorbed from the digestive tract. Food slows the rate of absorption, but does not reduce the degree of absorption. Naproxen is well absorbed by rectal administration, but absorption is slower than when ingested.

In therapeutic concentrations, naproxen binds to plasma proteins by more than 99%.The concentration of naproxen in the plasma increases proportionally at doses up to 500 mg, at higher doses an increase in clearance due to saturation of plasma proteins is observed.

Naproxen diffuses into the synovial fluid.

Approximately 95% of the dose is excreted in the urine as unchanged substance and 6-O-desmethylnaproxen and its conjugates. Less than 5% is administered with feces.

Indications

• rheumatoid arthritis;
• arthrosis or osteoarthritis;
• ankylosing spondylitis;
• articular syndrome with exacerbation of gout;
• pain in the spine;
• neuralgia;
• myalgia;
• traumatic inflammation of soft tissues and musculoskeletal system;
• with infectious and inflammatory diseases of ENT organs, adnexitis, primary dysmenorrhea, headache and toothache.

Forms of release

Tablets 250 mg and 500 mg.

Emulsion gel.

Ointment (sometimes mistakenly called cream).

Suspension for children.

Candles rectal.

Instructions for use and dosing regimen

Established individually taking into account the severity of the course of the disease.

Inside adults - 0.5-1 g per day in 2 divided doses. The daily dose for maintenance treatment is 500 mg.

The maximum daily dose is 1.75 g.

Gel or ointment is applied externally, and applied to the places in which there are painful sensations. The gel or ointment is gently rubbed into the skin in the affected area. Manipulation is repeated 4 to 5 times a day.

Rectal suppositories with Naproxenum are injected into the rectum once a night.

Children aged 1 to 5 years - 2.5-5 mg / kg per day in 1-3 admission, the maximum course of treatment is 14 days. With juvenile arthritis in children older than 5 years, the daily dose is 10 mg / kg.

Side effect

• nausea, vomiting;
• a feeling of discomfort in the epigastrium;
• erosive and ulcerative lesions of the gastrointestinal tract;
• bleeding and perforation of the gastrointestinal tract;
• impaired liver function;
• headache;
• drowsiness;
• slowing the speed of psychomotor reactions;
• hearing impairment;
• Thrombocytopenia, granulocytopenia, aplastic anemia, hemolytic anemia;
• eosinophilic pneumonia;
• impaired renal function;
• skin rash;
• hives;
• angioedema;
• when rectal administration - the appearance of mucous discharge with an admixture of blood, a painful defecation.

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
• aspirin triad;
• disorders of hematopoiesis;
• severe renal dysfunction (CC less than 20 ml / min);
• severe liver dysfunction;
• children under 1 year;
• hypersensitivity to naproxen and other NSAIDs.

Application in pregnancy and lactation

Use with caution in pregnancy (especially in 1 and 3 trimesters) and during lactation.

Naproxen penetrates through the placental barrier, excreted in breast milk in small amounts.

Use in children

Contraindicated in children under 1 year.

special instructions

With caution apply for liver and kidney disease, gastrointestinal diseases in history, with dyspeptic symptoms, with arterial hypertension, heart failure, immediately after serious surgical interventions.

In the process of treatment, systematic monitoring of liver and kidney function, a picture of peripheral blood is necessary.

If it is necessary to determine the concentration of 17-ketosteroids, naproxen should be discontinued 48 hours before the study.

Impact on the ability to drive vehicles and manage mechanisms

During the period of application, it is necessary to refrain from potentially dangerous activities related to the need for concentration of attention and increased speed of psychomotor reactions.

Drug Interactions

With simultaneous use with antacids containing magnesium and aluminum, sodium bicarbonate, the absorption of naproxen decreases.

With simultaneous use with indirect anticoagulants, cases of slight enhancement of the effect of anticoagulants are described.

With simultaneous use with amoxicillin, a case of developing a nephrotic syndrome is described; with Acetylsalicylic acid - it is possible to reduce the concentration of naproxen in the blood plasma.

With simultaneous application, it is possible to change the pharmacokinetic parameters of diazepam; with Caffeine - the effect of naproxen is enhanced; with lithium carbonate - it is possible to increase the concentration of lithium in blood plasma; with Methotrexate - may increase the toxicity of methotrexate.

There are reports of the development of myoclonus when used simultaneously with morphine.

With simultaneous use with prednisolone, a significant increase in the concentration of Prednisolone in the blood plasma is possible; with probenecid - a decrease in the concentration of naproxen in the blood plasma; with salicylamide - increases the effect of salicylamide.

With simultaneous application with furosemide, a decrease in the diuretic effect of Furosemide is possible.

Analogues of the drug Naproxen

Structural analogs for the active substance:

• Ultrazir Ultra;
• Aliv;
• Apranaks;
• Vimovo;
• Nalgezin;
• Nalgezin forte;
• Naprios;
• Naprobeene;
• Naproxen Acry;
• Naproxen sodium;
• Pentalgin H;
• Pronaxen;
• Sanaprox.

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