Menopur - instructions for use, reviews, analogs and forms of release (injections in ampoules for injection 75 IU, Multidoz 600 IU, 1200 IU) of a drug for infertility, polycystic ovary in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Menopur. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Menopur in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Menopur in the presence of existing structural analogues.Use for the treatment of infertility and the conduct of IVF protocols, polycystic ovaries in men and women, as well as during pregnancy and lactation. Composition of the hormonal drug.

Menopur - a preparation of human menopausal gonadotropin (hMG), a high degree of purification. Refers to the group of menotropins, contains follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in a ratio of 1: 1. The drug is obtained from urine in postmenopausal women.

In women, the drug causes an increase in the level of estrogens in the blood and stimulates the growth and maturation of ovarian follicles, endometrial proliferation.

In men, the use of Menopur leads to an increase in the concentration of testosterone in the blood and stimulates spermatogenesis, affecting Sertoli cells of the seminiferous tubules.

Composition

Follicle-stimulating hormone + Luteinizing hormone + auxiliary substances.

Pharmacokinetics

Cmax FSH in the blood plasma is achieved 6-24 hours after the / m administration of the drug Menopur. After that, the concentration of FSH in the blood gradually decreases. The half-life of menotropins is 4-12 hours.

Indications

For women:

• infertility caused by hypothalamic-pituitary disorders (to stimulate the growth of one dominant follicle);
• when conducting assisted reproductive techniques for the onset of conception (stimulation of the growth of multiple follicles).

For men:

• stimulation of spermatogenesis in azoospermia or oligoastenospermia caused by primary or secondary hypogonadotropic hypogonadism (in combination with therapy with human chorionic gonadotropin preparations, for example, with the Horagon drug).

Forms of release

Lyophilizate for solution for injection (injections in ampoules) 75 IU.

Lyophilizate for the preparation of a solution for intramuscular and subcutaneous administration of 600 IU and 1200 IU (Menopur Multidose).

Instructions for use and dosing regimen

The drug is administered intramuscularly or subcutaneously, usually in the abdomen or shoulder. The injection solution is prepared immediately prior to administration using the supplied solvent.

Women

Infertility due to hypothalamic-pituitary disorders, in order to stimulate the growth of one dominant follicle

Dosage regimen is set individually. The optimum dose of the drug and the duration of treatment are selected on the basis of ultrasound of the ovaries, determining the level of estrogens in the blood, as well as clinical observation.The maturation of the follicle is judged by the increase in the level of estrogens in the blood.

The initial dose of Menopur is 75-150 IU (1-2 vials a day). In the absence of ovarian response, the dose is gradually increased until the level of estrogen in the blood increases or the follicles grow. The dose is left unchanged until the time when the estrogen concentration reaches the preovulatory level. With a rapid rise in the level of estrogen at the beginning of stimulation, the dose of the drug should be reduced.

In order to induce ovulation 1-2 days after the last injection of Menopur, 5,000-10,000 IU hCG are administered once.

Men

For the purpose of stimulation of spermatogenesis, 1 000-3 000 IU hCG is administered 3 times a week before the normalization of testosterone level in the blood. Then, for several months, 3 times a week, Menopur is administered 75-150 IU (1-2 vials).

Side effect

• mastalgia;
• a sharp increase in the excretion of estrogen in the urine;
• moderately expressed (uncomplicated) ovarian enlargement;
• formation of ovarian cysts;
• in men - gynecomastia;
• nausea, vomiting;
• colicky pains;
• redness, swelling, itching at the injection site;
• arthralgia;
• reactions of hypersensitivity (incl.skin rash, fever);
• very rarely with prolonged use of the drug - the formation of antibodies (which leads to a decrease in the effectiveness of the therapy);
• oliguria;
• a decrease in blood pressure;
• weight gain;
• multiple pregnancy.

Ovarian hyperstimulation syndrome: early signs - pronounced abdominal pain, nausea, vomiting, weight gain; hypovolemia, an increase in the number of erythrocytes in the plasma (associated with a decrease in the volume of plasma), a violation of electrolyte balance, ascites, hemoperitoneum (the presence of blood in the abdominal cavity), hydrothorax, thromboembolic syndrome.

Contraindications

• diseases of the thyroid gland and adrenal glands;
• tumors of the hypothalamic-pituitary region;
• hyperprolactinemia;
• persistent ovarian enlargement or cysts not associated with polycystic ovary syndrome;
• anomalies in the development of genital organs or uterine fibroids, incompatible with pregnancy;
• vaginal bleeding of unclear etiology;
• cancer of the uterus, ovaries or mammary glands;
• primary failure of the ovaries;
• prostate cancer or other androgen-dependent tumors in men;
• pregnancy;
• lactation period;
• increased sensitivity to menotropins (drugs containing LH and / or FSH) and other components of the drug.

Application in pregnancy and lactation

Menopur is contraindicated in pregnancy and lactation.

In pregnancy, the manifestations of ovarian hyperstimulation syndrome worsen, their duration increases, this condition can lead to a threat to the life of the patient.

Use in children

Not used.

special instructions

Before the appointment of the drug Menopur recommended appropriate treatment in the presence of concomitant hypothyroidism, adrenocortical insufficiency, hyperprolactinaemia, tumors of the hypothalamic-pituitary region, correction of hemoconcentration.

Before the treatment of infertility should be evaluated the status of the ovaries (ultrasound and the level of estradiol in the blood plasma). During the course of treatment, these studies should be conducted daily or every other day.

It should be taken into account that against the background of the use of hMG drugs, the development of ovarian hyperstimulation is possible, which becomes clinically pronounced after the administration for the ovulation of hCG preparations and is manifested in the formation of large ovarian cysts.In this case, ascites, hydrothorax, accompanied by oliguria, arterial hypotension and thromboembolic syndrome may occur.

At the appearance of the first signs of ovarian hyperstimulation (abdominal pain, palpable or ultrasound-induced formation in the lower abdomen), treatment should be stopped immediately!

In the case of development of ovarian hyperstimulation, the preparation of hCG should not be administered for the purpose of ovulation.

When treating with hMG drugs, multiple pregnancy often develops.

In men with a high level of FSH in the blood (indicating a primary testicular failure), menopur is usually ineffective.

Drug Interactions

Menopur can be used in combination with the drug Horagon (human chorionic gonadotropin) in women - to induce ovulation, after stimulating the growth of follicles; in men - to stimulate spermatogenesis.

Analogues of the medicine Menopur

Structural analogs for the active substance:

• Gonadotropin is menopausal;
• Menogon;
• Menopur Multidose;
• The Merial;
• Pergonal;
• Humegon;
• HuMoG.

Analogues on the curative effect (agents for the treatment of polycystic ovary syndrome):

• Bromocriptine Richter;
• Gonal F;
• Clomiphene;
• Clostilbite;
• Puregon.

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