Sulfanilamide - instructions for use, analogs, reviews and release forms (tablets 0.3 g and 0.5 g, powder, liniment 5%, ointment 10%) drug for the treatment of sore throat, erysipelas, cystitis in adults, children and pregnancy . Composition

In this article, you can read the instructions for using the drug Sulfanilamide. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Sulfanilamide in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Sulfanilamide in the presence of existing structural analogs. Use to treat sore throat, erysipelas,cystitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Sulfanilamide - antibacterial agent of a wide spectrum of action. Sulfanilamide (streptocid) - one of the first representatives of chemotherapeutic agents of the sulfonamide group. Has a bacteriostatic effect. The mechanism of action is due to competitive antagonism with PABA and competitive inhibition of the enzyme dihydropteroate synthetase. This leads to a disruption in the synthesis of dihydrofolic and then tetrahydrofolic acid and, as a result, a violation of the synthesis of nucleic acids.

Sulfanilamide is active against Gram-positive and Gram-negative cocci, Escherichia coli (E. coli), Shigella spp. (shigella), Vibrio cholerae, Haemophilus influenzae, Clostridium spp., Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, and also against Chlamydia spp. (chlamydia), Actinomyces spp., Toxoplasma gondii (toxoplasm).

With topical application promotes rapid healing of wounds.

In the past, sulfanilamide was used internally to treat sore throat, erysipelas, cystitis, pyelitis, enterocolitis, prevention and treatment of wound infection. Sulfanilamide (Streptocid soluble) in the past was used as a 5% aqueous solution for intravenous administration.

It is not an antibiotic.

Composition

Sulfanilamide + auxiliary substances.

Pharmacokinetics

When ingested quickly absorbed from the digestive tract. Cmax in the blood is created after 1-2 hours and is reduced by 50% usually in less than 8 hours. Passes through the histohematological, including the blood-brain barrier (GEB), placental barriers. It is distributed on tissues, after 4 hours it is found in cerebrospinal fluid. In the liver, acetylated with a loss of antibacterial properties. It is excreted mainly (90-95%) by the kidneys.

Information on the carcinogenic, mutagenic effect and the effect on fertility with prolonged use in animals and humans is absent.

Indications

• tonsillitis (tonsillitis);
• sinusitis (sinusitis);
• bronchitis;
• pneumonia;
• purulent-inflammatory skin lesions (skin abscess);
• infected wounds of various etiologies (including ulcers, cracks);
• furuncle;
• carbuncle;
• pyoderma;
• folliculitis;
• face;
• Acne vulgaris;
• impetigo;
• acute and chronic cholecystitis;
• cholangitis;
• cystitis;
• urethritis and urethral syndrome;
• inflammatory diseases of the prostate (prostatitis);
• salpingitis and oophoritis;
• burns (1 and 2 degrees).

Forms of release

Tablets 0.3 g and 0.5 g.

Powder for outdoor use 2 g and 5 g.

Liniment 5%.

Ointment 10%.

Instructions for use and how to use them

Inside - for 0.5 g 5-6 times a day; children under 1 year - 0.05-0.1 g per reception, 2-5 years - 0.2-0.3 g, 6-12 years - 0.3-0.5 g.

When deep wounds are injected into the cavity of the wound in the form of a carefully crushed sterilized powder (5-15 g), while prescribing antibacterial drugs inside.

When applied externally, they are applied to the affected areas of the skin and mucous membranes.

Maximum doses for adults with oral administration: single 2 g, daily - 7 g.

Side effect

• nausea, vomiting;
• diarrhea;
• eosinophilia, thrombocytopenia, leukopenia, hypoprothrombinemia, agranulocytosis;
• impaired vision;
• headache;
• dizziness;
• peripheral neuropathy;
• cyanosis;
• ataxia;
• skin allergic reactions;
• nephrotoxic reactions (most likely in patients with impaired renal function);
• hypothyroidism.

Contraindications

• severe renal insufficiency;
• blood diseases;
• deficiency of glucose-6-phosphate dehydrogenase;
• nephroses, nephritis;
• acute porphyria;
• thyrotoxicosis;
• 1 and 2 trimesters of pregnancy;
• lactation;
• hypersensitivity to sulfonamides.

Application in pregnancy and lactation

Sulfanilamide is contraindicated for use in the first and second trimester of pregnancy and lactation.

Use in children

Use in children is possible according to the dosing regimen.

special instructions

Use with caution in patients with impaired renal function. During the treatment period, it is necessary to increase the amount of fluid consumed.

When hypersensitivity reactions appear, treatment should be discontinued.

With prolonged treatment, systematic monitoring of the blood picture, kidney and liver function is recommended.

Drug Interactions

Not noted.

Analogues of the drug Sulfanilamide

Structural analogs for the active substance:

• Streptocide;
• Streptocide is soluble;
• Streptocide tablets;
• Streptocide Ointment 10%.

Analogues on the pharmacological group (sulfonamides):

• Arhedin;
• Argosulfan;
• Bactrim;
• Bactrim forte;
• Biseptol;
• Grosseptol;
• Dvseptol;
• Dermazin;
• Inhaliptus;
• Co-trimoxazole;
• Cotripharm 480;
• Lidaprim;
• Mafenide acetate ointment 10%;
• Methosulfabol;
• Oriprim;
• Septrin;
• Sinersul;
• Streptonitol;
• Streptocide;
• Sulotrim;
• Sulgin;
• Sulphadimezine;
• Sulfadimethoxin;
• Sulfalene;
• Sulfamethoxazole;
• Sulfargin;
• Sulfasalazine;
• Sulfatiazole sodium;
• Sulfacetamide;
• Sulfacil sodium;
• Sumetrolim;
• Trimezol;
• Phthalazole;
• Phthalylsulfatiazole;
• Tsiplin;
• Ethazol.

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