5 NOC - instructions for use, analogs, reviews and release forms (tablets 50 mg) drugs for the treatment of cystitis, pyelonephritis and other urinary tract infections in adults, children and in pregnancy

In this article, you can read the instructions for using the drug 5 NOCs. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of 5 nok in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues 5 nok in the presence of existing structural analogues. Use for the treatment of cystitis, pyelonephritis and other infections of the urinary tract in adults, children, as well as during pregnancy and lactation.

5 NOCs - antimicrobial preparation, derivative of 8-hydroxyquinoline.

Has a wide range of action. Selectively inhibits the synthesis of bacterial DNA, forms complexes with metal-containing enzymes of the microbial cell.

It is active against Gram-positive and Gram-negative bacteria, as well as other microorganisms: Ureaplasma urealyticum, Mycoplasma hominis, Mycobacterium tuberculosis, Trichomonas vaginalis. Effective against some species of fungi (candida, dermatophytes, mold fungi, some pathogens of deep mycoses).

Pharmacokinetics

Nitroxoline is well absorbed from the digestive tract (90%). Metabolised in the liver. It is excreted mainly by the kidneys in unchanged form and partly with bile. There is a high concentration of conjugated and unconjugated drug in the urine.

Indications

Treatment of acute, chronic and recurrent urinary tract infections caused by micro-organisms sensitive to nitroxoline:

• pyelonephritis;
• cystitis;
• urethritis;
• epididymitis;
• infected adenoma or carcinoma of the prostate.

Preventive maintenance of infectious complications in the postoperative period at surgical interventions on kidneys and genitourinary ways,as well as with diagnostic and therapeutic manipulations (catheterization, cystoscopy).

Prevention of recurrent urinary tract infections.

Forms of release

The tablets covered with a cover of 50 mg.

Instructions for use and dosing regimen

The standard dose for adults and adolescents is 400 mg per day, divided into 4 divided doses (2 tablets 4 times a day). The maximum dose is 800 mg per day.

The average dose for children older than 5 years is 200-400 mg per day, divided into 4 doses; for children 3-5 years - 200 mg per day, divided into 4 doses.

The course of treatment is 2-4 weeks, if necessary, therapy is continued with intermittent courses (2 weeks for a month).

Patients with moderate renal insufficiency (KC more than 20 ml / min) and liver failure are recommended to use half the standard daily dose of the drug - 200 mg per day (1 tablet 4 times a day).

Tablets should be taken before meals.

Side effect

• nausea, vomiting (can be prevented by taking the drug while eating);
• ataxia;
• headache;
• paresthesia, polyneuropathy;
• tachycardia;
• skin rash;
• thrombocytopenia.

Contraindications

• cataract;
• renal failure of severe degree (CC less than 20 ml / min);
• severe hepatic impairment;
• children under 3 years;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to nitroxoline or other components of the drug;
• hypersensitivity to quinolines.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

Use in children

5 NOC is contraindicated in children under 3 years of age.

special instructions

Nitroxoline should not be administered simultaneously with drugs containing hydroxyquinolines or their derivatives.

Do not prescribe treatment courses for more than 4 weeks without additional examination of the liver and kidney function.

Against the background of treatment with nitroxoline, urine is colored in an intense yellow-red color.

Impact on the ability to drive vehicles and manage mechanisms

There is no data on the effect on the ability to drive or operate machinery.

Drug analogues 5 NOCs

Structural analogs for the active substance:

• 5-Nitrox
• Nitroxoline
• Nitroxoline-ACOS
• Nitroxoline-UBF

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