Nitroxoline - instructions for use, reviews, analogs and formulations (tablets 50 mg) of the drug for the treatment of cystitis, pyelonephritis and urethritis in adults, children and pregnancy
In this article, you can read the instructions for using the drug Nitroxoline. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Nitroxoline in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Nitroxoline in the presence of existing structural analogs. Use for the treatment of cystitis, pyelonephritis and urethritis in adults, children, as well as during pregnancy and lactation.
Nitroxoline - antimicrobial agent, derivative of 8-hydroxyquinoline. The mechanism of action is associated with selective inhibition of the synthesis of bacterial DNA.
Nitroxoline is active against gram-positive and gram-negative bacteria.
Nitroxoline is also active against Mycobacterium tuberculosis, Trichomonas vaginalis, certain species of fungi (Candida spp., Dermatophytes, molds, some pathogens of deep mycoses).
Pharmacokinetics
After oral administration, it is highly absorbed from the digestive tract.
It is excreted by the kidneys unchanged. Urine has high concentrations of nitroxoline.
Indications
- Infectious and inflammatory diseases predominantly of the genitourinary tract (including pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or carcinoma of the prostate gland) caused by micro-organisms sensitive to nitroxoline;
- preventive maintenance of infectious complications at diagnostic and medical manipulations (a catheterization, a cystoscopy) in the postoperative period at surgical interventions on kidneys and urinogenital ways.
Forms of release
Tablets 50 mg.
Instructions for use and dosage
For adults, the dose is 600-800 mg per day.Multiplicity of admission - 3-4 times a day with an interval of 6-8 hours. The course of treatment - 10-14 days.
The maximum daily dose is 1-1.2 g.
For children, the dose is 10-30 mg / kg per day in 3-4 divided doses.
With chronic recurrent processes, the course of treatment is several months.
Side effect
- nausea, vomiting;
- loss of appetite;
- impaired liver function;
- skin rash;
- itching;
- ataxia;
- headache;
- paresthesia;
- polyneuropathy;
- neuritis of the optic nerve;
- tachycardia.
Contraindications
- disorders of kidney function, accompanied by oligo- or anuria;
- severe liver disease;
- deficiency of glucose-6-phosphate dehydrogenase;
- cataract;
- neuritis;
- pregnancy;
- lactation;
- hypersensitivity to quinoline preparations.
Application in pregnancy and lactation
Nitroxoline is contraindicated in pregnancy and lactation (breastfeeding).
Use in children
The application is possible according to the dosing regimen.
special instructions
Against the background of Nitroxolin, urine is colored saffron-yellow.
Caution is prescribed for renal failure (cumulation is possible).
Drug Interactions
Drug interaction of the drug Nitroxoline is not described.
Analogs of the drug Nitroxoline
Structural analogs for the active substance:
- 5 Nitrox;
- 5 NOCs;
- Nitroxoline of Acos;
- Nitroxoline UBF.
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