Dioxydin - instructions for use, analogs, reviews and release forms (solution in ampoules for inhalation and topical use (in the nose) 0.5% and 1%, ointment 5%) of the drug for the treatment of sinusitis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Dioxydin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Dioxydin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Dioxydin in the presence of existing structural analogs.Use for the treatment of wounds and ulcers, sinusitis and furuncles, as well as inhalations in adults, children, as well as during pregnancy and breast-feeding.

Dioxydin - a broad-spectrum antibacterial drug from the group of quinoxaline derivatives, has chemotherapeutic activity in infections caused by vulgar proteus, dysentery rod, Klebsiella, Pseudomonas aeruginosa, salmonella, staphylococcus, streptococcus, pathogenic anaerobes (including agents of gas gangrene), acts on strains of bacteria resistant to other chemotherapeutics, including antibiotics.

Possible development of drug resistance of bacteria. At intravenous introduction is characterized by small therapeutic breadth, in this connection strict observance of recommended doses is necessary. Treatment of burns and purulent-necrotic wounds promotes faster cleaning of the wound surface, stimulates reparative regeneration and marginal epithelization and favorably influences the course of the wound process.

Pharmacokinetics

When topical application is partially absorbed from the wound or burn surface, it is excreted by the kidneys.

Indications

• suppurative bacterial infections caused by sensitive microflora when other chemotherapeutic agents are ineffective or poorly tolerated.

External application

• superficial and deep wounds of different localization;
• long-term non-healing wounds and trophic ulcers;
• phlegmon soft tissue;
• infected burns;
• purulent wounds in osteomyelitis.

Intracavernal administration

• suppurative processes in the thoracic and abdominal cavities;
• with purulent pleurisy, empyema of the pleura, lung abscess, peritonitis, cystitis, wounds with the presence of deep purulent cavities (abscesses of soft tissues, phlegmon of the pelvic fat, postoperative wounds of the urinary and bile ducts, purulent mastitis).

Forms of release

Solution in ampoules for inhalation and local, as well as intracavitary use (in the nose) 5 mg / ml and 1%.

Ointment for external use 5%.

Solution for intravenous administration 0.5%.

Instructions for use and use diagrams

Dioxydin is prescribed in a hospital. Apply externally, intracavitary.

1% Dioxydin solution can not be used for intravenous administration, because of instability of the solution when stored at low temperatures.

External application

Apply 0.1-1% solutions of Dioxydin.To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the desired concentration with a sterile isotonic sodium chloride solution or water for injection.

For the treatment of superficial infected purulent wounds, wipes moistened with 0.5-1% dioxygen solution are applied to the wound. Deep wounds after treatment, loose plugging with swabs moistened with 1% dioxygen solution, and in the presence of a drainage tube, 20 to 100 ml of 0.5% solution of the drug is injected into the cavity.

To treat deep purulent wounds in osteomyelitis (bruises of the wrist, feet) apply 0.5-1% solutions of the drug in the form of trays or special treatment of the wound with the solution of the drug for 15-20 minutes (insertion of the solution into the wound for this period), followed by bandaging with 1% solution of dioxidine.

Dioxydin in the form of 0.1-0.5% solutions can be used to prevent infection after surgery. According to the indications (patients with osteomyelitis) and with good tolerability treatment can be carried out daily for 1.5-2 months.

Intracavernal administration

In the purulent cavity, depending on its size, 10-50 ml of a 1% solution of dioxidine per day is administered.Dioksidina solution is injected into the cavity through a catheter, drainage tube or syringe.

The maximum daily dose for administration in a cavity of 70 ml of a 1% solution.

The drug is injected into the cavity usually 1 time per day. According to the indications, it is possible to administer a daily dose in two divided doses. With good tolerability and the presence of indications, the drug can be administered daily for 3 weeks or more. If necessary, repeat courses are conducted after 1-1.5 months.

Side effect

• headache;
• chills;
• temperature increase;
• dyspeptic disorders;
• convulsive muscle contractions;
• allergic reactions;
• photosensitizing effect (the appearance of pigmented spots on the body when exposed to sunlight);
• periarane dermatitis (with external application).

Contraindications

• adrenal insufficiency (including in the anamnesis);
• pregnancy;
• lactation period;
• childhood;
• hypersensitivity to dioxin.

Application in pregnancy and lactation

Contraindicated in pregnancy and lactation.

special instructions

Dioxydin is prescribed only to adults. Before the beginning of the course of treatment, a drug tolerance test is carried out, for which 10 ml of a 1% solution is injected into the cavity.If there are no side effects during 3-6 hours (dizziness, chills, fever), they begin course treatment.

Dioxydin is prescribed only with severe forms of infectious diseases or with the ineffectiveness of other antibacterial drugs, incl. cephalosporins 2-4 generations, fluoroquinolones, carbapenems.

In chronic renal failure, the dose is reduced.

When pigmented spots appear, the duration of administration of a single dose is increased to 1.5-2 hours, the dose is reduced, antihistamines are prescribed, or Dioxydin is canceled.

In the case of precipitation of Dioxydin crystals in ampoules with solution during storage (at a temperature below 15 ° C) they are dissolved by heating the ampoules in a boiling water bath with shaking until the crystals are completely dissolved (clear solution). If the crystals do not fall again upon cooling to 36-38 ° C, the preparation is usable.

Analogues of the drug Dioxydin

Structural analogs for the active substance:

• Hydroxymethyl-quinoxylindioxide;
• Dioxidept;
• Dioxin oxide;
• Urotavenol.

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