Meldonium - instructions for use, reviews, analogs and forms of release (capsules or tablets 250 mg and 500 mg, injections in ampoules) for the treatment of IHD, rehabilitation of athletes in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Meldoney. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Meldonia in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Meldonium in the presence of existing structural analogs. Use for the treatment of IHD, fatigue, recovery of athletes in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Meldoney - a remedy for metabolism, an analogue of gamma-butyrobetaine. It suppresses gamma-butyrobetaine hydroxynase, inhibits synthesis of Carnitine and transport of long chain fatty acids through cell membranes, prevents accumulation of activated forms of unoxidized fatty acids - acylcarnitine derivatives and acylcoenzyme A.

Under conditions of ischemia, it restores the equilibrium of the processes of oxygen delivery and its consumption in cells, prevents the violation of ATP transport; simultaneously, it activates glycolysis, which proceeds without additional consumption of oxygen. As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is synthesized intensively. The mechanism of action determines the variety of its pharmacological effects: increasing efficiency, reducing the symptoms of mental and physical overstrain, the activation of tissue and humoral immunity, cardioprotective action.

In the case of acute ischemic damage, the myocardium slows the formation of the necrotic zone, shortens the rehabilitation period.With heart failure increases myocardial contractility, increases exercise tolerance, reduces the incidence of angina attacks. In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes redistribution of blood in favor of the ischemic site. Effective in vascular and dystrophic pathology of the fundus. Has a tonic effect on the central nervous system, eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal syndrome.

Composition

Meldonia dihydrate (trimethylhydrazinium propionate dihydrate) + auxiliary substances.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the digestive tract. Bioavailability is about 78%. Cmax in plasma is achieved 1-2 hours after administration. Biotransformed in the body with the formation of two major metabolites, which are excreted by the kidneys.

Indications

For oral or intravenous administration:

• in the complex therapy of IHD (angina pectoris, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy;
• in the complex therapy of acute and chronic disorders of cerebral circulation (strokes and cerebrovascular insufficiency);
• reduced working capacity;
• physical overexertion (including athletes);
• Postoperative period to accelerate rehabilitation;
• syndrome of withdrawal from chronic alcoholism (in combination with specific therapy of alcoholism).

For parabulbar injection:

• acute circulatory disturbance in the retina;
• hemophthalmia and hemorrhage into the retina of various etiologies;
• thrombosis of the central vein of the retina and its branches;
• retinopathy of various etiology (including diabetic and hypertensive) - only for parabulbar injection.

Forms of release

Capsules 250 mg and 500 mg (sometimes mistakenly called pills).

Solution for parabulbar and intravenous administration (injections in ampoules for injections).

Instructions for use and dosage

In connection with the possibility of development of an exciting effect, use is recommended in the first half of the day. The dose is set individually depending on the indications and the route of administration.

When administered orally, a single dose is 0.25-1 g, the frequency of administration and the duration of treatment depend on the indications.

When administered intravenously, the dose is 0.5-1 g 1 time per day, the duration of treatment depends on the indications.

Parabulbarno injected into 0.5 ml of a solution for injection with a concentration of 500 mg / 5 ml for 10 days.

Athletes are prescribed for reconstructive therapy according to special schemes in combination with other means. Officially recognized as doping.

Side effect

• tachycardia;
• changes in blood pressure (arterial hypotension);
• psychomotor agitation;
• dyspeptic symptoms;
• itching;
• redness;
• rash;
• edema.

Contraindications

• increased intracranial pressure (including with violation of venous outflow, intracranial tumors);
• pregnancy;
• lactation period (breastfeeding);
• children and adolescents under 18;
• increased sensitivity to meldonia.

Application in pregnancy and lactation

During pregnancy and lactation (breast-feeding), the use of the drug Meldonium is contraindicated.

Use in children

In children and adolescents under the age of 18 years, the effectiveness and safety of milledonia is not established.

Meldonium in the form of capsules is contraindicated for use in children and adolescents under the age of 18; in the form of syrup - in children under 12 years of age.

special instructions

Use with caution in diseases of the liver and / or kidneys, especially for a long time.

Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiac units shows that meldonium is not a first-line agent in acute coronary syndrome.

Drug Interactions

With the joint application, Meldonium enhances the effect of antianginal drugs, some antihypertensive drugs, cardiac glycosides.

With the simultaneous use of Meldonium with nitroglycerin, nifedipine, alpha-adrenoblockers, antihypertensive agents and peripheral vasodilators, it is possible to develop moderate tachycardia, arterial hypotension (with these combinations caution is required).

Analogues of the drug Meldony

Structural analogs for the active substance:

• 3- (2,2,2-Trimethylhydrazinium) propionate dihydrate;
• Angiocardil;
• Vazomag;
• Idrinol;
• Cardion;
• Medatern;
• Meldonium Organica;
• Meldonius Binergia;
• Meldonius Eskom;
• Meldonium dihydrate;
• Melfor;
• Midolat;
• Mildronate.

Analogues on the curative effect (means for the treatment of physical, mental overload and rehabilitation):

• Additive with iron;
• Antioxidants with iodine;
• Asvitol;
• Ascovit;
• Berrocka Plus;
• Vazomag;
• Vazoton (L-arginine);
• Valeocorus Q10;
• Vitamax;
• Vitaspectrum;
• Vitatress;
• Vitrum Plus;
• Galavit;
• Hepargin;
• Heptolexin;
• Dibikor;
• Jériton;
• Duovit;
• Idrinol;
• Inosine;
• Beresz Plus drops;
• Cardion;
• Carnitine;
• Corilip;
• Coenzyme compositum;
• Cropanol;
• Kudevita;
• Qudesan;
• Lamivite;
• Leriton Active;
• Mexidol;
• Mexicor;
• Metaproth;
• Mildronate;
• Nagypol;
• Neoton;
• Oligovit;
• Pantogam;
• Pantokaltsin;
• Pikovitz;
• Pikovitz Fort;
• Riboxin;
• Ribonosine;
• Selmevit;
• Trekrezan;
• Triovit;
• Ubihinon compositum;
• Falcamin;
• Centrum;
• Cytoflavin;
• Cigapan;
• Eleutherococcus extract;
• Eltacin;
• Elkar;
• Encephabol;
• Yantavit.

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