Cardionate - instructions for use, analogs, reviews and release forms (capsules or tablets 250 mg and 500 mg, injections in injections) of the drug for the treatment of IHD, stroke, thrombosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Cardionate. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Cardion in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cardionate in the presence of existing structural analogues. Use for the treatment of coronary heart disease (CHD), stroke, thrombosis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Cardionate - a drug that improves the metabolism and energy supply of tissues, a synthetic analogue of gamma-butyrobetaine. It suppresses gamma-butyrobetaine hydroxynase. Reduces the synthesis of Carnitine and the transport of long chain fatty acids through cell membranes, prevents the accumulation of activated forms of unoxidized fatty acids - the derivatives of acylcarnitine and acylcoenzyme A in cells. Under conditions of ischemia, it restores the equilibrium of the processes of oxygen delivery and its consumption in cells, prevents the violation of ATP transport. Simultaneously, it activates glycolysis, which proceeds without additional consumption of oxygen. As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is synthesized intensively.

The mechanism of action determines the variety of pharmacological effects of the drug: increasing efficiency, reducing the symptoms of mental and physical overstrain, the activation of tissue and humoral immunity, cardioprotective action.

In the case of acute ischemic damage, the myocardium slows the formation of the necrotic zone, shortens the rehabilitation period.

With heart failure increases myocardial contractility, increases exercise tolerance, reduces the incidence of angina attacks.

In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes redistribution of blood in favor of the ischemic site.

Effective in the case of vascular and dystrophic pathology of the fundus.

It is also characteristic tonic effect on the central nervous system, the elimination of functional disorders of somatic and autonomic nervous systems in patients with chronic alcoholism with withdrawal syndrome.

Composition

Meldonium dihydrate + auxiliary substances.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the digestive tract. Bioavailability is 78%. Metabolized in the body with the formation of two major metabolites, which are excreted by the kidneys.

Indications

• reduced working capacity;
• increased physical activity;
• Postoperative period to accelerate rehabilitation;
• in the combined therapy of IHD, chronic heart failure, cardialgia against the background of dyshormonal myocardial dystrophy;
• complex therapy of withdrawal alcohol syndrome;
• acute and chronic forms of cerebral circulation disorders (stroke, cerebrovascular insufficiency);
• acute disturbance of blood circulation in the retina, hemophthalmia and hemorrhage into the retina of various etiologies;
• thrombosis of the central vein of the retina and its branches;
• retinopathy of various etiology (including diabetic and hypertensive) - only for parabulbar injection.

Forms of release

Capsules 250 mg and 500 mg (sometimes mistakenly called pills).

Solution for injections (injections in ampoules).

Instructions for use and dosage

Capsules

In view of the possible development of an exciting effect, it is recommended to apply in the morning.

With a decrease in working capacity and physical overstrain (including athletes), it is prescribed by mouth 250 mg 4 times a day. The course of treatment is 10-14 days. If necessary, the treatment is repeated after 2-3 weeks.

Athletes are appointed inside by 0.5-1 g 2 times a day before training. The duration of the course in the preparatory period is 14-21 days, during the competition - 10-14 days.

With stable angina, 250 mg are administered 3 times a day during the first 3-4 days, then 250 mg three times a day 2 times a week.

With cardialgia against the background of dyshormonal myocardial dystrophy, 250 mg twice a day (morning and evening). The course of treatment is 12 days.

With chronic alcoholism - 500 mg 4 times a day. The course of treatment is 7-10 days.

For chronic disorders of cerebral circulation - 0.5-1 g per day, preferably in the morning. The course of treatment is 2-3 weeks.

Capsules swallow whole, washed down with water.

Ampoules

Increased mental and physical activity: intravenously, 1 g (10 ml) 1 time per day. The course of treatment is 10-14 days. If necessary, repeat the course after 2-3 weeks.

In cardiovascular diseases (as part of complex therapy): iv 0.5-1 g (5-10 ml); course of treatment - 10-14 days.

Violation of cerebral circulation: acute phase - IV infusion of 500 mg (5 ml) once a day for 7-10 days, then switch to oral administration.

Chronic insufficiency of cerebral circulation: intramuscularly 500 mg (5 ml) once a day. The course of treatment - 10-14 days, then go to the reception inside.

Chronic alcoholism: in / in - 500 mg (5 ml) 2 times a day. The course of treatment is 7-10 days.

Vascular pathology of the fundus and dystrophy of the retina: retrobulbarno and subconjunctivally injected 50 mg (0.5 ml solution for injection) for 10 days.

Side effect

• tachycardia;
• a decrease in blood pressure;
• redness, rashes;
• itching;
• edema;
• dyspepsia;
• excitation.

Contraindications

• increased intracranial pressure (with violation of venous outflow, intracranial tumors);
• age under 18 years (effectiveness and safety not established);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The safety of the drug during pregnancy is not proven. To avoid possible adverse effects on the fetus, Cardionate should not be administered during pregnancy.

It is not known whether a drug with human milk is excreted in humans. If you need to use the drug during lactation, breastfeeding should be discontinued.

Use in children

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).

special instructions

Cardiotion is not a first-line drug in acute coronary syndrome and its use is not an urgent need.

With caution apply the drug for a long time in patients with chronic liver and kidney diseases.

Impact on the ability to drive vehicles and manage mechanisms

There is no evidence of adverse effects of the drug on the rate of psychomotor reactions.

Drug Interactions

Strengthens the action of coronary dilatation drugs, some hypotensive drugs, cardiac glycosides.

You can combine with antianginal drugs, anticoagulants and antiaggregants, antiarrhythmics, diuretics, bronchodilators.

In view of the possible development of moderate tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-adrenoblockers, antihypertensive agents and peripheral vasodilators.

Analogues of the medicinal product Cardionate

Structural analogs for the active substance:

• Angiocardil;
• Vazomag;
• Idrinol;
• Medatern;
• Meldonius;
• Meldonium dihydrate;
• Melfor;
• Midolat;
• Mildronate;
• Trimethylhydrazinium propionate dihydrate.

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