Oxacillin - instructions for use, reviews, analogues and forms of release (injections in ampoules for antibiotic injections, tablets of 250 mg) of the drug for the treatment of bronchitis, pneumonia, sinusitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Oxacillin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of the antibiotic Oxacillin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Oxacillin in the presence of existing structural analogues.Use for the treatment of bronchitis, pneumonia, sinusitis and other infectious diseases in adults, children (including babies and newborns), as well as during pregnancy and lactation. Composition of the preparation.

Oxacillin - an antibiotic of a group of semisynthetic penicillins. Has a bactericidal effect, suppressing the synthesis of the bacterial cell wall.

It is active against gram-positive bacteria: Staphylococcus spp. (staphylococcus) (including strains producing penicillinase), Streptococcus spp. (streptococcus) (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic spore-forming rods, some strains of Actinomyces spp.

Not active against most Gram-negative bacteria, rickettsia, viruses, protozoa, fungi.

In connection with acid resistance, it is effective for oral administration.

Resistant to the action of penicillinase.

Composition

Oxacillin (in the form of sodium salt) + auxiliary substances.

Pharmacokinetics

After oral administration, it is quickly and completely absorbed from the digestive tract. It is stable in slightly acidic medium. The intake of food reduces the absorption of oxacillin. Binding to plasma proteins is 93%. With parenteral administration, higher concentrations are achieved in the blood than when ingested.In the pleural fluid is found in a concentration reaching 10%, synovial and ascitic fluid - 50%, bile - 5-8% in relation to its concentration in the blood serum. Does not penetrate the intact blood-brain barrier (BBB), with inflammation of meningeal membranes, penetration increases. Penetrates through the placental barrier, is found in breast milk. About 20-30% after ingestion and more than 40% after intramuscular injection is rapidly excreted in the urine. Oxacillin is also excreted with bile.

Indications

Infectious diseases caused by gram-positive microorganisms that produce and do not produce penicillinase:

• sepsis;
• abscess;
• phlegmon;
• cholecystitis;
• pyelitis;
• cystitis;
• osteomyelitis;
• postoperative, wound infections, infected burns;
• bacterial endocarditis;
• meningitis;
• sinusitis.

Forms of release

Powder for the preparation of solution for intravenous and intramuscular injection (injections in ampoules for injection).

Tablets 250 mg.

Other dosage forms, be it ointment, cream or eye drops, do not exist.

Instructions for use and dosage

Adults and children over 6 years of age - 2-4 grams per day.

Children under the age of 3 months - 60-80 mg / kg per day, from 3 months to 2 years - 1 g per day, from 2 to 6 years - 2 g per day.

Newborn and premature children - 20-40 mg / kg per day.

Multiplicity of administration - 4 times a day (every 4-6 hours). The duration of treatment is usually 7-10 days. In severe forms of the disease (sepsis, septic endocarditis) treatment can last for 2-3 weeks or more.

When preparing solutions for intramuscular injections, a 1.5 ml bottle is added to a 250 mg vial, with 500 mg - 3 ml of water for injection.

When preparing solutions intended for intravenous fluid administration, 250 mg or 500 mg is dissolved in 5 ml of water for injection or 0.9% solution of sodium chloride and injected slowly, for 5-10 minutes.

For intravenous drip (in the form of a dropper) of oxacillin, the sodium salt is dissolved in a 0.9% solution of sodium chloride or in a 5% solution of Dextrose to a concentration of 0.5-2 mg / ml and injected for 1-2 hours at a rate of 60-100 drops / min.

Side effect

• nausea, vomiting;
• diarrhea;
• abnormal liver function;
• increased activity of hepatic transaminases;
• itching;
• hives;
• angioedema;
• bronchospasm;
• anaphylactic shock;
• eosinophilia;
• hematuria (blood in the urine);
• proteinuria;
• interstitial nephritis;
• Candidiasis of the oral cavity;
• pseudomembranous colitis;
• vaginal candidiasis;
• thrombophlebitis (with intravenous administration).

Contraindications

• hypersensitivity to oxacillin and other penicillins.

Application in pregnancy and lactation

The use of oxacillin in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

Use in children

The use is possible according to the dosing regimen (including infants and newborns).

special instructions

It should be used with caution in allergic reactions in history, bronchial asthma, chronic kidney failure, enterocolitis on the background of antibiotics (in the anamnesis).

Drug Interactions

With simultaneous use with tetracyclines, there is a decrease in the bactericidal action of oxacillin.

The combination of ampicillin or benzylpenicillin with oxacillin is rational, because the latter, suppressing the activity of penicillinase, reduces thereby the destruction of ampicillin and benzylpenicillin. The spectrum of action with this combination becomes wider.

Antacids and laxatives reduce the absorption of oxacillin from the digestive tract.

It is not recommended to prescribe oxacillin simultaneously with bacteriostatic antibiotics (decreased efficiency).

Drugs that block tubular secretion, increase the concentration of oxacillin in the blood.

Oxacillin increases the toxicity of Methotrexate (competition for tubular secretion).

With simultaneous use, it may be necessary to increase the doses of calcium folinate (antidote for antagonists of folic acid) and its longer use.

It is necessary to avoid joint use with other drugs that have a hepatotoxic effect.

Analogues of the drug Oxacillin

Structural analogs for the active substance:

• Ampioks;
• Oxamp;
• Oksamsar;
• Oxacillin sodium salt;
• Oxacillin sodium tablets;
• Prostaflin.

Analogues on the pharmacological group (antibiotics penicillins):

• Amoxiclav;
• Amoxisar;
• Amoxicillin;
• Amoxicillin + Clavulanic acid;
• Amoxicillin trihydrate;
• Amosin;
• Ampioks;
• Ammisid;
• Ampicillin;
• Ampicillin trihydrate;
• Augmentin;
• Benzylpenicillin;
• Betaclav;
• Bicillin 1;
• Bicillin 3;
• Bicillin 5;
• Vepicombin;
• Grunamox;
• Danemox;
• Zetsil;
• Carbenicillin;
• Clamosar;
• Cloxacillin;
• Maripen;
• Megacillin screamed;
• Médoclase;
• Oxamp;
• Ospamox;
• Ospen;
• Panklav;
• Penicillin;
• Piperacillin + Tazobactam;
• Piprax;
• Picillin;
• Procaine Benzylpenicillin;
• Ranklav;
• Rapiklav;
• Retarpen;
• Santa's;
• Sultasin;
• Tazocine;
• Taromentine;
• Timentin;
• Trifamox;
• Unazine;
• Phenoxymethylpenicillin;
• Fibell;
• Flemoclav Solutab;
• Flemoxin Solutab;
• Flukloxacillin;
• Foraklav;
• Helithrix;
• Hiconcile;
• Ecobol;
• Ecoclave;
• Extensillin.

Similar medicines:

Other medicines: