Desloratadine - instructions for use, reviews, analogs and formulations (5 mg tablets) of an antihistamine drug for the treatment of rhinitis or rhinitis, urticaria and other manifestations of allergies in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Desloratadine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Desloratadine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Desloratadine in the presence of existing structural analogues.Use for the treatment of allergic rhinitis or rhinitis, urticaria and other manifestations of allergy in adults, children, as well as during pregnancy and lactation. Composition of antihistamine drug.

Desloratadine - blocker of histamine H1-receptors (long-acting). It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents development and facilitates the course of allergic reactions. It has anti-allergic, antipruritic and antiexcudative action. Reduces the permeability of capillaries, prevents the development of edema of tissues, relieves spasm of smooth muscles. Virtually does not have a sedative effect and when taken in a dose of 7.5 mg does not affect the rate of psychomotor reactions. In comparative studies of desloratadine and loratadine, no qualitative or quantitative differences in the toxicity of the two drugs in comparable doses (taking into account the concentration of desloratadine) have not been revealed.

Composition

Desloratadine + auxiliary substances.

Pharmacokinetics

After oral administration, it begins to be detected in the plasma after 30 minutes. Food does not affect distribution.Bioavailability is proportional to the dose in the range of 5 mg to 20 mg. Binding to plasma proteins is 83-87%. After a single dose of 5 mg or 7.5 mg of Cmax is achieved after 2-6 hours (an average of 3 hours). Does not penetrate the blood-brain barrier (BBB). Intensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, combined with glucuronide, only a small part of the ingested dose is excreted by the kidneys (less than 2%) and with feces (less than 7%). With the use of desloratadine in a dose of 5 mg to 20 mg once a day for 14 days, no signs of clinically significant cumulation were detected.

Indications

seasonal and year-round allergic rhinitis
chronic idiopathic urticaria.

Forms of release

The tablets covered with a cover of 5 mg.

There are no other dosage forms, be it syrup, drops or capsules.

Instructions for use and dosage

Adults and adolescents aged 12 years and older are prescribed inside, regardless of food intake, at a dose of 5 mg per day.

Children aged 1 to 5 years - 1.25 mg once a day, at the age of 6 to 11 years - 2.5 mg once a day.

Side effect

headache;
hallucinations;
psychomotor hyperreactivity;
convulsions;
dry mouth;
hepatitis;
photosensitization;
myalgia;
dyspnea;
feeling tired.

Contraindications

phenylketonuria;
pregnancy;
lactation;
children under 1 year;
hypersensitivity to desloratadine.

Application in pregnancy and lactation

Desloratadine is contraindicated in pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children under 1 year.

special instructions

With caution appoint desloratadine in severe renal failure.

Simultaneous food intake does not affect the distribution of desloratadine in the body.

Impact on the ability to drive vehicles and manage mechanisms

There was no adverse effect on driving or complicated technical devices.

Drug Interactions

In the study of drug interaction with multiple combined use with ketoconazole, erythromycin, azithromycin, Fluoxetine and cimetidine, no clinically significant changes in the concentration of desloratadine in plasma have been detected.

Desloratadine does not enhance the effect of alcohol on the central nervous system.

Analogues of the drug Desloratadine

Structural analogs for the active substance:

Alestamine;
Blogger 3;
Dezal;
Desloratadine Canon;
Desloratadine Teva;
Desloratadine Pharmaplant;
Desloratadine hemisulphate;
Lordestin;
Nalorius;
Ezlor;
Elisei;
Erius.

Analogues for the pharmacological group (H1 antihistamines):

Azelastine hydrochloride;
Allegra;
Allergodyl;
Allergoferon;
Allertec;
Astemizole;
Vibrocil;
Histaglobin;
Histalong;
Histafen;
Gifast;
Glencet;
Diazoline;
Diphenhydramine;
Dimenhydrinate;
Diphenhydramine hydrochloride;
Doxylamine succinate;
Dramina;
Zincet;
Zirtek;
Zodak;
Kestin;
Claritin;
Clarifer;
Clemastine;
Xizal;
Levocetirizine;
Lomilan;
Loratadine;
Lordestin;
Mebhydrogen;
Opatanol;
Parliamentary;
Pipolphen;
Rupafin;
Suprastinex;
Suprastin;
Tavegil;
Telfast;
Fexadine;
Fexofenadine;
Femizol;
Pheniramine maleate;
Fenistil;
Fenkarol;
Fenspiride;
Chloropyramine;
Chlorphenamine maleate;
Cetirizine;
Cetrin;
Eladon;
Erespal;
Erispirus;
Erolin.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: allergy, runny nose, rhinitis, hives, allergic rhinitis, chronic idiopathic urticaria