Omnadren 250 - instructions for use, analogs, testimonials and release forms (injections in ampoules for intramuscular injection), testosterone-based drugs for infertility, impotence, endometriosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Omnadren 250. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors specialists on the use of Omnadren in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Omnadrena in the presence of existing structural analogues.Use for the treatment of infertility, impotence, endometriosis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Omnadren 250 - an androgenic preparation containing a mixture of different testosterone esters. Testosterone is necessary for the formation of testicles, the prostate gland, seminal vesicles, and the development of secondary and tertiary sexual characteristics. Participates in the formation of the constitution of the body and sexual behavior, activates libido and potency, stimulates spermatogenesis, weakens the negative manifestations of men's menopause.

Testosterone is an antagonist of female sex hormones - estrogens. It causes inhibition of the gonadotropic function of the pituitary gland and suppresses the function of mammary glands in women. During the treatment, there may be phenomena of masculinization.

Testosterone has an anabolic effect: it stimulates protein synthesis, increases calcium fixation in bones, increases muscle mass, stimulates the formation of Erythropoietin in the kidneys, raises hemoglobin levels in the blood. In connection with this, it is used in sports medicine to improve the strength and endurance of athletes in power sports and marathon distances.Refers to prohibited drugs (dope).

In healthy men, the administration of exogenous testosterone inhibits the release of one's own (endogenous) hormone by inhibiting the secretion of LH. In high doses, the drug suppresses spermatogenesis, influencing the reverse inhibition of FSH secretion.

In men with functional pituitary insufficiency, testosterone removes the symptoms of hypogonadism. If impotence is not caused by hypogonadism, then the drug does not work.

Ester testosterone esters have different rates of absorption and elimination, which provides rapid development of the effect and a prolonged effect (up to 4 weeks) after a single injection: testosterone propionate is active during the first 24 hours, the action of testosterone phenylpropionate and isocaproate begins 24 hours after injection and lasts up to 2 weeks. Testosterone capronate begins its action at a time when the effect of testosterone isocapro- nate and phenylpropionate is discontinued.

Composition

Testosterone propionate + Testosterone phenylpropionate + Testosterone isocaproton + Testosterone decanoate + excipients.

Pharmacokinetics

The binding to plasma proteins (with a specific fraction of globulins) is about 98%. Metabolised in the liver with the formation of various 17-ketosteroids, which after the connection with glucuronic or sulfuric acid are excreted in the urine. Derived about 90% of the kidneys in the form of metabolites, 6% - through the intestines in an unrelated form.

Indications

In men:

• post-stroke syndrome;
• oligospermia;
• eunuchoidism;
• hypopituitarism;
• impotence;
• male menopause;
• Androgen deficiency (including Addison's disease, pituitary tuberculosis, adiposogenital syndrome);
• infertility (impaired spermatogenesis).

Among women:

• osteoporosis (against a background of androgen deficiency);
• mammary cancer;
• ovarian cancer;
• dysfunctional uterine bleeding with hyperestrogenism;
• uterine myoma;
• endometriosis;
• premenstrual tension syndrome;
• states associated with menopause (in combination with estrogens);
• for the virilization of the external genitalia with various forms of hermaphroditism.

Forms of release

Solution for intramuscular injection (injections in ampoules for injection).

Other dosage forms, be it tablets or capsules, do not exist.

Instructions for use and how to use them

The drug is injected intramuscularly deep into the gluteus muscle.

Doses are set individually, depending on the indications and the patient's response to treatment.

Usually prescribe 1 ml 1 time in 28 days.

In primary male hypogonadism, depending on the degree of insufficiency of the gonads (according to the clinical evaluation and the results of laboratory tests) Omnadren 250 is administered v / m 1 time every 7-14-21 days.

At the beginning of treatment, the drug is administered every 7-14 days, and after reaching the therapeutic effect 1 time in 21 days.

In men's climax, Omnadren 250 is administered once every 14 days, after the development of the therapeutic effect - once every 21 days.

Infertility in men (azoospermia, oligospermia) Omnadren 250 is prescribed 2 ml once every 14 days.

In the case of a painful erection of the penis should stop treatment with the drug.

Women with menopausal syndrome appoint 1 ml 1 time every 14-21 days.

In breast and ovarian cancers - 1-2 ml each 7-14 days for a long time.

Side effect

• in women - dysmenorrhea, inhibition of gonadotropin secretion, masculinization, hirsutism;
• in men - gynecomastia, priapism, oligospermia, impaired spermatogenesis;
• in boys - premature puberty, premature closure of the epiphyses of bones;
• violation of libido;
• acne;
• male pattern baldness;
• nausea;
• abnormal liver function;
• hepatic purpura;
• tumor liver disease;
• cholestatic jaundice;
• increased activity of hepatic transaminases;
• inhibition of plasma clotting factors 2, 5, 7 and 10;
• bleeding in patients taking anticoagulant drugs inside;
• polycythemia;
• headache;
• fear;
• paresthesia;
• increase in cholesterol in the blood plasma;
• inflammation and pain at the injection site.

Contraindications

• established or suspected carcinoma of the prostate;
• gynecomastia;
• hypercalcemia;
• hypercalciuria;
• heart failure;
• kidney failure;
• liver failure;
• asthenia;
• use in boys in the prepubescent period;
• use in men of advanced age;
• pregnancy;
• breast-feeding;
• hypersensitivity to the drug.

Application in pregnancy and lactation

The drug Omnadren 250 is contraindicated for use in pregnancy.

If you need to use the drug during lactation, breastfeeding should be discontinued.

Use in children

It is acceptable to use Omnadren 250 in boys since puberty (puberty).

special instructions

The drug can not be administered intravenously.

Androgen therapy in breast cancer may be the cause of hypercalcemia associated with the stimulation of osteolysis. This process can increase metastasis in the bone system. When treating women Omnadren 250 should monitor the concentration of calcium in the blood serum.

When assigning androgenic drugs in high doses, it is necessary to monitor the level of hemoglobin and hematocrit.

If there are symptoms of hepatitis, jaundice, or changes in liver function indicators, Omnadren 250 should be revoked and the etiology of these changes should be determined. It is necessary to monitor the state of liver function.

In elderly men, the risk of developing hypertrophy or prostate cancer increases. Before and after treatment, it is necessary to examine the condition of the prostate and monitor the level of PSA.

In patients with diseases of the cardiovascular system, liver or kidney in the development of peripheral edema, the drug should be discarded.

With care, prescribe androgen therapy to patients with delayed puberty. In this category of patients should monitor the condition of the osseous system every 6 months.

The use of Omnadren 250 as a dope can cause serious side effects.

The drug is released by prescription.

Impact on the ability to drive vehicles and manage mechanisms

There was no direct influence of Omnadren 250 on the ability to drive vehicles and work with mechanisms. Deterioration of concentration and decrease in the speed of psychomotor reactions is possible with the development of heart failure.

Drug Interactions

In patients receiving anticoagulants inside, with the simultaneous use of Omnadren 250, especially at the beginning and with the withdrawal of therapy, constant monitoring of blood coagulation is required.

In patients with diabetes, androgenic drugs can reduce blood glucose levels and the need for insulin.

When Omnadren 250 is used with ACTH or glucocorticosteroids (GCS), the risk of peripheral edema is increased, especially in patients with liver or cardiovascular disease.

Drugs that cause the induction of microsomal liver enzymes (including rifampicin, barbiturates, carbamazepine, salicylates, phenylbutazone, phenytoin, primidone), can reduce the effects of testosterone.

Analogues of the drug Omnadren 250

Structural analogs for the active substance:

• Andriol;
• Androgel;
• Nebido;
• Sustanon 250;
• Testosterone propionate;
• Test for injection 10%.

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