Gistan - instructions for use, reviews, analogs and forms of release (Cream 0.1% H, ointment or gel, capsules or tablets 200 mg and 300 mg) of a hormonal drug for the treatment of dermatitis, allergies in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Gystan. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Gistan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Gistan in the presence of existing structural analogues.Use for the treatment of dermatitis, psoriasis, skin itching and skin manifestations of allergy in adults, children, as well as during pregnancy and lactation. Composition of the hormonal drug.

Gystan - synthetic glucocorticosteroid (GCS). Has anti-inflammatory, antipruritic and antiexudative action. SCS induces the release of proteins that inhibit phospholipase A2 and are known collectively as lipocortins that control the biosynthesis of inflammatory mediators such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.

It prevents the accumulation of neutrophils, which reduces inflammatory exudate and production of cytokines, inhibits the migration of macrophages, leads to a decrease in the processes of infiltration and granulation. Reduces inflammation by reducing the formation of the chemotaxis substance (influence on late allergy reactions), inhibits the development of an immediate allergic reaction (due to inhibition of the production of arachidonic acid metabolites and a decrease in the release of inflammatory mediators from mast cells).

With daily application of the cream to children over 2 years old with allergic dermatitis, the therapeutic effect is manifested in 3 weeks.

Composition

Mometasone furoate + excipients.

Pharmacokinetics

Absorption of Gistant H cream is low. 8 hours after application on intact skin (without occlusive dressing), about 0.4% of the dose is found in the systemic blood stream. With inflammation and damage to the skin, absorption increases.

Indications

• inflammation and itching of the skin with dermatoses (including psoriasis, eczema, atopic dermatitis, seborrheic dermatitis), in which therapy with glucocorticosteroids is indicated.

Forms of release

Cream for external use 0,1% (Gistan H) (sometimes mistakenly called ointment or gel).

Capsules 200 mg and 300 mg (sometimes mistakenly called pills).

Instructions for use and how to use them

Cream

Outwardly.

A thin layer of the drug is applied to the affected areas of the skin once a day.

Duration of treatment: 7-28 days, determined by the effectiveness of therapy, as well as patient tolerability, the presence and severity of side effects.

Side effect

• burning;
• itching;
• paresthesia;
• folliculitis;
• acne;
• skin atrophy;
• hypertrichosis;
• hypopigmentation;
• perioral dermatitis;
• allergic contact dermatitis;
• maceration of the skin;
• secondary infection;
• stria;
• prickly heat;
• adrenal insufficiency;
• syndrome Itenko-Cushing.

Contraindications

• pink acne, perioral dermatitis;
• bacterial, viral (Herpes simplex, chicken pox, Herpes zoster) or fungal skin infection;
• tuberculosis, syphilis;
• postvaccinal reactions;
• pregnancy (treatment of extensive skin areas, long-term treatment);
• lactation period (use in large doses and / and for a long time);
• children's age up to 2 years;
• hypersensitivity to any component of the drug or to other GCS.

Application in pregnancy and lactation

The safety of Gistan during pregnancy and lactation has not been studied.

GCS penetrates the placental barrier. Long-term treatment and use of large doses during pregnancy should be avoided due to the threat of adverse effects on fetal development.

GCS is excreted in breast milk. In the event that the use of GCS is expected in large doses and / or for a long time, breastfeeding should be discontinued.

Use in children

Gystan is contraindicated in children under 2 years of age (including infants and newborns).

Due to the fact that the ratio of surface area and body weight is greater in children than in adults, children are at greater risk of suppressing the function of the hypothalamic-pituitary-adrenal system and the development of the Itenko-Cushing syndrome with any local GCS. Long-term treatment of children with SCS can lead to disruption of their growth and development. The use of the drug in children for more than 3 weeks has not been studied.

Children should receive a minimum dose of the drug sufficient to achieve the effect.

special instructions

If there is no effect within 2 weeks of therapy with Gistan, the diagnosis should be clarified.

When applied to large areas of the skin for a long time, especially with the application of occlusive dressings, it is possible to develop a systemic action of GCS. Given this, it is necessary to monitor the function of the hypothalamic-pituitary-adrenal system.

Avoid contact with the eyes. Not intended for use in ophthalmology.

Newborns, whose mothers during pregnancy used SCS,should be carefully examined to identify possible hypofunction of the adrenal glands.

Propylene glycol included in the formulation may cause irritation at the site of application. In such cases, discontinue use of the drug and prescribe appropriate treatment.

It should be borne in mind that SCS is able to change the manifestation of certain skin diseases, which can complicate the diagnosis. In addition, the use of GCS may be the cause of delayed wound healing.

With prolonged therapy with SCS, sudden discontinuation of therapy can lead to the development of a rebound syndrome, manifested in the form of dermatitis with intense reddening of the skin and a burning sensation. Therefore, after a long treatment course, the drug should be abolished gradually, for example, by switching to an intermittent treatment regimen before it is completely discontinued.

Drug Interactions

Not found.

Analogues of the drug Gystan

Structural analogs for the active substance:

• Avecourt;
• Asmaneks Twistheiler;
• Gistan H;
• Desrinitis;
• Momat;
• Momederm;
• Mometasone furoate;
• Monovo;
• Nazonex;
• Silkarene;
• Uniderm;
• Elokom;
• Elok Lotion.

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