Serrata - instructions for use, reviews, analogs and formulations (tablets) of a medicinal product for the treatment of dislocations, sprains, edema and improvement of blood microcirculation in adults, children and during pregnancy. Composition

In this article, you can read the instructions for using the drug Serrata. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Serrata in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Serrata in the presence of existing structural analogues. Use to treat dislocations, sprains, edema and improve blood microcirculation in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Serrata - contains the active component of serratiopeptidase. Serratiopeptidase enzyme, which has proteolytic activity, which is released from the bacterium Serratia E15, which is part of the non-pathogenic intestinal microflora. The drug has fibrinolytic and anti-inflammatory activity. When the drug is used, there is also a marked anti-edematous effect. The pharmacological effects of serratiopeptidase are realized by reducing the concentrations of bradykinin, histamine and serotonin in the inflammatory focus. Reduction of mediator concentrations in synaptic clefts occurs due to their hydrolysis under the action of serratiopeptidase, while the intensity of release and re-uptake of mediators does not change. The drug reduces the dilatation of blood vessels and reduces their permeability. The analgesic effect of the drug is achieved by reducing the release of amines from inflamed tissues.

The body binds serratiopeptidase and a2-macroglobulin blood, which leads to a decrease in the antigenicity of serratiopeptidase, but does not reduce its proteolytic activity. The drug reduces the activity of plasmin inhibitors, thus increasing the fibrinolytic activity of plasmin.

The drug also contributes to the improvement of sputum discharge, since serratiopeptidase is able to reduce edema and improve blood microcirculation.

Composition

Serratiopeptidase + auxiliary substances.

Pharmacokinetics

The drug after oral administration is well absorbed in the intestinal tract, while not changing under the influence of gastric juice. After some time after application of the concentration in the site of inflammation significantly exceed the concentration of serratiopeptidase in the blood. It is excreted from the body with urine.

Indications

Surgery:

• fractures;
• dislocations;
• sprains;
• edema of various nature, including postoperative edema;
• prevention of graft rejection.

Application in plastic surgery:

• improvement of microcirculation to prevent graft rejection;
• reduction of swelling after surgery.

Application in ENT-practice:

• otitis;
• sinusitis and other inflammatory diseases of the ENT organs, which are accompanied by increased secretion and difficulty in sputum discharge.

Application in dermatology:

• acute dermatoses.

Application in obstetrics and gynecology:

• elimination of edema of mammary glands of various nature.

The drug is also used to accelerate the resorption of hematomas.

Serrat is also used to reduce the viscosity of sputum and improve the penetration of antibiotics in various diseases of the upper respiratory tract.

Forms of release

Tablets, covered with enteric coating.

Instructions for use and dosing regimen

The drug is taken orally, regardless of food intake. The tablet is swallowed whole, without chewing, squeezed with enough liquid. The duration of the course of treatment and the dose of the drug depends on the nature and dynamics of the disease, as well as the individual characteristics of the patient. Usually prescribe the drug 1 tablet 3 times a day, however, if necessary, the dose of the drug can be changed by the doctor in charge.

Side effect

The drug is usually well tolerated by patients, however, in some cases, side effects such as stool, nausea, vomiting, and stomach pain were observed. Some patients showed loss of appetite. Also, in patients prone to bleeding, there may be an increase in nosebleeds or a sputum discharge with blood. Hypersensitivity reactions in the form of hives, skin rashes and itching.

Contraindications

• hypersensitivity to serratiopeptidase or other components of the drug;
• bleeding disorders and / or a tendency to bleeding.

Application in pregnancy and lactation

The drug does not have teratogenic, mutagenic and embryotoxic effects on the fetus, however, the experience of using Serrath during pregnancy is limited. The drug can be prescribed during pregnancy only for life indications and under the strict supervision of the attending physician.

There is no experience of using the drug during lactation.

Use in children

In view of the lack of experience in the use of the drug in children, its appointment is possible only according to vital indications and under the strict control of the attending physician.

special instructions

Since the drug affects the blood coagulation system, it should be used with caution in the following conditions:

• threat of bleeding;
• violation of clotting time;
• taking anticoagulants;
• severe liver disease;
• severe kidney disease.

The drug contains lactose, so it should not be used in patients with rare hereditary diseases, such as galactose intolerance, lactase deficiency or malabsorption of glucose-galactose.

Influence on ability to drive vehicles, mechanisms

There is no data on the negative effect of serratio-peptidase on reaction rate when driving vehicles or other mechanisms.

Drug Interactions

The drug with simultaneous application increases the action of anticoagulants direct and indirect action. If necessary, combinations of these drugs are used under strict medical supervision and, if necessary, correct the dose of anticoagulants.

Analogs of Serrat medicinal product

Structural analogs for the active substance:

• Serate;
• Serox;
• Serta.

Analogues on the curative effect (remedies for hematoma):

• Amben;
• Aminocaproic acid;
• Gumbix;
• Contrikal;
• Polycapra;
• Protamine sulfate;
• Remestip;
• Hemostatic napkins;
• Simesan;
• Stabisol HES 6%;
• Stylamine;
• Thysukol Kit;
• Tranexam;
• Transacha;
• Trasilol 500,000;
• Exacil;
• Etamsylate.

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