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Sofosbuvir - instructions for use, reviews, analogs and dosage forms (tablets 400 mg Sovaldi) drugs for the treatment of hepatitis C genotype 1, 2, 3 and 4 in adults, children and pregnancy. Composition, price and prospects of entering the Russian market

Sofosbuvir - instructions for use, reviews, analogs and dosage forms (tablets 400 mg Sovaldi) drugs for the treatment of hepatitis C genotype 1, 2, 3 and 4 in adults, children and pregnancy. Composition, price and prospects of entering the Russian market

In this article, you can read the instructions for using the drug Sofosbuvir. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Sofosbuvira (Sovvaldi) in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Sofosbuvir in the presence of existing structural analogues.Use for the treatment of hepatitis C genotype 1, 2, 3 and 4 in adults, children, as well as during pregnancy and lactation. Composition, cost and prospects of the drug on the Russian market.

 

Sofosbuvir - the nucleotide analogue is used in combination with other drugs for the treatment of hepatitis C. On the world market from 2013. Compared with other medicines, sophosbuvir showed higher efficacy, fewer side effects and a 2-4 times shorter duration of therapy. Sofosbuvir allows you to stop using Interferon alfa-antiviral drug with a series of side effects, the main element in the treatment of hepatitis C in many countries, including Russia.

 

Sofosbuvir inhibits RNA polymerases used by the hepatitis C virus to copy its own RNA. Sofosbuvir is produced by the company Gilead.

 

>> How to buy Sofosbuvir in Russia <<

 

In 2013, the Food and Drug Administration in the United States approved the use of somosbuvira in combination with Ribavirin as non-injectable hepatitis C therapy for the 2nd and 3rd genotype, and for combined triple therapy (cofosbuvir + ribavirin (oral) ) + interferon alfa (injections)) for the treatment of hepatitis C of the 1st and 4th genotypes.In 2014, a successful combination of sophosbuvira with lepidavir opened the possibility of treating hepatitis C of the first genotype without the use of interferon alfa. Clinical data on the use of sophosbuvira in patients with genotype 5 or 6 are limited.

 

Composition

 

Sofosbuvir + auxiliary substances.

 

Indications

  • chronic hepatitis C of genotype 1, 2, 3 and 4 (in combination therapy).

 

Forms of release

 

Tablets 400 mg (under the trademark Sovaldi (Sovaldi)).

 

Instructions for use and treatment regimen

 

Therapy should be conducted only by physicians with experience in the management of chronic hepatitis C. It is recommended that the drug be used in combination with other medicines. Софосбувими monotherapy is not recommended.

 

The recommended dose for adult patients is one 400 mg tablet per day during one meal.

 

Combination Therapy

  • With hepatitis C of genotype 4, 5 or 6, a combination of Sovaldi (somosbuvir) + ribavirin + Interferon alfa is used for more than 12 weeks.
  • In hepatitis C genotype 1, 4, 5 or 6 - with ribavirin (only in patients with contraindications to the use of interferon alfa or having intolerance to interferon) for more than 24 weeks.
  • With hepatitis C of genotype 2 - with ribavirin for more than 12 weeks.
  • With hepatitis C of genotype 3 - with ribavirin and interferon alpha more than 12 weeks.
  • Patients with hepatitis C who are waiting for a liver transplant receive a combination of cofosbuvir + ribavirin before transplantation. The scheme is valid for patients with co-infection with hepatitis and HIV.

 

The duration of therapy can be increased to 24 weeks, especially in patients with one or more negative factors, such as progressive fibrosis / cirrhosis, high initial viral load, black skin, previously no response to ribavirin and interferon alfa.

 

The dose of ribavirin for combination therapy depends on the weight of the patient (75 kg = 1,200 mg), divided into two parts and is also taken with meals.

 

It is not recommended to reduce the dose of sophosbuvira.

 

If the combined use of cofosbuvira with interferon alpha, serious side effects associated with this drug occur, you should reduce the dose of interferon or completely cancel the drug. The rules for reducing the dose or stopping the use of interferon are prescribed in special instructions.

 

If serious side effects associated with ribavirin occur, the dose of ribavirin should be reduced accordingly or the drug should be completely withdrawn.The rules for reducing the dose or stopping ribavirin intake are prescribed in special instructions.

 

After abolishing ribavirin based on improved blood tests and clinical symptoms, you can try to resume taking the drug at a dosage of 600 mg daily, increasing it to 800 mg. However, further administration of the drug at the initial dose (1,000 mg and 1,200 mg daily) is not recommended.

 

Method and duration of admission

  • Because of the bitter taste, the tablet should be swallowed without chewing or dividing into parts. Take with food.
  • If there is vomiting within 2 hours after taking the medication, you should take an extra pill. In the case of vomiting after 2 hours, no additional pill is needed.
  • If the medication is missed, if you are less than 18 hours late, you must take the missed pill. The next tablet is taken at the usual time. At a delay of more than 18 hours, take the next tablet at the usual time.

 

Discontinuation of treatment

 

With the complete cancellation of one of the drugs with a combined admission, you should cancel and receive sophosbuvira.

 

EASL 2017 Guidelines for HCV Therapy

Sofosbuvir - instructions for use, reviews, analogs and dosage forms (tablets 400 mg Sovaldi) drugs for the treatment of hepatitis C genotype 1, 2, 3 and 4 in adults, children and pregnancy. Composition, price and prospects of entering the Russian market

picture clickable

 

Side effect

  • insomnia;
  • headache;
  • migraine;
  • decreased appetite;
  • convulsions;
  • dizziness;
  • nausea, vomiting;
  • diarrhea, constipation;
  • dry mouth;
  • fatigue;
  • depression;
  • irritability;
  • anemia, neutropenia, a decrease in the number of lymphocytes and platelets;
  • skin rashes;
  • itching;
  • rash;
  • pain in the joints;
  • myalgia;
  • chills;
  • fever;
  • cough;
  • rhinopharyngitis;
  • impaired vision;
  • hair loss;
  • dry skin;
  • chest pain;
  • asthenia.

 

Contraindications

  • hypersensitivity to the drug and its components.

 

Caution should be used in women of reproductive age.

 

Application in pregnancy and lactation

 

Caution should be used in women of reproductive age. When applying Sovaldi (Sofosbuvira) in combination with ribavirin and interferon alpha, the onset of pregnancy is undesirable. Avoid the use of medication during pregnancy and lactation. There are no data on the effect of the drug on reproductive performance.

 

Use in children

 

Data on the safety and efficacy of taking Sofosbuvira in children and adolescents under the age of 18 are not available.

 

special instructions

 

The price of Sofosbuvir in the United States varies from $ 84,000 to $ 168,000 per course for different rates, in the UK, 35,000 pounds for a 12-week course.In September 2014, Gilead announced that it will issue production licenses for 91 developing countries. The estimated cost of sophosbuvira in India or China is estimated at $ 300 per course.

 

At the end of 2015, Sofosbuvir is in the process of preparing for registration in Russia. It is worth to expect the appearance of this drug in our market in the foreseeable future. Perhaps (due to the spread of generics), at that time the medicine will have an adequate cost of treatment available to our patients, including free-of-charge programs.

 

The drug is included by WHO in the list of essential medicines.

 

Drug Interactions

 

The use with other antiviral drugs can be allowed only if, according to available data, the benefit exceeds possible risks. It is not recommended to take cofosbuvira and telaprevir or boceprevir together. It is not recommended to take together with drugs that are strong inducers of glycoproteins in the intestine (rifamycin, zveroboi, carbamacepin and phenytoin).

 

Analogues of the drug Sofosbuvir

 

Structural analogs for the active substance:

  • Viropak (MPI Viropack) (Egypt);
  • Grateziano (Egypt);
  • Hepcinat (India);
  • Hopetavir (Bangladesh).

 

Analogues on the curative effect (drugs for the treatment of chronic hepatitis C):

  • Algeron;
  • Altevir;
  • Alfaron;
  • Asunaprevir;
  • Daklataswir;
  • Ingaron;
  • Intron A;
  • Layfferon;
  • Ladipasvir;
  • Moliksan;
  • Neovir;
  • Pegasys;
  • Peginterferon;
  • PegIntron;
  • Realdiron;
  • EU Reaferon;
  • Rebetol;
  • Ribavirin Meduna;
  • Ribamidyl;
  • Roferon A;
  • Sovriad;
  • Ferrovir;
  • Cycloferon.

Similar medicines:

Other medicines:
Reviews (124):
Guests
zhigatova asiyat karalbievna
With hepatitis C genotype 1, how much should you take safosbuvir and ribavirin to be cured completely?
Administrators
admin
zhigatova asiyat karalbievna, The instructions say that the course of joint treatment with Sofosbuvir and Ribavirin for hepatitis C genotype 1 should be at least 24 weeks. Specific terms are decided by the attending physician, it is better if it is an infectious disease specialist familiar with such treatment regimens.
Guests
Eugene.
For the first genotype, the schemes of cofosbuvir + daklatasvir or harvoney for 12 weeks are effective. We know not by hearsay.
Guests
Arkady
And when this medicine will be released specifically to the Russian market? 2016 in the yard ...
Administrators
admin
ArkadyWhen our bureaucrats make all reconciliations and duplicate the research, which the creators of Sofosbuer have already carried out for them. And the people will be poisoned by contraband supplies from crooks and that kind of therapy. Do not ask me questions that I do not have an answer for :(
Guests
Elvira Serazetdinova
Where can I buy this drug?
Administrators
admin
Elvira Serazetdinova, Currently Sofosbuvir can be purchased only abroad. Why? This question I answered already above - all because of our bureaucracy and reinsurers-officials.
Guests
Alexey8080
I had such a therapy: Sof + Rib + Duck, after the first canned bottle Rib. as acne on the forehead began to get out (pobochka) and the second bank drank one Sof.
Treated the genotype 3a, F-0. Ordered directly from India sophosbuvir MyHep 28 tab. (6 cans). In the end, the minus showed after the second bank (maybe it was before, I once took the analysis).
Guests
Surgey
For such babki and so many side effects!
Guests
Tanya
How to buy, so as not to be deceived? Tell me please. Why beware?
Administrators
admin
Tanya, I will not tell you in any way, I have never worked with the shadow market. You can rely on such a case only for the responses of people you know who received from someone Sofosbuvir and have a positive result. Otherwise, all are lying and the opinions of Internet sellers are skeptical. In this situation, I think the state and the controlling medical structures are more guilty, which delay the registration and necessary research, when the whole world enjoys a valuable progress in progress.
Guests
Arthur
Only buy the country of India, the firm nakto, it helps well.
Guests
Dimas
Sophosbuvir is now sold with a ladybessvir and is called Hepcinat-Lp. It costs about $ 450 per package. We need a maximum of 3 per course for 3 months. Of the side effects - easy fatigue. To solve to you than it is treated. Effective in genotype 1, 3, 4.
Guests
ALEXEY MAGNITOGORSK
Sellers on the site (the network of suppliers) are offered for a price lower than in India itself. A friend of mine sent me a Hindu. A palenku somewhere in the villages spank.
Visitors
shahlo
I use sophosbuvir plus ribavirin for 2 weeks already. I was assigned for 12 weeks. A few days there was a slight pain in the right side. This is normal? I have Hepotitis C genotype 1c low activity. Thank you.
Administrators
admin
shahlo, The drug is new, so no one knows the consequences of its administration until the end, even the manufacturer of the original Sofosbuvira. From what is at the moment, patients with pain in the liver region are noted. I do not know your medical history to the end, so I advise you to consult your doctor for differential diagnosis of the pain.

And more it is necessary to be sure of the purchased product, so that it is not some kind of poison under the guise of a medicine that destroys the sick liver even more.
Visitors
ARSLAN
A good drug, I recommend. A couple of friends were cured due to the course of duck and soph (sophosbuvir and daklatasvir), Egyptian, where $ 800 for a 12-week course was a couple of months ago, I do not know now. In Egypt, the laws are strict and the tablets are not decided to forge. Earlier they say the death penalty for it was, I do not know the truth or not ...
Guests
Vitalina
Good afternoon, at the husband a hepatitis 3 type, an active virus, a fibrosis F3. Plus hepatic tests go off scale (683d). We were given a 12-week dac-sofa. And I heard that under this scheme, he only leaves for a while. And it is better to drink 24 weeks. Then there will be a net result. Who has heard about this?
Administrators
admin
Vitalina, Type 3 genotype, plus fibrosis - I think 12 weeks your husband may not be enough. The proposed scheme (usually here add Ribavirin) is really better to take 24 weeks.
Guests
Matchanov Ruslan Rustambaevich
Efficiency how many percent?
Administrators
admin
Matchanov Ruslan RustambaevichBased on the question - 50 to 50. Either help, or not. And so Sofosbuvir is a good drug and in the majority of patients against the background of therapy this drug has a stable remission.
Guests
Marat
Guys, who has overtaken this muck drink sophosbuvir + daklatasvir!
Visitors
shahlo
Hello. I'm Shahlo from Tajikistan. May 14, 2016 began treatment of hepatitis C, genotype 1b cofosbuvir plus ribavirin.

July 04, 2016 passed the analysis. There is no virus activity. But the virus analysis is still positive for hepatitis C. Why?

With the rules of the doctor who oversees me. He says that the virus is in the blood and can not be removed from the blood. In India, physicians have guaranteed complete cure for hepatitis C with sophosbuvir.

What should I do?
Administrators
admin
shahlo, Sofosbuvir suppresses the hepatitis virus, and it does it more than all known drugs at the moment, because it is innovative and gives good results.A completely free of the virus can only the human body, its immune system. This is extremely rare, isolated cases, but I have observed this a couple of times and described in the literature. So your doctor is right, and Hindus need to sell medicine. For your money, they will give any guarantees, and can also offer a second course of treatment to pass. For such money is quite ...
Administrators
admin
I do not have any ads and I will not. Unknown Indian suppliers Sofosbuvira to Russia and their local representatives do not have any legal channels of supply, so buying through them is a lottery. Someone will help, but most will face deception and fraud. Understand who has a quality product, and who does not have the opportunity I do not. I'm not a controlling authority, so this kind of advertising is banned. Do not try to bypass filters and moderation.
Guests
Dima
Healed from hepatitis C for 12 weeks with drugs sophosbuvir + daklatasvir (production of Egypt). Now I distribute ...
And advertising on the site is prohibited, especially by the sale of drugs through unofficial channels. Responsibility, however, you will not carry anything, if that suddenly ...
admin
Guests
IRINA
Hello everyone. Has passed or has taken place a course svaldi, ribavirin and daklenza for 24 weeks. I passed the course successfully and without side effects. Despite the menopause, everything is all right.
Guests
Lyudmila
Hello. Ordered drug sophosbuvir with daklatasvir course 12 weeks, with India the lowest price. They were afraid that they were suddenly deceiving, but they drank a month and the analysis was good right away. At me the hepatitis With 2 genotype it was possible to tell or say with confidence. Having received negative analyzes I in the car so shouted with pleasure that people sitting in cars, turned around. I wish everyone good health! I'm a disabled person of the 2nd group, but I cut through without any side effects.
Visitors
asw
Hello!
I here found Sofosbuvir on the site of the state (reference book of medical medicines). On the site there is Sofosbuvir (Sowaldi) Irish. It costs 69,000 rubles. Here is the link *** deleted for doubt *** I ask the Administrator to admit the link, as this site is recommended by many doctors for the search for drugs.This is not advertising, but my desire to help people! And I have a question: my wife will be treated in the second infectious hospital where she has a "Center for the treatment of chronic viral hepatitis" for a free program, what can you expect from such treatment, what drugs are used and is it effective? She has a genotype 3a with a low activity of ALT 39.5. Whether it is necessary to be treated there generally or better on a paid basis, but only here at whom? Now we are seeing a hepatologist at the "Institute of Gastroenterology" in Moscow, but doctors there for 20-25 years, this is confusing because they do not have enough experience and their vast base of patients (statistics). What is the best way to proceed?
Sincerely.
Administrators
admin
asw, One pharmacy selling a drug that is not registered in the Russian Federation? It is more similar to advertising of this drugstore. Also at a price somehow cheap it goes. In general, it is doubtful, but at least in the pharmacy, and not on the left and absolutely obscure sites, where the purchase turns into a lottery, so you can call and find out.

Therefore, the recommendations in the Directory of sites that sell Indian, Egyptian and other generics Sofosbuvira there,because I can not guarantee the quality of the drugs I buy, and if I can not, I better keep silent, it's more honest. Although many look established a good business for deliveries, including useless dummies, under the guise of analogues Sofosbuvira and actually rob the sick people and their relatives. This is immoral and an occasion for law enforcement to deal with such businessmen. It is better to register all possible original drugs and their analogues and sell legally, but this is a policy mixed with corruption, so I'll leave this point indiscriminately.

According to the free program, your wife will probably be offered treatment with interferons, although it is possible that local doctors can offer proven supplies of Sofosbuvira or its analogues cheaper (they have more experience in treating specifically hepatitis), so it's worth to be treated anyway. I will not say about the quality of the medical institution itself, it depends more on the specific doctor who treats the patient. And paid-free also weakly correlates with the result. It is necessary to look for your doctor who will treat and will be interested in the final result of the treatment and no matter how interested you are. Free medicine in its pure form is a myth.
Visitors
asw
admin, Hello! Excuse for troubling. No, I did not advertise the pharmacy in my question, it's just that this drugstore has been working for a long time and on television it was once untwisted, and it's kind of known enough. Is it possible to sell counterfeit there? About the drug in this drugstore: I just figured out that the price is kind of reasonable 69000 - it's a little over $ 1000, the course of 3 cans is = $ 3000. In the beginning I decided that I could buy it, but after your comment that it is not registered in Russia, I now do not know what to think about it. After all, this site is obtained only by them they trade for the whole of Moscow. But to be honest, I was also embarrassed that the Irish drug is not much more expensive than the Indian one. And the certificate for the drug can be fake or bought from those who issue them. After all, all these drugs are very expensive and you can make good money on them, it's not a cheap penny. Maybe in this "Center" I will be prompted, where to find it and how?
P.S. Can then remove the link? Suddenly, people will buy, no matter what, and harm themselves, even if a harmless dummy turns out to be good, although money is also not for someone to experiment with.
Thank you for attention.
Sincerely.
Administrators
admin
aswI'll try to remove the link, but otherwise I share your doubts. For myself, I derived a formula for the means by which a person is willing to take risks. It is clear that new drugs from hepatitis now well entered the market and there is an effect. On the other hand, original preparations based on Sofosbuvir Sowaldi are available to a few, and among the analogs there are many charlatans. Therefore, the recommendations are as follows: to look for infectious disease specialists who work with proven suppliers of analogues, read forums and not risk the last money.
Administrators
admin
Site visitor question Alex Blinoff moved to the required section:
Hello! You wrote in one of your comments the following:
A completely free of the virus can only the human body, its immune system. This is extremely rare, isolated cases, but I have observed this a couple of times and described in the literature.

Is my wife not cured to the end. She and will be ill with a hepatitis?
You just killed it! Of course, I will not tell her anything about this and will create a positive and emotional mood for her. But still?

Alex Blinoff, While all this is so. All that manufacturers so loudly declare, including effective Sofosbuvira and its derivatives, is the reduction of the viral activity of the pathogen to almost zero. It is possible that your wife will continue to exist for many years with this zero activity, after the treatment with innovative drugs, or maybe not. Long-term experiments have not been conducted on a scale of decades, so everyone will find out about the fact, including new side effects and contra-indications of Sofosbuvira and its qualitative counterparts.
Guests
Irina
Hello, but I took a chance and bought an Egyptian sofa from the overhaul. and Duck. Now I have been drinking for two weeks, the analysis has not yet passed, I will report the results later. 550 dollars the course cost for 12 weeks.
Guests
Sofia Grachev
Hello. Saw these pills in the treatment of hepatitis C, after the first month of taking hepatitis is not found. These pills are just a miracle, giving hope to people to live a full life.Prompt, please, through what time after the termination of reception of tablets it is possible to become pregnant?
Administrators
admin
Sofia GrachevMore than what is in the instructions at the moment I do not. There are also no data on the effects on reproductive function in women and men of the drug Sofosbuvir. Everything will be learned in the process of using. The half-life of the drug is 27 hours, so hypothetically it is possible to become pregnant 2 days after the end of treatment. But it seems better to wait a month or two, wait for stabilization of the main indications of health and then with a doctor to make a decision about a possible pregnancy. Plus, increased control during gestation with control over the indications of one's own health and fetus.
Guests
Victoria
Kind time of the day! At the husband a hepatitis C and B. With B all is clear. Hepatitis C was treated with pegintron + ribavirin. After a month of treatment there was an answer. Hepatitis ceased to be determined. But a few months later there was a relapse. Repeat treatment with Pegasus we did not recommend; can be worse.Now we have learned about the miracle of treatment, now we do not know what to do. Read the reviews, not one bad did not see. Is it really helping everyone 100%?
Administrators
admin
Victoria, Treatment with Sofosbuvir at the moment helps many patients and with good stable remission results. Whether it suited your husband, find out from the doctor who watches him, since there are restrictions on the hepatitis C genotype, there may be other moments not indicated by you in the question.
Guests
Maria27
Hello! We with the husband were on consultation at infektsionista in the Stavropol regional speed center (under a registration of the husband). The doctor talked a lot about sophosbuvir and its high efficiency, as in her observations of patients all are very favorably treated. On the question of where to buy drugs, nothing concrete said and looked down, on the sheet wrote the name of some program with a hint that the house will understand. And for me it means nothing and at home I did not understand anything! Now she went on leave until September 28.My husband and I did not waste time, returned to my homeland, but here about Sofosbuvir, even private clinics did not hear anything.
Guests
olga
I take the drug Sofosbuvir + daklatasvir 5 weeks. I was diagnosed with hepatitis C 1c, Today I received the results of PCR "qualitative" negatively. I'm happy madly. The course of treatment is 3 months. For the drugs gave 70 000 rub. and I do not regret it. I will live a full life and raise a 3-year-old daughter. I wish everyone good health!
Guests
Tursunzhan
Hello. I drink for 20 days Sofosbuvir and daklataswir and I feel very good, weakness, lethargy, before lunch I had strength and then all went without power.
Guests
Olga
Good evening! I read everything, but I did not understand how and where to buy a good drug.
Guests
Olena
I have hepatitis C, genotype 1b. I take the second month of sophosbuvir + Daklatasvir. After 12 days of administration, the virus was not detected, liver tests were normal. It helps! Do not be afraid, I bought on the Internet, after reading reviews (the price is $ 380 for the first package and 2 for $ 340). I wish you all good health!
Guests
Victoria
Good evening. I ordered Sofosbuvir and Daklataswir. Original. The drugs went 3-4 days from Novosibirsk to Sakhalin. It cost 70 tr. I was very worried that the doctor would say that the fake is not a fake. Has come on reception, my fears were dispelled. Many thanks to the suppliers.
Guests
Lesya
Who exactly helped this drug? Write please. Very afraid to buy, but need to be treated.
Guests
May
I am treating sophosbuvir and daklatasvir. On day 21, the virus was analyzed for 101n / ml, and it was 8.1 * 10.5 n / ml. So the medicine is good. Production India.
Guests
Dmitriy
I ordered Sophosbuvir from the Indians 6 cans and daklatasvir 6 cans for 24 weeks. 09/15/2016, it came on September 27, 2016 Price with a transfer of 1130 US dollars.
Guests
Andryukha
Hello. People give a normal source, where to order! All the current is praised, what a wonderful drug, but specifically where to turn all silent ...
Administrators
admin
AndryukhaUnfortunately, there are no official supplies and registration of Sofosbuvira in our country yet.Now in Russia you can order various analogues of this drug, especially popular Egyptian origin, there is also Egyptian production. The list of foreign suppliers is presented in a separate article. A link to an article with these sellers is at the end of the product description. There are not checked by me, but people suppliers of these generics to Russia.
Guests
Lyolya
Goodnight. And can you buy this drug yourself in India, is it available for free?
Administrators
admin
LyolyaAs far as I know, to buy generic Sofosbuvira in pharmacies in India, a local doctor's prescription is needed. There is the same pharmacy structure, as in Russia.
Visitors
Flex
When I found out about hepatitis c, I almost fell off the chair, I went to the AIDS center. I realized that there is much that is not needed, crowding, people. The truth is that fibrosis 1, viral activity is low, genotype 3, and the commission will decide whether there is no budget money, so I am for my own, or wait for the queue.You will not draw expensive, from 800 to a million, will rise. They did not say when to come. Called to Moscow, immediately responded within a week to determine the diagnosis, and determine the treatment, the price of the issue 200 000. Then something read about sophosbuvir and daklataswir. In short, I went, I bought vodka, and I was treated for a week, then with beer. And then I decided what could not be avoided. Tied up. He prescribed medicines through the Moscow firm, Indian medicines, the company NATSO. 78 thousand after 5 days with medications, and my personal hepatologist suggested also heptral drink. I drink already the 8th day, while I do not observe all the fine pills. And they also write that they kill the virus, do not show up in the blood, and the antibodies remain, because they remember the virus.
Guests
Lyudmila
I am treated for the 11th week (Sof and Duck). After a month of taking the tests, there is no virus. I ordered from India (coordinates were given by the doctor), wrote off by e-mail, paid. 12 week course - 68500r, courier delivered. Analyzes for antibodies will really show for the presence of the virus, I would like to have no activity. Time will tell, but for now everything is fine.
Guests
Lars
At my friend too a hepatitis With 1 In she bought in Egypt. Went there to see a virologist for a consultation, he explained everything to her, how to take and what tests to take. She bought from them they are licensed and did not worry. Has bought or purchased even superfluous so worried that suddenly will not help or assist. Has passed or has taken place the full course and analyzes good.
Guests
Sergey_46
Hello. For those who ask to tell where to get the drug. Try to solve the problem with the doctor. Not every doctor goes for this, but still. Still, some kind of guarantee.))) I hope. I rummaged through the Internet in search of a solution. A year and a half could not decide what to do. Came here to this. Today I took drugs from a doctor (I think - more expensive than on the Internet) tomorrow I start treatment (Sof and Dak India) 3 months. Hep 1b, F1 is closer to F2 and age 46, besides the man. In general, some cons)))) The load is very high. After 15 days the first analysis. I'll write. Suddenly someone will be useful! Officially in our country you can only die. But you can try not to be cured officially. In any case, a chance. All of health!
Guests
Olga
Now we drink with my husband duck + sofa, background fatigue, nausea, headaches. Analyzes have not yet passed, we drink 20 days. The genotype 3 at me and at the husband, F-0 at me and at the husband F-1.Tired of this condition. Can still what should I drink with these drugs that would improve my health?
Administrators
admin
Olga, Additionally, you can take any hepatoprotectors (Essentiale, Heptral, Ursofalk, Karsil and many others). Deterioration of well-being when taking Daklatasvira with Sofosbuvir is possible, in the future negative symptoms should decrease and completely disappear.
Guests
Tatyana
Good evening. I was offered a course of 12 weeks 200000rub duck + sofa. Who will tell you where to buy cheaper and more reliably? Thank you.
Administrators
admin
TatyanaChecked by the sellers of sellers indicated in a separate article - you can find this list by reference at the bottom of the instruction. You can ask them for a price breakdown on the drugs you need.
Guests
Maslova Antonina
Excellent drugs - 12 weeks of treatment and no pobochek.
Guests
Elena
With hepatitis C 1c, the best drug is sophosbuvir + lepidasvir (Hepcinat LP). Sof. and daklatasvir is better with the 3 genotype.
I pass the course from December 1, 2016g. - genotype 1c - did PCR after 2 weeks of treatment, today the result - RNA is not detected! Hooray!
Guests
Tatyana
I'm just starting to take sophosbuvir + daklataswir. In the effectiveness of drugs I have no doubt, but what about such a large number of pobochki why no one writes about it. Answer, please, is it very difficult to tolerate treatment?
Administrators
admin
Tatyana, All side effects are reflected in the instructions for use of the drug Sofosbuvir. Side effects have accumulated a little, because the drug is new and released in use recently. How to accumulate pobochka for a long time of admission by different groups of patients, then the instruction will be adjusted. So far, I have not heard about the facts of the appearance of serious side effects of taking Sofosbuvir and I have not observed it in patients.
Guests
Victoria
I only recently discovered GEP C, my husband and I were just going to go on vacation in Goa, and then hepatitis. I believe that before the medicine was released to the market, it was tested for many years on a large number of patients and already having positive stable results it was on the market. I have not started treatment yet, the doctor told me that after the month of the virus there will be no more. Let us look forward with optimism, if this rubbish has overtaken us. Happy New Year everyone! All Health!
Visitors
asw
Hello! At me such question: my wife was treated from a genotype 3a with small activity. I took Algeron + Ribavirin. I was treated for 13 weeks instead of 24. I could not stand the abundance of side effects, which not only did not fade with time, but appeared new and were unbearable. Now she feels herself, as if to say, in waves, then she feels good, but it is unbearably bad. Since the cessation of treatment (24,12,2016), it's been three weeks already. Analyzes have not yet been taken. But the other day we'll go to the lab. He takes every day Geptral.

The question is: can it be that with untreated hepatitis he will attack her with more aggressiveness and strength than was before the treatment.What is the risk in this situation? What can you expect from this? Or is it not a planned end of treatment for this does not affect? What can you advise in her case. Thank you in advance! We really hope for your reply and understanding. All the best.
Administrators
admin
asw, Treatment should be completed, and if there are side effects that do not allow continuing the course started, it is necessary to change it to analogues or as an extreme option to switch to other therapy regimens. About the fact that the virus "pounces" with triple power is a fairy tale, just an untreated virus will still take it sooner or later. Perhaps the wife feels so far the result of the side effects of previously taken medicines. To advise I can only address to the attending physician, to hand over analyzes and to look efficiency of an unfinished course of treatment the resulted scheme and activity of a virus. Effective treatment regimens can be found in this topic, but this also requires discussion with the patient's attending physician and sufficient financial resources. Better than Sofosbuvir for the treatment of hepatitis C at the moment is not invented.
Guests
Senya
Hello. People give a normal source, where to order! All the current is praised, what a wonderful drug, but specifically where to turn all silent ...
Guests
Ivan
Dimas, what are you talking about? Hepcinat-Lp does not treat the genotype 3. Does not know, but lies boldly. And can specifically type advertising.
Administrators
admin
Senya, Officially in Russia there is no way. And in the rest, see the link to the article with the sellers above, banners on our site, maybe there will help you with analogues of Sofosbuvira.
Administrators
admin
Ivan, All right. According to the instructions, Hepzinat LP is indicated for the treatment of chronic hepatitis C in adult patients with genotype 1.
Guests
Lezko
Hello. The first week I take sofa + duck + ribavir. Egypt, the cost of 600 dollars. for 12 weeks. Hepatitis C genotype в1. I hope all be fine. Wanted to ask? In the set was the Egyptian oil of black cumin; what is it and how to take it? They say, for the liver. Thank you. Good health.
Guests
ms.nipl
Tell me, please, how to fight with pobochkami, my husband drinks a month sof. + Duck? Terrible headaches, weakness, nasal congestion, cough.
Administrators
admin
ms.nipl, Fighting the side effects of taking medication in most cases is impossible. There are few options - to cancel the drug (and where the alternative is) or replace it with another (I doubt that the former antiviral drugs will cause fewer side effects).
Administrators
admin
LezkoIf anyone knows, let him tell me, I do not know. In our folk medicine, the seed oil of black cumin is not used. And so on the Internet that just do not read about this dietary supplements: and from cancer helps, and stones in the kidneys and gall bladder dissolves, and immunity increases, and vision improves, and the liver protects against viruses. In general, there are many unproven effects. Apparently, doctors or healers from the East should be asked where this exotica is used.
Guests
Olga
Tell me, please, my husband drinks sophosbuvir and daklatasvir for a month, out of side effects fatigue.At the moment he has caught a cold, can he take antiviral drugs, at least rimantadine and sprays for the throat with these drugs?
Administrators
admin
Olga, I can assume that it can take Sofosbuvir and Daklatasvir with the drugs indicated in the question. Remantadine to antiviral drugs, which are meant in the instruction does not apply. There, most likely, described antiviral drugs of other groups for the treatment of hepatitis, which are not included in the already tested and recommended combinations.

But look - the drugs of this group are new, they are tested on patients, because you can not check everything at the stage of clinical trials, many combinations have simply not accumulated a critical mass for sharing, so if something goes wrong immediately, then cancel and run to the doctor.
Guests
Ivan 36
Good day to all! Hepatitis C virus was delivered in 2001. For 16 years I live with this disease. I started treatment with interferons, at that time it was very expensive to be treated and I did not get treatment, I gave up.This muck all the time reminded me of my presence in my life at the level of thoughts. Drank alcohol, trying to drink this grief, then remission, and again constipation. 5 months ago, made a conscious decision to start a new life, in which there is no place for alcohol. He searched for information on the treatment of hepatitis C for a long time, he registered with an infectious diseases specialist. AST 399, ALT 190, the tests are horrible. The doctor prescribed 3 types of treatment, 2 of them interferon, 1 sophos + dac. Because the tests were bad, it was necessary to remove the activity of the virus by ursosan. A month later, the AST fell into three. At friends I went to the infectious disease doctor, the head of the department in the infectious hospital of his city. She accepted me, took responsibility for me, and offered to be treated according to the scheme of sofa + dac. She, through her good friend, brings these preparations from the Indian factory. The course for 3 months cost me 75,000 rubles. I was looking for opportunities, help, to find money for therapy. I have nothing to lose and money, these are only candy wrappers in comparison with health. Today I met her, took the drugs and started the course. Hope, faith, chance, desire to live healthy and clean - this is the main motivation that pushes me not to spare money for it, to make decisions, not to allow doubting the effectiveness.I delegated my will to God in my recovery. You should meet that doctor who will not get welded on your grief, and let you overpay 5,7,10 thousand to the doctor, but it's worth it. After all, there are doctors who are ready to become a part of your life. I wish you all the "cons" in your analyzes, the happiness of being healthy, good and support. God bless you!
Guests
Nicholas77
A good drug helped me! But you should buy on the forums from the sellers (assistants), as the prices are inflated on the sites, and it is unclear for what reason the server can run on gasoline.
Guests
Guzel
1.03.17. I started taking a new drug owls + ice (hetorosofir Plus) Egypt. From pobochek a small headache (tolerable), weakness, more than it was. In general, it is not critical. 29.03. I shall hand over 1 the analysis, we shall look or see result. I am ill or sick since 1998, at present cirrhosis, tk. there is an esophageal vein dilatation, portal hypertension. But for all this fibroscan shows f0_f1. Hepatitis C, genotype 1b. When the result will be achieved.
Guests
Gusel
1.03.17. I started taking a new drug owls + ice.From pobochek a small headache (tolerable), weakness, more than it was. In general, it is not critical. 29.03. I shall hand over 1 the analysis, we shall look or see result. I am ill or sick since 1998, at present cirrhosis, tk. there is an esophageal vein dilatation, portal hypertension. But for all this, fibroscan shows f 0-f 1. Hepatitis C, genotype 1b. When the result will be achieved.

13.03.17. Has handed over biochemistry, the result excellent or different for 13 days. ALT 17; AST 16 such indicators I have not been nearly 20 years, URAaaa.

03.04.17. The result of PCR on the virus will be known.
Guests
Angela
Where can I order these drugs, so as not to be deceived?
Administrators
admin
AngelaWe do not give such consultations. When ordering medicines abroad, everyone should understand the possible risk of sending money to an unknown supplier.
Guests
Vitaliy_N
All of health. I'm 49 from Novorossiysk. There was chronic hepatitis C, stage F3-4 by Metavir and from all the droppers, drinking tablets for all life there was an allergy to all pills. Allergy was expressed in the form of leg cramps at night, as if the legs were being sawed, during the day there was a spasm on the body. The ultrasound from 04.01.17 the size of a liver 190 on 106, in general vylazila.I bought tablets of 3 packs in Krasnodar. sofosbuvir and 3 packs. daclatasvir. A month later passed RNA and the MIRACLE virus was not found. Today I finished taking medication, I took ultrasound in a size 138 to 45 in norm. HOORAY! How many years of suffering. This drug should be sold in pharmacies, but we are all looking for where to buy so that we will not be deceived. In general, guys good luck to you!
Guests
Parvina.Uzbekistan.
Hello. The drug is very good. But for some reason my doctor prescribed only Sofosbuvir without Ribavirin. But although so Sofosbuvir helped me a lot, the indicator of analysis is very good.
Guests
Guzel
03 .04.17. Has handed over analyzes on PTSR, the result the virus is not found out. But owls + ice I drank with ribavirin. Another 2 months must be drunk to finally finish the virus.
Administrators
admin
To the advertisers of the clerks selling Chinese, Indian and Egyptian generics Sofosbuvira I want to say that your advertising does not depend on this topic for a second, it just does not pass the moderation. You can not try. I know perfectly well how you work, and how you profit from sick people.Moreover, official representatives of manufacturers of generic data in Russia simply can not be, because you will not get a license from the Ministry of Health, since the drug is not currently registered in the Russian Federation. Do not take people for a ride.
Visitors
19Maria90
IRINA, Please, tell me, where did you get sophosbuvir?

Ivan 36, Ivan, good evening! Please, if possible, tell me in which city did the doctor help you to buy these drugs? To me they, most likely, too will be necessary, at me 2 weeks ago have found out a hepatitis With. I in horror. I can not eat, sleep, I'm afraid of hugging and kissing a child, I hate myself. I'm not a drug addict, not a prostitute. I live an ordinary life and I will not put my mind where I could stumble. Expensive, of course, are drugs, but this amount is still lifting. Please, you yourself faced such a disaster, help, please, tell me where you can buy these drugs. Thank you very much in advance!
Administrators
admin
19Maria90, First of all you need to calm down,hysterics in the treatment of hepatitis you just will not help, the more it's not an acute infection that needs to be treated siysekundno and the child can be kissed, do not bend.

Secondly, appeals here to visitors are not likely to lead to benefits, because I do not publish advertisements, since we do not carry out expert examination of these proposals.

Several sellers (I placed them free of charge and are not interested in selling their goods), which according to the monitoring results of the forums and reviews to these sales people showed the greatest positive number of responses, are published in the corresponding article (the link to it is at the bottom of the drug card), that's where it costs write and ask about the delivery of generic Sofosbuvira. The risk still remains and it will be until the drug is registered with the Ministry of Health and will not be sold in our pharmacies.
Guests
Lika
Good afternoon. Tell me, what is the probability of one of the spouses to catch from another if a year ago the result was negative?
Administrators
admin
LikaThe sex route of transmission of the hepatitis C virus is low-priority. With unprotected sex, the chance of contracting a spouse is 3-5%. If you are careful - do not use the same personal hygiene items (razors, toothbrushes, etc.), sex occurs with the use of barrier contraception, then the probability of infection is negligible.
Guests
EDWARD
In Russia, Indian drugs for hepatitis C will never be, because it is the development of US pharmacists who sold them a patent with the condition to supply their (Indian) products to 101 developing countries in the world. There are no lists of us in Russia! So do not wait.

Yes, only yesterday came the parcel from India 3 sof and 3 December. With an Indian check there they cost 150 ue for everything. So it's not that expensive 150 bucks per course for 12 weeks. Yes, I do not know with what they are related, they have changed the color of the bubble and in each box the liner that informs about this change.

About drugs (sof ... and duck ...) from doctors and friends heard the current positive feedback (I'll just start taking them). I can say about the old viral therapy in 2012, I personally was not helped, and this is for 1200000 and a year of treatment and all this time is just a terrible condition as if the year was ill with the flu after that I did not want any treatment,full of disappointment and mistrust.
Guests
Igor S
Has drunk sof + dak 10 days, has handed over analyzes, result negative (less than 300, RNA of a virus of a hepatitis C it is not found out or value below a limit of sensitivity of a method
(300 - 1.0 * 10 ^ 8 IU / ml). I continue to drink, after a couple of weeks I will go for more sensitive equipment, where it will show whether or not, or less than 15. They said that we do not have more accurate, there are no analyzers for 100 percent.
Visitors
ajrby
Hello. Began to take sophosbuvir (hepcinat) + daklatosvir (natdac). Bought on the advice of a doctor. After the first reception at 6 am, by the middle of the day an allergic reaction. Redness of the skin, hives. Breathing is normal (does not throttle). Whether it is possible to continue reception? There are still no other options for treatment. So far he has taken suprastin. Thank you.
Administrators
admin
ajrbyTaking into account the importance of therapy, treatment according to the proposed scheme can be continued. Although knowing the delivery mechanisms of these medicines, buying counterfeit and other sabotage in deliveries can not be ruled out, but you will not be able to check this now,drugs are not registered on the territory of Russia and other former Soviet republics.
Visitors
Alexander121
I, when a doctor diagnosed hepatitis C, was very upset with me, because I knew that the disease was not completely treated, and even if some progress was achieved in the treatment, the disease still flows in a slow regime. But the doctor hastened to calm me and said that for today hepatitis C is treated with drugs, which include Sofosbuvir. Drinking the full course of medicine recommended by the doctor, I really got rid of this disease completely.
Administrators
admin
Various stores of questionable content and the origin of generics Sofosbuvira in the reviews are not published. You can not try, gentlemen, advertisers. All your veiled promotional offers are sent to the urn.
Guests
EDWARD
Has handed over the analysis on ptsr after 4 weeks after reception sof + dak result negative. I ordered it via the Internet.Compiled the contract in electronic form. You could have contacts, but you will not be moderated. People search the Internet for everything there, only more attentively. See the reviews check counterparties in the state register.
Visitors
ajrby
I already wrote about allergies. Two days later passed. After two weeks, the tests are in order. In general, everything. I continue to accept. I donate blood. Apparently the supplier is all right. It seems to me to buy it only through a hepatologist.
Guests
EDWARD
How do you think airby, and where they get a hepatologist? My hepatologist said that in her practice she had never before, that these medicines did not help, no one else had been treated with a fake, but everything happens for the first time. She does not trade this with a medicine, before all advised natko, tk. they began to sell to Egypt, Pakistan and other countries where they were allowed by the Americans, but then ceased to advise anyone because the people in other companies took the same results, and the price is lower.
Guests
Irina
Hello. Tell me,Can I take hormone pills with sof and duck? My husband and I started to drink a three-month course today, and before that the gynecologist prescribed me 6 months to drink hormones. I can not find anywhere about the compatibility of drugs.
Administrators
admin
Irina, And you will not find. This information is practically non-existent, because the statistics on interaction is collected only in the countries of official sales of Sofosbuvira and Daklatasvira. Russia and the countries of the former socialist camp are not on the sales list at all. And since the drug is new and any additional information on sharing with hormones you are unlikely to find, even from the official manufacturer. I in such cases look, what disease is more priority, it or him and we treat, and the rest then. Or if they start taking hormonal drugs, then we are cured by them, and then we take Sofosbuvir (although hepatitis will be more important than any illnesses). And when using together, you have to understand that you are going to risk.
Guests
Edward
Good day. I want to say that my doctor strictly forbade me to take any medications with these drugs and even herbs such as crap, etc.And these preparations do not drink two together, but drink them one at the beginning of the meal, and the other at the end of the meal, 15 minutes later. But at the same time, other meals when you do not drink sofa + dak allowed to take medications (if you take ) which produce enzymes (although I do not accept them). Completely trusted her and do it. For 7 and a half weeks of taking medication, there were no side effects, except for an easy "ballydock". And even within 2 hours after the reception, she was forbidden to go to bed, she said something to do best, walk around, play with the children. I drink medicine over dinner at the same time.
Guests
Lesha
Guys, forgot to drink on the 28th day of the pill. He remembered and drank in 12 hours. Is it critical? I'm worried terribly!
Guests
Olga
I learned about these miracle preparations today in the transfer of health. If I'm not mistaken, they were talking about 10-15 tons, why they advertise if they do not. How much do you think will take time to appear with us? It is very insulting to buy in the pharmacy could have many, and so on maybe give a lot of money.Hepatitis since 2008, gave birth to a child this year, I'm very much afraid that this baby will show up this muck, but they said to check after a year only. While writing a positive (((
I really hope for the best. And can you say how much you can live with this disease? Now to me 29.
Administrators
admin
OlgaIf the process is inactive, hepatitis C can survive as much as potentially without this disease. And you can go out after a couple of years on fibrosis-cirrhosis of the liver and that's it. It's like a mine in the body, it can work, maybe it does not.

Russia is a country specific in terms of medical care. Here sometimes the laws of formal logic do not work or are subject to narrow production-oligarchic interests, plus total poverty of what concerns medical support (apparently, there is much to spend money for). In general, one policy and no economy or care for patients. Therefore, the affirmative answer to the question that the drug Sofosbuvir will be resolved to free sale through official channels can not. On the other hand, if we have the official Sofosbuvir available (the drug is still under patent protection), not many of the patients will be able to buy this expensive drug.Russia does not belong to third world countries in the understanding of Western pharmaceutical companies, so the production of cheap generics Sofosbuvira and compulsory licensing here will not work.

Lesha, Nothing wrong. If 12 hours from the required time, we can say that we had time.
Guests
Irena
I drink sophosbuvir with daklatasvir, and for the main disease tamoxifen for 6 weeks already. After 4 weeks, the result is negative, pobochki - usual: headache, weakness, hot flashes, skin rashes. Currently, the allergic reaction of the genitals is concerned (sorry for intimate details).
Guests
Irina
She took 12 weeks of sophoswell (sophosbuvir + velpathaswir, India) and ribavirin. The virus is not found after two weeks of taking the drug. Biochemistry also came back to normal. From pobochek: on the first day by the evening the head fell ill, the night did not sleep well, the muscles ached, like with a cold, woke up with a sore throat and an aching in the body. The next day I got up, as usual. All. There were no more manifestations. Be sure to drink water throughout the day.At the moment, three months have passed since the treatment, the virus is not detected. Get treated, friends. Hepatitis is not a joke.
Guests
kobyzev1
Not for the first time I heard that foreign drugs are much better than domestic analogues. But it was not possible to buy, after all they are not cheap. I had to dig up some money to buy the whole course right away. Thanks to my beloved doctor, advised me to combine the two drugs, since the case I had was neglected, the initial stage of cirrhosis. Has bought or purchased cimivir (sophosbuvir) and dacihep (daklatasvir). Delivered very quickly - in two weeks. Well, efficiency is beyond praise - I was cured. God, he's been tormented for so many years. I wish that you will succeed too!
Guests
Strawberry_21
My friend was in Egypt, I brought from there myself a course for 12 weeks of cofosbuvir + daklatasvir, I could not take it out - restrictions on the number of tablets at the customs. The price for this was 12,000. I bought here for 25. I compared all the boxes of the tablet - one to one. We started treatment. And the doctor told me 150,000. I was shocked when I found out how much they are profiting from us.
Guests
Valerie12
Valerie12, Moved your question to the drug Daklatasvir, where it is more appropriate.
admin
Guests
Zakaraia lamzira
We have free of charge this program in Georgia because this is the country where the most infected with hepatitis C and our president won the tender. My mother since 2008 is sick with hepatitis C. This year we began to be examined and stood up for this program. Her diagnosis is now grade 3 fibrosis. Treatment of 12 weeks, and then we will take tests. 65 to my mother. And this medicine now costs 200,000 dollars per course for three months 90 tablets. I want to say that people from Armenia and Russia come here and make citizenship to undergo this treatment. It's true.

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