Kompligam B - instructions for use, reviews, analogs and forms of release (injections in ampoules for injection 2 ml, tablets Complex) drugs for the treatment of neuritis, neuralgia, paresis and lumbago in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Compliments B. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Compligam in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Compligam B in the presence of existing structural analogs. Use to treat neuritis, neuralgia, paresis and lumbago in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Kompligam B - a combined preparation containing Vitamins of group B and lidocaine.

Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the peripheral nervous system and motor apparatus. In high doses have analgesic properties, promote blood flow, normalize the work of the nervous system and hemopoiesis processes (vitamin B12).

Thiamine (vitamin B1) plays a key role in the processes of carbohydrate metabolism that are crucial metabolic processes in nervous tissue and in the Krebs cycle with subsequent participation in the synthesis of thiamine pyrophosphate and ATP.

Pyridoxine (vitamin B6) is involved in the metabolism of proteins, and in part, in the metabolism of carbohydrates and fats.

The physiological function of both vitamins (B1 and B6) is the potentiation of each other's action, manifested in a positive effect on the nervous, muscular and cardiovascular systems.

Cyanocobalamin (vitamin B12) involved in the synthesis of the myelin sheath, stimulates hematopoiesis, reduces pain associated with lesions of the peripheral nervous system, stimulates nucleic exchange via folate activation.

Lidocaine is a local anesthetic that causes all kinds of local anesthesia.

Composition

Thiamine hydrochloride (vitamin B1) + Pyridoxine hydrochloride (vitamin B6) + Cyanocobalamin (vitamin B12) + Lidocaine hydrochloride + excipients.

Pharmacokinetics

After intramuscular injection, thiamin is rapidly absorbed from the injection site and enters the blood and is distributed unevenly in the body (its content in leukocytes is 15%, erythrocytes - 75% and in blood plasma - 10%). In connection with the lack of significant vitamin stores in the body, it must enter the body daily. Thiamin penetrates the blood-brain barrier (GEB) and placental barrier, excreted in breast milk.

After intravenous injection, pyridoxine is quickly absorbed into the bloodstream and distributed in the body, acting as a coenzyme after phosphorylation of the CH2OH group in the 5-th position. About 80% of pyridoxine binds to blood plasma proteins. Pyridoxine is distributed throughout the body, penetrates through the placental barrier, excreted in breast milk.

The main metabolites are: thiaminic acid, pyramine and some unknown metabolites.Of all the vitamins, thiamine is retained in the body in the least amount. The adult body contains about 30 mg of thiamine in the form of thiamine pyrophosphate (80%), thiamine triphosphate (10%) and the rest in the form of thiamine monophosphate. Pyridoxine is deposited in the liver and oxidized to 4-pyridoxic acid.

Thiamine is excreted in the urine in the alpha phase after 0.15 h, in the beta phase - after 1 h and in the terminal phase - for 2 days. 4-pyridoxic acid is excreted in the urine, a maximum of 2-5 hours after absorption. In the human body contains 40-150 mg of vitamin B6, its daily elimination rate is about 1.7-3.6 mg at a replenishment rate of 2.2-2.4%.

Indications

For pathogenetic and symptomatic therapy of diseases and syndromes from the nervous system of various origin:

• Neuropathy and polyneuropathy (diabetic, alcoholic and others);
• neuritis and polyneuritis, incl. retrobulbar neuritis;
• peripheral paresis, incl. facial nerve;
• neuralgia, incl. trigeminal nerve and intercostal nerves;
• pain syndrome (radicular, myalgia);
• nocturnal muscle cramps, especially in older age groups;
• plexopathy, ganglionitis (including herpes zoster);
• neurological manifestations of osteochondrosis of the spine (radiculopathy, lumboeishalgia, muscular-tonic syndromes).

Forms of release

Solution for intramuscular injection (injections in ampoules for injection 2 ml).

Tablets (Complymgam B Complex).

Instructions for use and dosing regimen

In severe pain syndrome, it is advisable to begin treatment with intramuscular injection (deep) 2 ml of the drug daily for 5-10 days with a transition in the future either for oral administration or for rarer injections 2-3 times a week for 2-3 weeks .

Side effect

• skin reactions in the form of itching, hives;
• reactions of hypersensitivity to the drug, incl. rash, shortness of breath, angioedema, anaphylactic shock;
• increased sweating;
• tachycardia;
• acne.

Contraindications

• severe and acute forms of decompensated chronic heart failure;
• children's age (due to lack of research);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

It is not recommended to use the drug Compligam B during pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in childhood use (due to lack of research).

special instructions

In cases of very rapid administration of the drug, it is possible to develop systemic reactions (dizziness, arrhythmia, convulsions).

Impact on the ability to drive vehicles and manage mechanisms

Information about caution regarding the use of the drug by drivers of vehicles and persons working with potentially dangerous mechanisms is not available.

Drug Interactions

Pyridoxine is not prescribed concomitantly with levodopa, since the effect of the latter is weakened.

Taking into account the presence of lidocaine in the composition of the drug, in case of additional use of epinephrine and norepinephrine, there may be an increase in side effects on the heart. In case of an overdose of local anesthetics, epinephrine and norepinephrine should not be used additionally.

Pharmaceutical interaction

Thiamin completely dissolves in solutions containing sulfites.

Thiamine is unstable in alkaline and neutral solutions; the appointment with carbonates, citrates, barbiturates, copper preparations is not recommended.

Cyanocobalamin is incompatible with ascorbic acid, salts of heavy metals.

Analogues of the drug Compligam B

Structural analogs for the active substance:

• Binavit;
• Vitagamma;
• Vitaxon;
• Kompligam B Complex;
• Milgamma;
• Trigamma.

Analogues for the pharmacological group (vitamins and vitamin-like drugs):

• Aevit;
• Angiovitis;
• Antioxidants;
• Ascorutin;
• Aerovit;
• Berocca calcium and magnesium;
• Berrocka Plus;
• Biotredin;
• Vitaxon;
• Vitamax;
• Vitaspectrum;
• Vitrum;
• Hexavit;
• Gendevit;
• Heptavit;
• Gerimax;
• Jungle;
• Duovit;
• Calcevit;
• Calcium D3 Nycomed;
• Calcium D3 Nicomed Forte;
• Kaltsinov;
• Kombilipen;
• Complivit;
• Materna;
• Menopace;
• Multitabs;
• Multimax;
• Neurobion;
• Neurogamma;
• Neurodiclavitis;
• Neuromultivitis;
• Oligovit;
• Pantobrigger;
• Pentovit;
• Pikovitz;
• Polinevrin;
• Pregnacea;
• Revitalize;
• Sana-Sol is a multivitamin complex;
• Selmevit;
• Supradin;
• Teravit;
• Tetravit;
• Trigamma;
• Triovit;
• Undevit;
• Pharmaton Vital;
• Centrum;
• Cernevit;
• Unigamma.

Similar medicines:

Other medicines: