Milgamma - instructions for use, reviews, analogs and forms of release (tablets (pills), injections (ampoule injections)) of a vitamin-based drug for the treatment of osteochondrosis, neuralgia in adults, children and pregnancy

In this article, you can read the instructions for using the drug Milgamma. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Milgamma in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Milgamma in the presence of existing structural analogs. Use for the treatment of osteochondrosis, neuralgia and other neurological diseases in adults, children, as well as during pregnancy and lactation.

Milgamma - complex preparation on the basis of Vitamins of group B. Neurotropic vitamins of group B have a favorable effect on inflammatory and degenerative diseases of nerves and motor apparatus. Promotes increased blood flow and improves the functioning of the nervous system.

Thiamine (vitamin B1) plays a key role in the metabolism of carbohydrates, as well as in the Krebs cycle with subsequent participation in the synthesis of TPI (thiamin pyrophosphate) and ATP (adenosine triphosphate).

Pyridoxine (vitamin B6) is involved in protein metabolism and, in part, in the metabolism of carbohydrates and fats.

The physiological function of both vitamins is the potentiation of each other's action, manifested in a positive effect on the neuromuscular and cardiovascular systems. With a deficiency of vitamin B6, widespread deficit conditions quickly stop after the administration of these vitamins.

Cyanocobalamin (vitamin B12) involved in the synthesis of the myelin sheath, stimulates hematopoiesis, reduces pain associated with lesions of the peripheral nervous system, stimulates nucleic exchange via folate activation.

Lidocaine is a local anesthetic that causes all kinds of local anesthesia (terminal, infiltration, conductive).

Pharmacokinetics

After intramuscular injection, thiamin is rapidly absorbed and enters the blood.

After intramuscular injection, pyridoxine is rapidly absorbed into the systemic circulation and distributed in the body.

Thiamine is distributed unevenly in the body. Thiamine content in leukocytes is 15%, in erythrocytes - 75% and in plasma - 10%. In connection with the lack of significant vitamin stores in the body, it must enter the body daily. Thiamine passes through the BBB and the placental barrier and is found in breast milk.

Pyridoxine is distributed throughout the body, it penetrates the placental barrier and is found in breast milk.

Thiamine is excreted in the urine. Pyridoxine is deposited in the liver and oxidized to 4-pyridoxic acid, which is excreted in the urine, maximum 2-5 hours after absorption.

Indications

As a pathogenetic and symptomatic agent in the complex therapy of diseases and syndromes of the nervous system of various origins:

• neuralgia, neuritis;
• paresis of the facial nerve;
• retrobulbar neuritis;
• ganglionitis (including herpes zoster);
• plexopathy;
• neuropathy;
• polyneuropathy (diabetic, alcoholic);
• nocturnal muscle cramps, especially in older age groups;
• neurological manifestations of osteochondrosis of the spine;
• radiculopathy;
• sciatica;
• muscular-tonic syndromes.

Forms of release

Solution for intramuscular injection in injections (ampoules) of 2 ml.

Tablets (pills) 100 mg + 100 mg.

Milgamma compositum (dragees) 100 mg + 100 mg.

Instructions for use and dosing regimen

Solution

In cases of severe pain, it is advisable to start treatment with intramuscular injection of the drug in a dose of 2 ml every day for 5-10 days, with a transition in the future either for oral administration or for a less frequent administration (2-3 times a week for 2-3 weeks ) with the possible continuation of therapy with the oral dosage form.

The drug is injected deep in the / m.

Dragee

Assign 1 dragee to 3 times a day for 1 month.

The drug should be taken with a sufficient amount of fluid.

Side effect

• itching, urticaria;
• labored breathing;
• angioedema;
• anaphylactic shock;
• increased sweating;
• tachycardia;
• acne.

Contraindications

• Decompensated heart failure;
• children's age (due to lack of data);
• increased individual sensitivity to the components of the drug.

Application in pregnancy and lactation

During pregnancy and lactation, the use of the drug is not recommended.

Use in children

Contraindicated the appointment of the drug to children (not enough clinical data for this group of patients).

Drug Interactions

Thiamin is completely destroyed in solutions containing sulfites.

Other vitamins are inactivated in the presence of the decomposition products of B vitamins.

Levodopa reduces the effect of pyridoxine.

Possible interaction of the drug with cycloserine, D-penicillamine, epinephrine, norepinephrine, sulfonamides, which leads to a decrease in the effect of pyridoxine.

Thiamin is incompatible with oxidizing substances, mercuric chloride, iodide, carbonate, acetate, tannic acid, iron-ammonium citrate, as well as phenobarbital, riboflavin, benzylpenicillin, Dextrose and metabisulphite.

Thiamine loses its effect with increasing pH (more than 3).

Indifferent to alcohol intake (does not affect the metabolism of the drug).

Analogues of Milgamma

Structural analogs for the active substance:

• Binavit;
• Vitagamma;
• Kombilipen;
• Complymgam;
• Trigamma.

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