Panzef - instructions for use, reviews, analogs and forms of release (pellets for the preparation of 100 mg suspension, 400 mg tablets) for the treatment of angina, sinusitis, otitis in adults, children and pregnancy. Composition of antibiotic

In this article, you can read the instructions for using the drug Panzef. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of antibiotic Panzef in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Pantsef analogs in the presence of existing structural analogs.Use for the treatment of angina, sinusitis, otitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Panzef - Semisynthetic cephalosporin antibiotic 3 generation for oral administration in a wide spectrum of action. It is bactericidal. The mechanism of action is due to the inhibition of the synthesis of the cell membrane of the pathogen. Cefixime (the active substance of the drug Pansef) is resistant to the action of beta-lactamases produced by most gram-positive and gram-negative bacteria.

Panzef is active against gram-positive bacteria: Streptococcus agalactiae (streptococcus); Gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Protivosa spp., Salmonella spp. (salmonella), Shigella spp. (Shigella), Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; Gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli (E. coli), Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes (listeria), most Staphylococcus spp. Are resistant to cefixime. (Staphylococcus aureus) (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Composition

Cefixime + excipients.

Pharmacokinetics

When administered, the bioavailability of Panzef is 40-50% regardless of food intake. The binding with plasma proteins, mainly with albumins, is 65%. About 50% of the dose is excreted in the urine unchanged for 24 hours, about 10% of the dose is excreted with bile.

Indications

Infectious-inflammatory diseases (acute and chronic) caused by sensitive microorganisms:

• pharyngitis;
• angina;
• tonsillitis;
• pharyngitis;
• tracheitis;
• laryngitis;
• sinusitis (sinusitis);
• acute and chronic bronchitis;
• purulent otitis media;
• uncomplicated urinary tract infections (cystitis, urethritis);
• prostatitis;
• uncomplicated gonorrhea.

Forms of release

Granules or powder for the preparation of a suspension for ingestion 100 mg.

The tablets covered with a cover of 400 mg.

Instructions for use and dosage

Pills

For adults and children over 12 years of age with a body weight of more than 50 kg, the daily dose is 400 mg (once a day or 200 mg twice a day). The duration of the course of treatment is 7-10 days. With uncomplicated gonorrhea - 400 mg once.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of violations of kidney function (with CC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

Suspension

Children aged 6 months to 12 years, weighing less than 50 kg, the drug is prescribed as a suspension at a dose of 8 mg / kg once a day or 4 mg / kg every 12 hours.

The average duration of treatment is 7-10 days.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days. Due to the difference in bioavailability, the suspension is not recommended to be replaced with tablets.

Method of preparation 60 ml suspension for ingestion 100 mg / 5 ml

The suspension is prepared immediately before the first use. Vial shake several times. Using a measuring cap, add 40 ml of boiled water cooled to room temperature in 2 stages and shake vigorously after each addition until a homogeneous suspension forms.

Method of preparation 100 ml suspension for ingestion 100 mg / 5 ml

The suspension is prepared immediately before the first use. Vial shake several times. With a cap, add 66 ml of boiled water cooled to room temperature in 2 stages and shake vigorously after each addition until a homogeneous suspension forms.

To dispense the finished suspension, a measuring cap should be used, which should be rinsed well with water after each use.

Before use, the prepared suspension should be shaken well.

You can store the finished suspension of antibiotic Panzef in the refrigerator for no more than 12 hours, after cooking.

Side effect

• dry mouth;
• anorexia;
• diarrhea;
• nausea, vomiting;
• stomach ache;
• flatulence;
• jaundice;
• Candidiasis of the gastrointestinal tract;
• dysbiosis;
• stomatitis, glossitis;
• pseudomembranous enterocolitis;
• leukopenia, thrombocytopenia, neutropenia, hemolytic anemia;
• dizziness;
• headache;
• interstitial nephritis;
• itching;
• hives;
• hyperemia of the skin;
• eosinophilia;
• fever.

Contraindications

• increased sensitivity to cephalosporins and penicillins.

Application in pregnancy and lactation

Use in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

Use in children

With caution should be used in children under 6 months.

Application in elderly patients

Caution should be used in elderly patients.

special instructions

Caution should be used in elderly patients, patients with chronic renal failure or pseudomembranous colitis (in the anamnesis), in children under 6 months.

With prolonged use, there may be a violation of normal intestinal microflora, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

In patients with a history of allergic reactions to penicillins, there may be manifestations of hypersensitivity to cephalosporin antibiotics.

During treatment, a positive direct Coombs reaction and a false positive urine reaction to glucose are possible.

Drug Interactions

Against the background of the joint administration of Cefixime and Warfarin, the effect increases, the probability of bleeding increases.

Against the background of the joint administration of Cephixime and carbamazepine, the plasma level increases.

Ectric acid increases (mutually) the likelihood of developing nephro- and ototoxicity.

Analogues of the drug Pantsef

Structural analogs for the active substance:

• Ixim Lupine;
• Supraks;
• Supraks Solutab;
• Cemidexor;
• Ceforal Solutab;
• Cefspan.

Analogues on the pharmacological group (antibiotics of cephalosporins):

• Azaran;
• Alfacet;
• Anceph;
• Biotrakson;
• Boncefin;
• Witsef;
• Duracif;
• Zefter;
• Zinatsef;
• Zinnat;
• Zinforo;
• Iphietz;
• Ketoceph;
• Kefotex;
• Claforan;
• Clafotaxime;
• Liphoran;
• Longacef;
• Maksipim;
• Maksitsef;
• Megion;
• Medaxone;
• Nacef;
• Opexin;
• Proxim;
• Rocefin;
• Soleksin;
• Spectraceph;
• Sulperazone;
• Sulceph;
• Supraks;
• Tertsef;
• Totatsef;
• Forcef;
• Chizon;
• Tzedek;
• Cefabol;
• Cefazolin;
• Cefaxon;
• Cephalexin;
• Cephezole;
• Cefepime;
• Cefoxytin;
• Cefoperazone;
• Ceforal Solutab;
• Cefotaxime;
• Ceftazidime;
• Ceftriaxone;
• Cefurabol;
• Cefuroxime;
• Etipim.

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