Cefodox - instructions for use, reviews, analogs and formulations (tablets 100 mg and 200 mg, powder for the preparation of a suspension or antibiotic syrup) of a drug for treatment of angina, bronchitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Cefodox. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of antibiotic Cefodox in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cefodox in the presence of existing structural analogues.Use for the treatment of angina, bronchitis, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Cefodox semisynthetic antibiotic. Refers to the third generation of cephalosporin drugs. The bactericidal action of Cephodox is due to its ability to acetylate membrane transpeptidases of the cell wall of microorganisms. As a result, the formation of cell walls of fissile microorganisms is disrupted.

Many gram-negative microorganisms (Proteus mirabilis (proteus), Klebsiella spp. (Klebsiella), Haemophilus influenzae, Escherichia coli (Escherichia coli), Citrobacter spp.,, Providencia spp., Serratia spp., Pseudomonas spp.) Are sensitive to Cefodox. Gram-positive microorganisms - Streptococcus spp. (streptococcus), Neisseria meningitidis, Staphylococcus spp. (Staphylococcus aureus), Bacteroides spp, Neisseria gonorrhoeae.

Anaerobes are insensitive.

Most strains of enterococci, clostridia, mycoplasmas, legionella, chlamydia, methicillin-resistant strains of staphylococci are insensitive. Cefpodoxime is not destroyed by beta-lactamases of gram-negative bacteria.

Composition

Cefpodoxime + excipients.

Pharmacokinetics

In the digestive tract, the drug is well absorbed.Bioavailability is about 52%. It is distributed in most tissues and body secrets. Accumulated in the lungs, muscles, liver, kidneys, bones. Penetrates through capsules of abscesses and into cerebrospinal fluid. In the body, cefpodoxime is not metabolized. Excreted by the kidneys.

Indications

Infectious processes caused by microflora, sensitive to Cefodox:

• sinusitis (sinusitis);
• tonsillitis (tonsillitis);
• otitis;
• laryngitis;
• pharyngitis;
• bronchitis;
• pneumonia (with severe forms of disease - after the effect of therapy with parenteral drugs);
• cystitis;
• pyelonephritis (of mild or moderate severity);
• infections of the skin, joints, bones, soft tissues;
• urethritis;
• proctitis;
• cervicitis of gonococcal etiology.

Forms of release

Tablets coated with 100 mg and 200 mg.

Powder in bottles of 50 ml for the preparation of a suspension (pediatric practice) (sometimes mistakenly called syrup).

Instructions for use and dosing regimen

The daily dose of Cefodox for adults and adolescents over 12 years is 200-400 mg (for infections of the VDP and urinary tract - 200 mg, with pneumonia and / or bronchitis - 400 mg).

Children, starting from the age of 5 months,Cefodox is administered at a daily dose of 10 mg / kg.

The drug is taken at the same time as eating. The interval between doses is 12 hours.

With severe renal dysfunction (creatinine clearance less than 40 ml per minute), a single dose of Cefodox is halved.

Side effect

• nausea, vomiting;
• abdominal pain;
• diarrhea;
• dyspepsia;
• headache;
• allergic reactions of intolerance;
• itching;
• transient rashes;
• increased plasma creatinine and urea levels;
• eosinophilia.

Contraindications

• hypersensitivity to the drug.

Application in pregnancy and lactation

It is possible to use the antibiotic Cephodox, taking into account the intended use for the mother and possible complications for the embryo or fetus.

Use in children

It is possible to use Cefodox as a suspension in children, starting at the age of 5 months (at a daily dose of 10 mg / kg).

special instructions

The finished suspension can be stored at a temperature of + 4-6 degrees Celsius (in the refrigerator) for no more than 14 days.

Perhaps the appearance of a positive Coombs reaction.

It should be borne in mind the possible development of dysbiosis and superinfection (usually with prolongedappointment).

Drug Interactions

Absorption of the drug reduces antacids and H2-receptor blockers.

With the simultaneous administration of nephrotoxic drugs, control of kidney activity is necessary.

Oral anticholinesterase agents increase the intensity of antibiotic absorption.

Analogues of the drug Cephodox

Structural analogs for the active substance:

• Orelox;
• Sephpotek.

Analogues for the pharmacological group (cephalosporins):

• Azaran;
• Aksetin;
• Alfacet;
• Anceph;
• Bakperazone;
• Biotrakson;
• Boncefin;
• Witsef;
• Zefter;
• Zinatsef;
• Zinforo;
• Iphietz;
• Keiten;
• Claforan;
• Clafotaxime;
• Ksorim;
• Longacef;
• Medaxone;
• Nacef;
• Orelox;
• Ortaxime;
• Opexin;
• Palitrex;
• Panzef;
• Proxim;
• Rocefin;
• Soleksin;
• Sulperazone;
• Supraks;
• Supraks Solutab;
• Tazyceph;
• Tertsef;
• Felaxin;
• Cefabol;
• Cefazolin;
• Cephalexin;
• Cefaprim;
• Cefepime;
• Cefoxytin;
• Cefoperazone;
• Cefosin;
• Cefotaxime;
• Ceftazidime;
• Ceftriabal;
• Ceftriaxone;
• Cefurabol;
• Cefuroxime;
• Cef;
• Ecocephron;
• Etipim.

Similar medicines:

Other medicines: