Sustanon 250 - instructions for use, reviews, analogs and forms of release (injections in ampoules for injections in solution) for the treatment of impotence, osteoporosis and other manifestations of hormone deficiency in androgens in men. Composition

In this article, you can read the instructions for using the drug Sustanon 250. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Sustanon 250 in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Sustanon 250 in the presence of existing structural analogs.Use for the treatment of impotence, osteoporosis and other manifestations of hormone deficiency in androgens in men. Composition of the preparation.

Sustanon 250 - leads to a clinically significant increase in the concentrations of testosterone, dihydrotestosterone, estradiol and androstenedione in plasma, as well as a decrease in the level of SHBG (globulin binding sex hormones); The levels of luteinizing hormone (LT) and follicle-stimulating hormone (FSH) are restored to normal values.

Testosterone is the main endogenous hormone irreplaceable for normal growth and development of male genital organs and male secondary sexual characteristics. During the life of adult men, testosterone is indispensable for the functioning of the testes and accompanying structures, as well as for maintaining libido, well-being, erectile potency and for the function of the prostate gland and seminal vesicles.

Treatment with the drug Sustanon-250 leads to a reduction in symptoms of testosterone deficiency. In addition, the mineral density of bones and muscle mass increases, in obese patients, weight loss occurs.In the course of treatment, sexual functions are normalized, including erectile function and libido. When the drug is used, serum concentrations of HDL (high-density lipoprotein), low-density lipoprotein (LDL) and triglycerides are reduced, hemoglobin concentrations and hematocrit are increased, but there is no clinically significant change in the level of hepatic enzymes and PSA (prostatic specific antigen). The drug can cause an increase in the size of the prostate gland, with no functional changes noted. In hypogonadal men with diabetes, the use of androgens improves insulin sensitivity and / or reduces the concentration of glucose in the blood plasma.

In boys with delayed growth and puberty, the use of androgens accelerates growth, stimulates the development of secondary sexual characteristics.

Treatment of transsexual women with androgens, as with Sustanon 250, promotes masculinization.

Composition

Testosterone propionate + Testosterone phenylpropionate + Testosterone isocaproton + Testosterone decanoate + excipients.

Pharmacokinetics

The drug Sustanon 250 contains a number of testosterone esters with different duration of action. These ethers, after entering the circulating blood, immediately hydrolyzed into the natural hormone testosterone. A single dose of the drug leads to an increase in total testosterone in the plasma. In men, testosterone levels return to the lower limit of the norm in about 21 days. The tests show a high degree of non-specific binding to plasma proteins of testosterone (more than 97%) and with SHBG. Testosterone is metabolized to dihydrotestosterone and estriol naturally. It is excreted mainly with urine in the form of conjugates of etiocholanolone and androsterone.

Indications

• post-stroke syndrome;
• eunuchoidism;
• hypopituitarism;
• endocrine impotence;
• Menopausal disorders in men (including decreased libido, mental and physical activity);
• osteoporosis, caused by a deficiency of androgens.

Forms of release

Solution for intramuscular administration oily (injections in ampoules for injection).

There are no other dosage forms, be it pills or capsules.

Instructions for use and course of admission

Intramuscularly, deep into the muscle.The dosage regimen is selected in accordance with the individual reaction; as a rule, 1 ml every 3 weeks.

Side effect

• prostate cancer (or worsening of the course of diagnosed prostate cancer);
• polycythemia;
• fluid retention (edema);
• depression;
• increased nervous excitability;
• mood change;
• increased or decreased libido;
• myalgia;
• increased blood pressure;
• nausea;
• itching;
• acne;
• gynecomastia;
• oligospermia;
• decreased ejaculate volume;
• priapism;
• functional disorders of the prostate (hypertrophy);
• abnormal liver function;
• hypercalcemia.

After the cancellation of Sustanon, side effects persist for some time.

Injections can cause a local reaction at the injection site (pain, itching, congestion).

Contraindications

• established or suspected prostate or breast cancer;
• hypersensitivity to any component of the drug;
• children under 3 years (in connection with the content of benzyl alcohol).

Application in pregnancy and lactation

This drug is contraindicated during pregnancy.

There is insufficient data on the use of this drug during breastfeeding.

Use in children

It is contraindicated to prescribe this drug to children under 3 years old.

With caution use this drug in children older than 3 years.

With caution: in boys in the prepubertal period in order to avoid premature closure of the epiphyses and premature puberty.

special instructions

With caution use the drug Sustanon 250 in boys in the prepubertal period in order to avoid premature closure of the epiphyses and premature puberty; chronic heart failure, renal and / or liver failure to avoid edema development; diabetes; hypertrophy of the prostate with symptoms of urinary retention; sleep apnea, and risk factors such as obesity and chronic lung disease; childhood.

There should be medical supervision of patients receiving Sustanon 250, before treatment and quarterly for 12 months and subsequently 1 time per year.

The following studies should be carried out:

• digital rectal examination (PRI) to exclude benign prostatic hyperplasia (see in the same sentence) and the definition of a specific prostate antigen (PSA) to exclude subclinical forms of prostate cancer.
• Measurement of hematocrit and hemoglobin to exclude polycythemia.

In patients with a previously existing pathology of the heart, kidneys or liver, treatment with androgens can cause complications characterized by edema with or without acute heart failure.

In case of undesirable reactions associated with the use of androgens, treatment with Sustanon 250 should be temporarily interrupted, and after the disappearance of symptoms resume at a lower dose.

The use of androgens is not for the intended purpose, but for increasing endurance in athletes, poses serious health risks. The use of androgens, including Sustanon 250, in elderly patients increases the likelihood of developing hypertrophy or prostate cancer.

Many young people use the drug as a dope to increase muscle mass in bodybuilding and exercise in the gym.However, the possible occurrence of side effects with this method raises the question of whether the drug Sustanon 250 should be used in healthy people.

Impact on the ability to drive vehicles and manage mechanisms

Until now, there has been no report on any effect on the concentration of attention and the speed of psychomotor reactions when using Sustanon 250.

Drug Interactions

Medicines that induce or inhibit enzymes can accordingly reduce or increase the concentration of testosterone. Therefore, dosage and / or interval between injections may need to be adjusted.

Androgens can increase glucose tolerance and reduce the need for insulin or other hypoglycemic drugs in people with diabetes.

High doses of androgens can enhance the action of anticoagulants of the coumarin type, which allows reducing the doses of these drugs.

Analogues of the drug Sustanon 250

Structural analogs for the active substance:

• Andriol;
• Androgel;
• Nebido;
• Omnadren 250;
• Testosterone propionate;
• Test for injection 10%.

Analogues for the pharmacological group (androgens and antiandrogens):

• Avodart;
• Alfinal;
• Anandron;
• Andriol;
• Androblok;
• Androgel;
• Androkur;
• Androkur Depot;
• Balutar;
• Bellune 35;
• Bicalutamide;
• Bicutuler;
• Bicane;
• Bikaprost;
• Bilumide;
• Grain;
• Casodex;
• Nebido;
• Nemestran;
• Omnadren 250;
• Penester;
• Proviron;
• Proscar;
• Prosteride;
• Testosterone propionate;
• Test for injection 10%;
• Urofin;
• Finast;
• Finasteride;
• Finpros;
• Flutakan;
• Flutamide;
• Flutaplex;
• Chloe;
• Cyproterone;
• Erica 35.

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