Azitrox - instructions for use, antibiotic analogs, testimonials and release forms (capsules or tablets 250 mg and 500 mg powder for the preparation of a suspension) drugs for the treatment of angina, bronchitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Azitrox. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of antibiotics Azitrox in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Azitrox in the presence of existing structural analogues.Use for the treatment of angina, bronchitis, pneumonia and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Azitrox - antibiotic group of macrolides, is a representative of azalides. Suppresses RNA-dependent protein synthesis of sensitive microorganisms.

It is active against gram-positive bacteria: Staphylococcus aureus (Staphylococcus aureus), Streptococcus spp. (streptococcus) (including Streptococcus pneumoniae, Streptococcus pyogenes (group A)); Gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila (Legionella); anaerobic bacteria: Bacteroides fragilis.

Azithromycin is also active against Chlamydia trachomatis (chlamydia), Mycoplasma pneumoniae (Mycoplasma), Mycoplasma hominis, Treponema pallidum.

It is also active against Toxoplasma gondii.

Composition

Azithromycin + excipients.

Pharmacokinetics

Quickly absorbed from the digestive tract. Eating lowers the absorption of azithromycin. Rapidly distributed in tissues and biological fluids. 35% of Azithromycin is metabolized in the liver by demethylation. More than 59% is excreted in bile in unchanged form, about 4.5% - with urine in unchanged form.

Indications

Infectious-inflammatory diseases caused by microorganisms susceptible to azithromycin:

• bronchitis;
• pneumonia;
• infection of the skin and soft tissues (face, furuncle, carbuncle);
• middle and purulent otitis media;
• sinusitis (sinusitis);
• pharyngitis;
• angina;
• tonsillitis;
• gonorrheal and non-nasal urethritis and / or cervicitis;
• chlamydia;
• mycoplasmosis;
• diseases of the stomach and duodenum, associated with Helicobacter pylori (as part of combination therapy);
• Lyme disease (borreliosis).

Forms of release

Capsules 250 mg and 500 mg (sometimes mistakenly called pills).

Powder for the preparation of a suspension for oral administration.

Instructions for use and dosage

Capsules

Azitrox is taken orally 1 time per day for 1 hour before or 2 hours after a meal.

Adults with infections of the upper and lower respiratory tract appoint 500 mg per day for 3 days (exchange dose - 1.5 g).

When skin and soft tissue infections are prescribed at a dose of 1 g per day for 1 reception on the first day, then - 500 mg per day every day from 2 to 5 days. The course dose is 3 g.

With uncomplicated urethritis and / or cervicitis, appoint only 1 g.

With complicated, long-term urethritis / cervicitis caused by Chlamydia trachomatis, 1 g 3 times at intervals of 7 days (taking the drug at 1-7-14 days of treatment). The course dose is 3 g.

In Lyme disease (borreliosis) for the treatment of stage 1 (erythema migrans), 1 g is prescribed on day 1 and 500 mg daily from day 2 to day 5.The course dose is 3 g.

With gastric ulcer and duodenal ulcer associated with Helicobacter pylori, appoint 1 g per day for 3 days as a combination of anti-Helicobacter therapy.

Children with a body weight of more than 45 kg with infections of the upper and lower respiratory tract, skin and soft tissues, scarlet fever, the drug is prescribed 500 mg per day (1 capsule) for 1 reception for 3 days.

For children older than 12 years, the drug (250 mg capsules) is prescribed at the rate of 10 mg / kg once a day for 3 days or on the first day - 10 mg / kg, then 4 days - 5-10 mg / kg per day in within 3 days. The course dose is 30 mg / kg.

In the treatment of erythema migrans in children, the dose of the drug (capsules 500 mg) is 1 g in day 1 and 500 mg daily from day 2 to day 5. The course dose is 3 g. Use Azitrox in the form of 250 mg capsules should be given at a dose of 20 mg / kg on the first day and 10 mg / kg on the 2nd to the 5th day.

Suspension

Established individually, taking into account the nosological form, the severity of the disease and the sensitivity of the pathogen.

Adults inside - 0.25-1 g once a day; children - 5-10 mg / kg once a day. Duration of treatment is 2-5 days.

Side effect

• diarrhea, constipation;
• nausea, vomiting;
• stomach ache;
• dyspepsia;
• flatulence;
• cholestatic jaundice;
• increased activity of hepatic transaminases;
• anorexia;
• gastritis;
• Candidomycosis of the oral mucosa;
• a feeling of palpitations;
• pain in the chest;
• dizziness;
• headache;
• drowsiness;
• headache (with medication otitis media);
• hyperkinesia;
• anxiety;
• neurosis;
• sleep disorders;
• vaginal candidiasis;
• nephritis;
• rash;
• photosensitization;
• itching;
• angioedema;
• hives;
• conjunctivitis;
• increased fatigue.

Contraindications

• liver failure;
• kidney failure;
• children with body weight less than 45 kg (for capsules 500 mg);
• children under 12 years (for capsules);
• increased sensitivity to antibiotics of macrolides.

Application in pregnancy and lactation

The use of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

Use in children

Azitrox capsules are contraindicated in children under 12 years of age.

The use of a suspension in children is possible according to the dosing regimen.

special instructions

Azitrox should not be taken with food.

In case of missing the next dose, the missed dose should be taken as soon as possible, and the subsequent dose should be taken at an interval of 24 hours.

It is necessary to observe a break of at least 2 h between taking Azitrox and antacid preparations.

After the withdrawal of treatment, hypersensitivity reactions in some patients may persist, which requires specific therapy under the supervision of a physician.

Drug Interactions

Antacids (aluminum and magnesium-containing), ethanol (alcohol) and food slow down and reduce the absorption of azithromycin.

Azithromycin does not bind to the isoenzymes of the cytochrome P450 system. Unlike most macrolides, at present no interaction of azithromycin with theophylline, terfenadine, carbamazepine, triazolam, Digoxin has been observed.

Macrolides (with the exception of azalides) slow down excretion and increase the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, and also drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine, phenytoin, oral hypoglycemic agents, xanthine derivatives, incl.theophylline), by inhibiting microsomal oxidation in hepatocytes, while no such interaction has been observed with the use of azalides.

With the simultaneous use of azithromycin with digoxin, an increase in the concentration of the latter is observed.

With the simultaneous administration of Warfarin and azithromycin (in usual doses), no changes in prothrombin time have been detected, but considering that the interaction of macrolides and warfarin may enhance the anticoagulant effect, patients need careful monitoring of prothrombin time.

With the simultaneous use of Azitrox with ergotamine and dihydroergotamine, their toxic effect (vasospasm, dysesthesia) is enhanced.

With the simultaneous use of azithromycin with triazolam, clearance decreases and the pharmacological action of triazolam is enhanced.

Lincosamines reduce the effectiveness of azithromycin.

Tetracycline and chloramphenicol increase the effectiveness of azithromycin.

Pharmaceutical incompatibility

Azithromycin is pharmaceutically incompatible with heparin.

Analogs of the drug Azitrox

Structural analogs for the active substance:

• Azivok;
• Azimycin;
• Azitral;
• Azithromycin;
• Azithromycin Forte;
• Azithromycin dihydrate;
• AsitRus;
• AzitRus forte;
• Azicid;
• Zetamax retard;
• ZI Factor;
• Zitnob;
• Zitrolide;
• Zitrolid forte;
• Zitrocin;
• Sumazid;
• Sumaclide;
• Sumamed;
• Sumamed forte;
• Sumamecin;
• Sumamecin forte;
• Sumamox;
• Sumatrolide solute;
• Sumatrolide Solidshn Tablets;
• Tremak Sanovel;
• Hemomycin;
• Ecomed.

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